Study on the composition-structure relationship of lipophorins.

abstract：:Boiled coffee contains an unidentified lipid that raises serum cholesterol. We studied the effects of the ingestion of coffee oil fractions of increasing purity in volunteers in order to identify the cholesterol-raising factor. In 15 volunteers who ingested 0.75 g/d of a non-triglyceride-fraction from coffee oil for 4...

journal_title：Journal of lipid research

authors： Weusten-Van der Wouw MP,Katan MB,Viani R,Huggett AC,Liardon R,Liardon R,Lund-Larsen PG,Thelle DS,Ahola I,Aro A

更新日期：1994-04-01 00:00:00

abstract：:We investigated the formation and pharmacology of prostaglandin E(3) (PGE(3)) derived from fish oil eicosapentaenoic acid (EPA) in human lung cancer A549 cells. Exposure of A549 cells to EPA resulted in the rapid formation and export of PGE(3.) The extracellular ratio of PGE(3) to PGE(2) increased from 0.08 in control...

journal_title：Journal of lipid research

authors： Yang P,Chan D,Felix E,Cartwright C,Menter DG,Madden T,Klein RD,Fischer SM,Newman RA

更新日期：2004-06-01 00:00:00

abstract：:Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe(2+), and is further stimulated by the presence of pyrophosphate. Thiamine pyrophosphate contained sufficient iron as an impurity to provide strong enhancement of the reaction in...

journal_title：Journal of lipid research

authors： Roberts AB,DeLuca HF

更新日期：1968-07-01 00:00:00

abstract：:This report describes the chemical synthesis of isoursocholic acid (3 beta, 7 beta, 12 alpha-trihydroxy-5 beta-cholanoic acid) from its corresponding 3 alpha-analog. The method consists of refluxing a mixture of ursocholic acid, triphenylphosphine, and diethyl azodicarboxylate in benzene solution with an acid such as ...

journal_title：Journal of lipid research

authors： Dayal B,Salen G

更新日期：1991-08-01 00:00:00

abstract：:To determine the acute effects of insulin on lipoprotein metabolism, we have followed the plasma lipoprotein lipid and apolipoprotein levels during insulin therapy for the first 24 hr in 13 patients with diabetic ketoacidosis. Corrections were made for plasma volume changes during treatment. Before insulin treatment, ...

journal_title：Journal of lipid research

authors： Weidman SW,Ragland JB,Fisher JN Jr,Kitabchi AE,Sabesin SM

更新日期：1982-01-01 00:00:00

abstract：:Fluorescence energy transfer from dehydroergosterol (DHE) to dansylated lecithin (DL) was used to characterize lecithin-cholesterol vesicles in the presence of the bile salt, sodium taurocholate. At lipid concentrations approximating physiological levels, exposure of fluorescently labeled vesicles to the bile salt led...

journal_title：Journal of lipid research

authors： Wrenn SP,Gudheti M,Veleva AN,Kaler EW,Lee SP

更新日期：2001-06-01 00:00:00

abstract：:High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induc...

journal_title：Journal of lipid research

authors： Irani S,Iqbal J,Antoni WJ,Ijaz L,Hussain MM

更新日期：2018-01-01 00:00:00

abstract：:The total nitrogen and L-hydroxyproline concentrations of two intra-abdominal and two subcutaneous sites of adipose tissue were measured in male and female Wistar rats. At 100 g body weight the nitrogen concentration of intra-abdominal adipose tissue was slightly lower than that of subcutaneous adipose tissue. As age ...

journal_title：Journal of lipid research

authors： Curtis-Prior PB,Hanley T,Trethewey J,Stewart GA

更新日期：1970-07-01 00:00:00

abstract：:In studies of cebus monkey plasma lipoproteins, we have used an ultracentrifugally generated density gradient to isolate two distinct species of low density lipoproteins (LDL). Compositional analyses revealed that each of the ultracentrifugally isolated fractions was enriched in cholesteryl esters and contained a sing...

journal_title：Journal of lipid research

authors： Puppione DL,Nicolosi RJ,Kowala MC,Schumaker VN

更新日期：1989-05-01 00:00:00

abstract：:Ac-hE18A-NH2 is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141-150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH2 reduces plasma cholesterol in animal models and exhibits anti-inflammatory properties...

journal_title：Journal of lipid research

authors： Anantharamaiah GM,Garber DW,Goldberg D,Morrel E,Datta G,Palgunachari MN,Register TC,Appt SE,White CR

更新日期：2018-11-01 00:00:00

abstract：:We used [2-13C1]glycerol to characterize very low density lipoprotein (VLDL)-triglyceride kinetics and intrahepatic glycerol metabolism in normal men (n = 4) after alcohol (EtOH) ingestion. [2-13C1]glycerol was infused before and after the consumption of 48 g EtOH or a placebo. Three additional subjects also received ...

journal_title：Journal of lipid research

authors： Siler SQ,Neese RA,Parks EJ,Hellerstein MK

更新日期：1998-12-01 00:00:00

abstract：:Serum amyloid P (SAP) is a common component of human amyloid deposits and has been identified in atherosclerotic lesions. We investigated the extent of the colocalization of SAP with apolipoprotein A-I (apoA-I), apoB, apoC-II, and apoE in human coronary arteries and explored potential roles for SAP in these regions, s...

journal_title：Journal of lipid research

authors： Stewart CR,Haw A 3rd,Lopez R,McDonald TO,Callaghan JM,McConville MJ,Moore KJ,Howlett GJ,O'Brien KD

更新日期：2007-10-01 00:00:00

abstract：:Inflammation has been proposed to impair HDL function and reverse cholesterol transport (RCT). We investigated the effects of inflammation mediated by zymosan, a yeast glucan, on multiple steps along the RCT pathway in vivo and ex vivo. Acute inflammation with 70 mg/kg zymosan impaired RCT to plasma, liver, and feces ...

journal_title：Journal of lipid research

authors： Malik P,Berisha SZ,Santore J,Agatisa-Boyle C,Brubaker G,Smith JD

更新日期：2011-05-01 00:00:00

abstract：:PAF-dependent transacetylase (TA) modifies the functions of platelet-activating factor (PAF), a potent inflammatory lipid, either by transferring the acetyl group from PAF to lysophospholipids (TAL activity), or to sphingosine (TAS activity) or by hydrolyzing PAF (acetylhydrolase activity). In stimulated endothelial c...

journal_title：Journal of lipid research

authors： Balestrieri ML,Castaldo D,Balestrieri C,Quagliuolo L,Giovane A,Servillo L

更新日期：2003-02-01 00:00:00

abstract：:Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-...

journal_title：Journal of lipid research

authors： Al-Hilal M,Alsaleh A,Maniou Z,Lewis FJ,Hall WL,Sanders TA,O'Dell SD,MARINA study team.

更新日期：2013-02-01 00:00:00

abstract：:HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the effects of pharmac...

journal_title：Journal of lipid research

authors： Ma A,Wang J,Yang L,An Y,Zhu H

更新日期：2017-08-01 00:00:00

abstract：:Percent cholesterol absorption was measured in 94 normal subjects aged 17- 80 years while consuming diets generally low in cholesterol (mean intake = 226 +/- 126 mg/day). A new dual stable isotope method was used where a cholesterol tracer containing 6 extra mass units was given intravenously and another tracer with 5...

journal_title：Journal of lipid research

authors： Bosner MS,Lange LG,Stenson WF,Ostlund RE Jr

更新日期：1999-02-01 00:00:00

abstract：:Ceramides play an essential role in modulating immune signaling pathways and proinflammatory cytokine production in response to infectious pathogens, stress stimuli, or chemotherapeutic drugs. In this study, we demonstrated that Aggregatibacter actinomycetemcomitans, the pathogen for aggressive periodontitis, induced ...

journal_title：Journal of lipid research

authors： Yu H,Valerio M,Bielawski J

更新日期：2013-01-01 00:00:00

abstract：:Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues. The enzyme has been assayed by complicated methods using radiolabel...

journal_title：Journal of lipid research

authors： Ota Y,Eto TA,Tanaka S,Sueta H,Shiotsuki H,Maeda Y,Une M,Chijiiwa K

更新日期：2003-12-01 00:00:00

abstract：:Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its dual function: cyclization of 2,3-monoepoxysqualene to lanosterol and 2,3;22,23-diepoxysqualene to oxylanosterol. Further determination of the significance of this enzyme for the intracellu...

journal_title：Journal of lipid research

authors： Mark M,Muller P,Maier R,Eisele B

更新日期：1996-01-01 00:00:00

abstract：:Cholesterol 7alpha-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is highly regulated. Our cyp7A1 gene knockout mouse colony, as young a...

journal_title：Journal of lipid research

authors： Erickson SK,Lear SR,Deane S,Dubrac S,Huling SL,Nguyen L,Bollineni JS,Shefer S,Hyogo H,Cohen DE,Shneider B,Sehayek E,Ananthanarayanan M,Balasubramaniyan N,Suchy FJ,Batta AK,Salen G

更新日期：2003-05-01 00:00:00

abstract：:Phytanoyl-CoA hydroxylase (PhyH) catalyzes the conversion of phytanoyl-CoA to 2-hydroxyphytanoyl-CoA, which is the first step in the phytanic acid alpha-oxidation pathway. Recently, several studies have shown that in humans, phytanic acid alpha-oxidation is localized in peroxisomes. In rat, however, the alpha-oxidatio...

journal_title：Journal of lipid research

authors： Jansen GA,Ofman R,Denis S,Ferdinandusse S,Hogenhout EM,Jakobs C,Wanders RJ

更新日期：1999-12-01 00:00:00

abstract：:Chiral phase high performance liquid chromatographic resolution of sn-1,2(2,3)- and X-1,3-diacylglycerols generated by partial Grignard degradation from natural triacylglycerols was carried out using a chiral column (25 cm x 4.6 mm i.d.) containing (R)-(+)-1-(1-napthyl)ethylamine polymer chemically bonded to 300A wide...

journal_title：Journal of lipid research

authors： Itabashi Y,Kukis A,Marai L,Takagi T

更新日期：1990-09-01 00:00:00

abstract：:In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI...

journal_title：Journal of lipid research

authors： Muñiz M,Riezman H

更新日期：2016-03-01 00:00:00

abstract：:Adiponectin, an adipocyte-derived protein, has anti-atherogenic and anti-diabetic effects, but how it confers the anti-atherogenic effects is not well understood. To study the anti-atherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low-density lipoprotein (LDL) to attenuate LDL's ...

journal_title：Journal of lipid research

authors： Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

更新日期：2020-11-03 00:00:00

abstract：:Activation of cultured hepatic stellate cells correlated with an enhanced expression of proteins involved in uptake and storage of fatty acids (FA translocase CD36, Acyl-CoA synthetase 2) and retinol (cellular retinol binding protein type I, CRBP-I; lecithin:retinol acyltransferases, LRAT). The increased expression of...

journal_title：Journal of lipid research

authors： Hellemans K,Rombouts K,Quartier E,Dittié AS,Knorr A,Michalik L,Rogiers V,Schuit F,Wahli W,Geerts A

更新日期：2003-02-01 00:00:00

abstract：:A reproducible cell culture system is described that allows the study of adipose conversion in fibroblast-like cells isolated by collagenase digestion of epididymal and perirenal adipose tissue from male rats weighing 70-200 g. Adipose conversion as measured by lipid accumulation and increase in glycerophosphate dehyd...

journal_title：Journal of lipid research

authors： Wiederer O,Löffler G

更新日期：1987-06-01 00:00:00

abstract：:Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentrations of ∼10 mol%; diminished concentrations, along with altered or miss...

journal_title：Journal of lipid research

authors： Opálka L,Kováčik A,Pullmannová P,Maixner J,Vávrová K

更新日期：2020-02-01 00:00:00

abstract：:Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J mice through enhanced cholesterol conversion to b...

journal_title：Journal of lipid research

authors： Lee JM,Ong JR,Vergnes L,de Aguiar Vallim TQ,Nolan J,Cantor RM,Walters JRF,Reue K

更新日期：2018-03-01 00:00:00

abstract：:The effect of 26-hydroxycholesterol and other intermediates in bile acid synthesis on HMG-CoA reductase activity was studied in Chinese hamster ovary (CHO) cell culture. Incubation of CHO cells for 5 hr in 0.25 microM 26-hydroxycholesterol caused a 40% inhibition of HMG-CoA reductase activity. All other intermediates ...

journal_title：Journal of lipid research

authors： Esterman AL,Baum H,Javitt NB,Darlington GJ

更新日期：1983-10-01 00:00:00