Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.

Abstract:

:We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.

journal_name

J Med Chem

authors

Karlberg T,Markova N,Johansson I,Hammarström M,Schütz P,Weigelt J,Schüler H

doi

10.1021/jm100249w

subject

Has Abstract

pub_date

2010-07-22 00:00:00

pages

5352-5

issue

14

eissn

0022-2623

issn

1520-4804

journal_volume

53

pub_type

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