Abstract：
:The purpose of this study was to determine failure stresses and failure lengths of actively and passively stretched myofibrils. As expected, myofibrils failed at average sarcomere lengths (about 6-7μm) that vastly exceeded sarcomere lengths at which actin-myosin filament overlap ceases to exist (4μm) and thus actin-myosin-based cross-bridge forces are zero at failure. Surprisingly, however, actively stretched myofibrils had much greater failure stresses and failure energies than passively stretched myofibrils, thereby providing compelling evidence for strong force production independent of actin-myosin-based cross-bridge forces. Follow-up experiments in which titin was deleted and cross-bridge formation was inhibited at high and low calcium concentrations point to titin as the regulator of this force, independent of calcium. The results of this study point to a mechanism of force production that reduces stretch-induced muscle damage at extreme length and limits injury and force loss within physiologically relevant ranges of sarcomere and muscle lengths.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Leonard TR,Joumaa V,Herzog Wdoi
10.1016/j.jbiomech.2010.07.016subject
Has Abstractpub_date
2010-11-16 00:00:00pages
3063-6issue
15eissn
0021-9290issn
1873-2380pii
S0021-9290(10)00407-0journal_volume
43pub_type
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