Incidental findings are frequent in young healthy individuals undergoing magnetic resonance imaging in brain research imaging studies: a prospective single-center study.

Abstract:

OBJECTIVE:There is an ongoing debate about how to handle incidental findings (IF) detected in healthy individuals who participate in research-driven magnetic resonance imaging (MRI) studies. There are currently no established guidelines regarding their management. METHODS:We prospectively assessed the frequency of IF in 206 young healthy volunteers who additionally underwent structural MRIs of the whole brain as part of a scientific MRI protocol. RESULTS:Assessment of the structural MRI by 2 board-certified neuroradiologists revealed IF in 19% of the subjects (n = 39). In approximately half of these subjects (n = 21), these findings were of potential clinical relevance (eg, arteriovenous malformations, cavernomas, pituitary abnormalities) and required further diagnostic investigations. None of these potentially relevant IF prompted immediate active medical treatment. CONCLUSIONS:Incidental findings are very frequent in young healthy volunteers. Because many of the IF require further diagnostic workup, standardized procedures for MRI and the handling of these images are mandatory to ensure competent clinical management.

journal_name

J Comput Assist Tomogr

authors

Hartwigsen G,Siebner HR,Deuschl G,Jansen O,Ulmer S

doi

10.1097/RCT.0b013e3181d9c2bb

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

596-600

issue

4

eissn

0363-8715

issn

1532-3145

pii

00004728-201007000-00018

journal_volume

34

pub_type

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