Abstract:
:Gelatin microspheres are well-known for their capacity to release growth factors in a controlled manner, but gelatin microspheres do not calcify in the absence of so-called bioactive substances that induce deposition of calcium phosphate (CaP) bone mineral. This study has investigated if CaP nanocrystals can be incorporated into gelatin microspheres to render these inert microspheres bioactive without compromising the drug releasing properties of gelatin microspheres. Incorporation of CaP nanocrystals into gelatin microspheres resulted into reduced biodegradation and drug release rates, whereas their calcifying capacity increased strongly compared to inert gelatin microspheres. The reduced drug release rate was correlated to the reduced degradation rate as caused by a physical cross-linking effect of CaP nanocrystals dispersed in the gelatin matrix. Consequently, these composite microspheres combine beneficial drug-releasing properties of organic gelatin with the calcifying capacity of a dispersed CaP phase.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Leeuwenburgh SC,Jo J,Wang H,Yamamoto M,Jansen JA,Tabata Ydoi
10.1021/bm1006344subject
Has Abstractpub_date
2010-10-11 00:00:00pages
2653-9issue
10eissn
1525-7797issn
1526-4602journal_volume
11pub_type
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