Abstract:
:We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Karlberg T,Markova N,Johansson I,Hammarström M,Schütz P,Weigelt J,Schüler Hdoi
10.1021/jm100249wsubject
Has Abstractpub_date
2010-07-22 00:00:00pages
5352-5issue
14eissn
0022-2623issn
1520-4804journal_volume
53pub_type
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