Abstract:
:While sunlight is important for life, ultraviolet radiation (UVR) can have harmful and mutagenic effects. This duality is particularly relevant to human skin, in which UVR both participates in evolutionarily important photochemical reactions yet may act as a potential carcinogen. UVR can upregulate production of melanin, the "tanning response" that serves a photoprotective function. This genetic program is centrally tuned by the transcription factor MITF, a master regulator of melanogenesis and melanocyte function. In this review, we discuss the myriad consequences of UV exposure for skin homeostasis, highlighting the diverse pathways activated by this ultraviolet radiation.
journal_name
Pigment Cell Melanoma Resjournal_title
Pigment cell & melanoma researchauthors
Liu JJ,Fisher DEdoi
10.1111/j.1755-148X.2010.00775.xsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
741-5issue
6eissn
1755-1471issn
1755-148Xpii
PCR775journal_volume
23pub_type
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