Abstract:
:It is uncertain whether interferon levels in the interstitial fluid of tumors are equivalent to interferon plasma levels and we have investigated this problem in human pulmonary tumors by infusing human recombinant interferon alpha A and natural interferon Beta for about three hours before surgery. By determining the hematocrit and hemoglobin content it was possible to calculate interferon values (International Units/g wet tissue) present in the interstitial fluid of tumor and lung samples, simultaneously. In 14 patients (epidermoids, n = 9 and adenocarcinomas, n = 5) interferon levels in tumor and "normal" lung expressed as percentages of interferon plasma levels were: 9.5 +/- 3.9 and 29.8 +/- 6.9 for recombinant interferon alpha A and 3.1 +/- 0.4 and 10.1 +/- 2.4 for natural interferon Beta, respectively. Differences for both interferons are statistically significant (p less than 0.05). To our knowledge these are the first data indicating that interferon levels in pulmonary tumor interstitial fluid are markedly lower than those in normal lung although they do not clarify the main factor responsible for the decrease, they explain at least in part the negligible therapeutic activity of interferons in these tumors and emphasize the need for new approaches for improving the therapeutic index of interferons.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Bocci V,Carraro F,Naldini A,Borrelli E,Biagi G,Gotti G,Giomarelli PPsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
153-6issue
4eissn
0393-974Xissn
1724-6083journal_volume
4pub_type
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
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abstract::This study highlights the close link between upper and lower airways and the relevance of bronchodilation test in patients presenting with moderate-severe persistent allergic rhinitis and mild persistent asthma. ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract::Pirfenidone is an antifibrotic agent for patients with pulmonary fibrosis, but this drug has adverse gastrointestinal (GI) effects. The first aim of this study was to assess GI symptoms due to pirfenidone by using a new questionnaire for reflux symptoms and dismotility symptoms. Whether adding herbal medicine of rikku...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,随机对照试验
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abstract::Much evidence suggests a cross-talking between nerve fibers and the immunity system. The immunomodulation by substance P includes cell activation and proliferation of human cells, with cytokine and chemokine generation and release. Substance P was first isolated by Leeman et al. as an undecapeptide with important neur...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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abstract::Retinoid X Receptors (RXRs) consist of a family of nuclear receptors that target and regulate multiple signalling pathways. The early evolutionary emergence of RXRs in comparison to other nuclear receptors may have allowed for the development of unique properties as transcriptional regulators. Indeed, the complexity o...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::Various hematopoietic malignant disorders have been shown to bear chromosome abnormalities of the 11q23 band, which can be rearranged with many different chromosomal regions in a wide variety of different leukemia subtypes. Several laboratories have identified a trithorax-related gene that is involved in most of the 1...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:1998-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract::The use of minimally invasive surgical techniques undoubtedly represents a huge advantage for both the clinician and the patient. This case report shows the possibility of making an implant-prosthetic rehabilitation in an upper jaw in a patient who presented dental elements 1.3 and 2.3 in bone inclusion. The use of co...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,信件
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更新日期:2015-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:10.23812/20-558-L
更新日期:2020-11-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::We report the case of a young girl (17-year-old) wounded by an accidental gunshot. The bullet entered through the skin midline over the navel area, passed through the stomach perforating the vena cava and, by breaking the right pedicle of L4, moved inside the vertebral canal (bridging the cauda equina) stopping just i...
journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2016-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
abstract::NeuroAIDS is one of the main complications of chronic HIV-infection. The Central Nervous System is an immunologic sanctuary for HIV and allows the persistence of the virus despite an efficient antiretroviral therapy. HIV-1 could promote the neurodegeneration through the induction of inflammation by the release of neur...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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