Structural basis for high-affinity HER2 receptor binding by an engineered protein.

abstract：:Previously it was shown that yeast ADA2 protein is necessary for the full activity of some activation domains, such as VP16 and GCN4, in vivo and in vitro. These results suggest that ADA2 protein functions as a transcriptional coactivator or adaptor that bridges the interaction between certain acidic activation domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silverman N,Agapite J,Guarente L

更新日期：1994-11-22 00:00:00

abstract：:The major Hsp70 of the mitochondrial matrix (Ssc1 in yeast) is critically important for the translocation of proteins from the cytosol, across the mitochondrial inner membrane, and into the matrix. Tim44, a peripheral inner membrane protein with limited sequence similarity to the J domain of J-type cochaperones, tethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Silva PD,Schilke B,Walter W,Andrew A,Craig EA

更新日期：2003-11-25 00:00:00

abstract：:The crystal structure of the tetrameric DNA-binding domain of the single-stranded DNA binding protein from Escherichia coli was determined at a resolution of 2.9 A using multiwavelength anomalous dispersion. Each monomer in the tetramer is topologically similar to an oligomer-binding fold. Two monomers each contribute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raghunathan S,Ricard CS,Lohman TM,Waksman G

更新日期：1997-06-24 00:00:00

abstract：:Two pools of heparan sulfate proteoglycans have been selectively solubilized from rat liver plasma membranes by successive incubations with heparin and detergent. The two populations of proteoglycans have similar polyanionic properties as indicated by identical elution positions on ion-exchange chromatography on DEAE-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kjellén L,Pettersson I,Höök M

更新日期：1981-09-01 00:00:00

abstract：:The plant hormone abscisic acid (ABA) is produced in response to abiotic stresses and mediates stomatal closure in response to drought via recently identified ABA receptors (pyrabactin resistance/regulatory component of ABA receptor; PYR/RCAR). SLAC1 encodes a central guard cell S-type anion channel that mediates ABA-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandt B,Brodsky DE,Xue S,Negi J,Iba K,Kangasjärvi J,Ghassemian M,Stephan AB,Hu H,Schroeder JI

更新日期：2012-06-26 00:00:00

abstract：:Biotin carboxylase [biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming), EC 6.3.4.14] is the enzyme mediating the first step of the acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] reaction. We screened an Escherichia coli DNA library and a DNA fragment carrying the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo H,Shiratsuchi K,Yoshimoto T,Masuda T,Kitazono A,Tsuru D,Anai M,Sekiguchi M,Tanabe T

更新日期：1991-11-01 00:00:00

abstract：:Previous studies have established that humans and monkeys with damage to striate cortex are able to detect and localize bright targets within the resultant scotoma. Electrophysiological evidence in monkeys suggests that residual vision also might include sensitivity to direction of visual motion. We tested whether mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Rodman HR,Gross CG

更新日期：2001-01-02 00:00:00

abstract：:Protein homeostasis is critically important for cell viability. Key to this process is the refolding of misfolded or aggregated proteins by molecular chaperones or, alternatively, their degradation by proteases. In most prokaryotes and in chloroplasts and mitochondria, protein degradation is performed by the caseinoly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vahidi S,Ripstein ZA,Bonomi M,Yuwen T,Mabanglo MF,Juravsky JB,Rizzolo K,Velyvis A,Houry WA,Vendruscolo M,Rubinstein JL,Kay LE

更新日期：2018-07-10 00:00:00

abstract：:Cell surface receptor membrane localization is strongly dependent on protein-protein interactions often involving regulation by phosphorylation/dephosphorylation of the intracellular domains of membrane proteins. The present study was carried out to identify metabotropic glutamate receptor (mGluR) 3 regulatory binding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flajolet M,Rakhilin S,Wang H,Starkova N,Nuangchamnong N,Nairn AC,Greengard P

更新日期：2003-12-23 00:00:00

abstract：:Sulfate-assimilating organisms reduce inorganic sulfate for Cys biosynthesis. There are two leading hypotheses for the mechanism of sulfate reduction in higher plants. In one, adenosine 5'-phosphosulfate (APS) (5'-adenylysulfate) sulfotransferase carries out reductive transfer of sulfate from APS to reduced glutathion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Setya A,Murillo M,Leustek T

更新日期：1996-11-12 00:00:00

abstract：:Ring-shaped hexameric helicases and translocases support essential DNA-, RNA-, and protein-dependent transactions in all cells and many viruses. How such systems coordinate ATPase activity between multiple subunits to power conformational changes that drive the engagement and movement of client substrates is a fundame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomsen ND,Lawson MR,Witkowsky LB,Qu S,Berger JM

更新日期：2016-11-29 00:00:00

abstract：:The wetting of microstructured surfaces is studied both experimentally and theoretically. Even relatively simple surface topographies such as grooves with rectangular cross section exhibit a large variety of different wetting morphologies as observed by atomic force microscopy. This polymorphism arises from liquid wed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seemann R,Brinkmann M,Kramer EJ,Lange FF,Lipowsky R

更新日期：2005-02-08 00:00:00

abstract：:Regulation of irreversible cell lineage commitment depends on a delicate balance between positive and negative regulators, which comprise a sophisticated network of transcription factors. Receptor activator of NF-kappaB ligand (RANKL) stimulates the differentiation of bone-resorbing osteoclasts through the induction o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishikawa K,Nakashima T,Hayashi M,Fukunaga T,Kato S,Kodama T,Takahashi S,Calame K,Takayanagi H

更新日期：2010-02-16 00:00:00

abstract：:A recombinant vaccinia virus that directs the synthesis of bacteriophage T7 RNA polymerase provides the basis for the expression of genes that are regulated by T7 promoters in mammalian cells. The T7 transcripts, which account for as much as 30% of the total cytoplasmic RNA at 24 hr after infection, are largely uncapp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elroy-Stein O,Fuerst TR,Moss B

更新日期：1989-08-01 00:00:00

abstract：:Osedax is a recently discovered group of siboglinid annelids that consume bones on the seafloor and whose evolutionary origins have been linked with Cretaceous marine reptiles or to the post-Cretaceous rise of whales. Here we present whale bones from early Oligocene bathyal sediments exposed in Washington State, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiel S,Goedert JL,Kahl WA,Rouse GW

更新日期：2010-05-11 00:00:00

abstract：:The successful treatment of cancer by boron neutron-capture therapy (BNCT) requires the selective concentration of boron-10 within malignant tumors. The potential of liposomes to deliver boron-rich compounds to tumors has been assessed by the examination of the biodistribution of boron delivered by liposomes in tumor-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shelly K,Feakes DA,Hawthorne MF,Schmidt PG,Krisch TA,Bauer WF

更新日期：1992-10-01 00:00:00

abstract：:Fourier transform infrared (FTIR) spectroscopy provides a unique molecular fingerprint of tissue from endogenous sources of light absorption; however, specific molecular components of the overall FTIR signature of precancer have not been characterized. In attenuated total reflectance mode, infrared light penetrates on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang TD,Triadafilopoulos G,Crawford JM,Dixon LR,Bhandari T,Sahbaie P,Friedland S,Soetikno R,Contag CH

更新日期：2007-10-02 00:00:00

abstract：:Notwithstanding important advances in the context of single-variant pathogenicity identification, novel breakthroughs in discerning the origins of many rare diseases require methods able to identify more complex genetic models. We present here the Variant Combinations Pathogenicity Predictor (VarCoPP), a machine-learn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papadimitriou S,Gazzo A,Versbraegen N,Nachtegael C,Aerts J,Moreau Y,Van Dooren S,Nowé A,Smits G,Lenaerts T

更新日期：2019-06-11 00:00:00

abstract：:It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species. SOD recently has been shown to prevent calcineurin inactivation, initiating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JP,Palfrey HC,Bindokas VP,Ghadge GD,Ma L,Miller RJ,Roos RP

更新日期：1999-03-16 00:00:00

abstract：:Photochemical release (uncaging) of bioactive messengers with three-dimensional spatial resolution in light-scattering media would be greatly facilitated if the photolysis could be powered by pairs of IR photons rather than the customary single UV photons. The quadratic dependence on light intensity would confine the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuta T,Wang SS,Dantzker JL,Dore TM,Bybee WJ,Callaway EM,Denk W,Tsien RY

更新日期：1999-02-16 00:00:00

abstract：:The roots and stems of dicotyledonous plants thicken by the cell proliferation in the cambium. Cambial proliferation changes in response to environmental factors; however, the molecular mechanisms that regulate cambial activity are largely unknown. The quadruple Arabidopsis thaliana mutant atipt1;3;5;7, in which 4 gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumoto-Kitano M,Kusumoto T,Tarkowski P,Kinoshita-Tsujimura K,Václavíková K,Miyawaki K,Kakimoto T

更新日期：2008-12-16 00:00:00

abstract：:Huntington's disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and the important role o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dargaei Z,Bang JY,Mahadevan V,Khademullah CS,Bedard S,Parfitt GM,Kim JC,Woodin MA

更新日期：2018-02-13 00:00:00

abstract：:Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian syste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris CJ,Purvis TE,Hu K,Scheer FA

更新日期：2016-03-08 00:00:00

abstract：:Evidence suggests that cholinergic input to the hippocampus plays an important role in learning and memory and that degeneration of cholinergic terminals in the hippocampus may contribute to the memory loss associated with Alzheimer's disease. One of the more prominent effects of cholinergic agonists on hippocampal ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MJ,Rouse ST,Levey AI,Potter LT,Conn PJ

更新日期：1998-09-15 00:00:00

abstract：:For over 40 y the dominant theory of stomatal behavior has been that plants should open stomates until the carbon gained by an infinitesimal additional opening balances the additional water lost times a water price that is constant at least over short periods. This theory has persisted because of its remarkable succes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolf A,Anderegg WR,Pacala SW

更新日期：2016-11-15 00:00:00

abstract：:A central question in developmental biology has been the initiation of cell-specific gene expression and its temporal relationship to morphogenesis. We have coupled embryo microdissection with the exquisite sensitivity of the polymerase chain reaction to define the onset of cell-specific gene expression during pancrea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gittes GK,Rutter WJ

更新日期：1992-02-01 00:00:00

abstract：:Serum amyloid A (SAA) is an acute-phase plasma protein that functions in innate immunity and lipid homeostasis. SAA is a protein precursor of reactive AA amyloidosis, the major complication of chronic inflammation and one of the most common human systemic amyloid diseases worldwide. Most circulating SAA is protected f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaraman S,Gantz DL,Haupt C,Gursky O

更新日期：2017-08-08 00:00:00

abstract：:The origins and consequences of a regulatory T cell (Treg) disorder in systemic lupus erythematosus (SLE) are poorly understood. In the (NZBxNZW) F(1) mouse model of lupus, we found that CD4(+)Foxp3(+) Treg failed to maintain a competitive pool size in the peripheral lymphoid organs resulting in a progressive homeosta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Humrich JY,Morbach H,Undeutsch R,Enghard P,Rosenberger S,Weigert O,Kloke L,Heimann J,Gaber T,Brandenburg S,Scheffold A,Huehn J,Radbruch A,Burmester GR,Riemekasten G

更新日期：2010-01-05 00:00:00

abstract：:"Evolution behaves like a tinkerer" (François Jacob, Science, 1977). Software systems provide a singular opportunity to understand biological processes using concepts from network theory. The Debian GNU/Linux operating system allows us to explore the evolution of a complex network in a unique way. The modular design d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fortuna MA,Bonachela JA,Levin SA

更新日期：2011-12-13 00:00:00

abstract：:Cancers frequently arise as a result of an acquired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patterns of genetic aberrations. Thus, the presence and behaviors of distinct clonal populations in each patient's tumor may underlie multiple clinical phenotypes in cancers. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz C,Lenkiewicz E,Evers L,Holley T,Robeson A,Kiefer J,Demeure MJ,Hollingsworth MA,Shen M,Prunkard D,Rabinovitch PS,Zellweger T,Mousses S,Trent JM,Carpten JD,Bubendorf L,Von Hoff D,Barrett MT

更新日期：2011-07-19 00:00:00