Mitochondrial haplogroups associated with elite Japanese athlete status.

Abstract:

PURPOSE:It has been hypothesised that certain mitochondrial haplogroups, which are defined by the presence of a characteristic cluster of tightly linked mitochondrial DNA polymorphisms, would be associated with elite Japanese athlete status. To examine this hypothesis, the frequencies of mitochondrial haplogroups found in elite Japanese athletes were compared with those in the general Japanese population. METHODS:Subjects comprised 139 Olympic athletes (79 endurance/middle-power athletes (EMA), 60 sprint/power athletes (SPA)) and 672 controls (CON). Two mitochondrial DNA fragments containing the hypervariable sequence I (m16024-m16383) of the major non-coding region and the polymorphic site at m.5178C>A within the NADH dehydrogenase subunit 2 gene were sequenced, and subjects were classified into 12 major mitochondrial haplogroups (ie, F, B, A, N9a, N9b, M7a, M7b, M*, G2, G1, D5 or D4). The mitochondrial haplogroup frequency differences among EMA, SPA and CON were then examined. RESULTS:EMA showed an excess of haplogroup G1 (OR 2.52, 95% CI 1.05 to 6.02, p=0.032), with 8.9% compared with 3.7% in CON, whereas SPA displayed a greater proportion of haplogroup F (OR 2.79, 95% CI 1.28 to 6.07, p=0.007), with 15.0% compared with 6.0% in CON. CONCLUSIONS:The results suggest that mitochondrial haplogroups G1 and F are associated with elite EMA and SPA status in Japanese athletes, respectively.

journal_name

Br J Sports Med

authors

Mikami E,Fuku N,Takahashi H,Ohiwa N,Scott RA,Pitsiladis YP,Higuchi M,Kawahara T,Tanaka M

doi

10.1136/bjsm.2010.072371

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1179-83

issue

15

eissn

0306-3674

issn

1473-0480

pii

bjsm.2010.072371

journal_volume

45

pub_type

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