Buckley-James boosting for survival analysis with high-dimensional biomarker data.

Abstract:

:There has been increasing interest in predicting patients' survival after therapy by investigating gene expression microarray data. In the regression and classification models with high-dimensional genomic data, boosting has been successfully applied to build accurate predictive models and conduct variable selection simultaneously. We propose the Buckley-James boosting for the semiparametric accelerated failure time models with right censored survival data, which can be used to predict survival of future patients using the high-dimensional genomic data. In the spirit of adaptive LASSO, twin boosting is also incorporated to fit more sparse models. The proposed methods have a unified approach to fit linear models, non-linear effects models with possible interactions. The methods can perform variable selection and parameter estimation simultaneously. The proposed methods are evaluated by simulations and applied to a recent microarray gene expression data set for patients with diffuse large B-cell lymphoma under the current gold standard therapy.

authors

Wang Z,Wang CY

doi

10.2202/1544-6115.1550

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

Article24

eissn

2194-6302

issn

1544-6115

journal_volume

9

pub_type

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