Abstract:
:The allele frequency net database (http://www.allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its significance in transplantation, disease association studies and diversity in populations led to the development of this electronic resource. At present, the system contains data from 1133 populations in 608,813 individuals on the frequency of genes from different polymorphic regions such as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility complex Class I chain-related genes and a number of cytokine gene polymorphisms. The project was designed to create a central source for the storage of frequency data and provide individuals with a set of bioinformatics tools to analyze the occurrence of these variants in worldwide populations. The resource has been used in a wide variety of contexts, including clinical applications (histocompatibility, immunology, epidemiology and pharmacogenetics) and population genetics. Demographic information, frequency data and searching tools can be freely accessed through the website.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Gonzalez-Galarza FF,Christmas S,Middleton D,Jones ARdoi
10.1093/nar/gkq1128subject
Has Abstractpub_date
2011-01-01 00:00:00pages
D913-9issue
Database issueeissn
0305-1048issn
1362-4962pii
gkq1128journal_volume
39pub_type
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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更新日期:2007-01-01 00:00:00
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更新日期:2003-04-01 00:00:00
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journal_title:Nucleic acids research
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