Abstract：
:The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Makihira S,Shuto T,Nikawa H,Okamoto K,Mine Y,Takamoto Y,Ohara M,Tsuji Kdoi
10.3390/ijms11041458subject
Has Abstractpub_date
2010-04-02 00:00:00pages
1458-70issue
4issn
1422-0067journal_volume
11pub_type
杂志文章abstract：:Late blight caused by Phytophthora infestans (Montagne, Bary) is a devastating disease of tomato worldwide. There are three known major genes, Ph-1, Ph-2, and Ph-3, conferring resistance to late blight. In addition to these three genes, it is also believed that there are additional factors or quantitative trait loci (...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071589
更新日期：2017-07-22 00:00:00
abstract：:Obesity results from an imbalance between energy intake and energy expenditure, in which excess fat is stored as triglycerides (TGs) in white adipocytes. Recent studies have explored the anti-obesity effects of certain edible phytochemicals, which suppress TG accumulation and stimulate a brown adipocyte-like phenotype...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062153
更新日期：2020-03-20 00:00:00
abstract：:Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery set (13 patients) or replicat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020295
更新日期：2017-01-29 00:00:00
abstract：:In Arabidopsis basal hypocotyls of dark-grown seedlings, xylary cells may form from the pericycle as an alternative to adventitious roots. Several hormones may induce xylogenesis, as Jasmonic acid (JA), as well as indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) auxins, which also affect xylary identity. Stu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184469
更新日期：2019-09-10 00:00:00
abstract：:tRNA and some other non-coding RNA genes are transcribed by RNA polymerase III (pol III), due to the presence of intragenic promoter, consisting of boxes A and B spaced by 30-40 bp. Such pol III promoters, called type 2, are also intrinsic to Short Interspersed Elements (SINEs). The contribution of 5'-flanking sequenc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103706
更新日期：2020-05-25 00:00:00
abstract：:Overexpression of a constitutively active truncated form of OsCDPK1 (OEtr) in rice produced smaller seeds, but a double-stranded RNA gene-silenced form of OsCDPK1 (Ri) yielded larger seeds, suggesting that OsCDPK1 plays a functional role in rice seed development. In the study presented here, we propose a model in whic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103247
更新日期：2018-10-19 00:00:00
abstract：:Microalgae are unicellular photosynthetic organisms considered as potential alternative sources for biomass, biofuels or high value products. However, limited biomass productivity is commonly experienced in their cultivating system despite their high potential. One of the reasons for this limitation is the high therma...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010155
更新日期：2018-01-05 00:00:00
abstract：:Recent studies have shown that plumbagin has anti-inflammatory, anti-allergic, antibacterial, and anti-cancer activities; however, it has not yet been shown whether plumbagin suppresses alpha-melanocyte stimulating hormone (α-MSH)-induced melanin synthesis to prevent hyperpigmentation. In this study, we demonstrated t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020320
更新日期：2017-02-03 00:00:00
abstract：:Platelet extracellular vesicles (PEVs) are potential new biomarkers of platelet activation which may allow us to predict and/or diagnose developing coronary thrombosis before myocardial necrosis occurs. The P2Y1 and P2Y12 receptors play a key role in platelet activation and aggregation. Whereas the P2Y1 antagonists ar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176065
更新日期：2020-08-23 00:00:00
abstract：:Ataxia is a common clinical feature in inherited metabolic disorders. There are more than 150 inherited metabolic disorders in patients presenting with ataxia in addition to global developmental delay, encephalopathy episodes, a history of developmental regression, coarse facial features, seizures, and other types of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155519
更新日期：2020-08-01 00:00:00
abstract：:Leaf senescence is the last period of leaf growth and a dynamic procedure associated with its death. The adaptability of the plants to changing environments occurs thanks to leaf senescence. Hence, transcriptional profiling is important to figure out the exact mechanisms of inducing leaf senescence in a particular cro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071708
更新日期：2019-04-05 00:00:00
abstract：:Among the four immunoglobulin G (IgG) subclasses, IgG4 is the least represented in serum of a healthy human and it is considered an "odd" antibody. The IgG4 antibody has unique structural features that affect its biological function. These include the ability to undergo antigen-binding fragment (Fab)-arm exchange, to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145017
更新日期：2020-07-16 00:00:00
abstract：:Soluble receptors are widely understood to be freestanding moieties formed via cleavage from their membrane-bound counterparts. They have unique structures, are found among various receptor families, and have intriguing mechanisms of generation and release. Soluble receptors' ability to exhibit pleiotropic action by r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22031108
更新日期：2021-01-23 00:00:00
abstract：:Quantification of gene expression is crucial to connect genome sequences with phenotypic and physiological data. RNA-Sequencing (RNA-Seq) has taken a prominent role in the study of transcriptomic reactions of plants to various environmental and genetic perturbations. However, comparative tests of different tools for R...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051720
更新日期：2020-03-03 00:00:00
abstract：:Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melatonin are known as kynuramines. One of the best-known kynuramines is N¹-acetyl-N¹-formyl-5-methoxykynuramine (AFMK). Melatonin has attracted scientific attention as a potent antioxidant and protector of tissue against oxi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18051014
更新日期：2017-05-08 00:00:00
abstract：:Low temperature stress has a severe impact on the distribution, physiology, and survival of plants in their natural habitats. While numerous studies have focused on the physiological and molecular adjustments to low temperatures, this study provides evidence that cold induced physiological responses coincide with dist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228753
更新日期：2020-11-19 00:00:00
abstract：:Variegated plants are valuable materials for investigating leaf color regulated mechanisms. To unveil the role of posttranslational modification in the variegated phenotype, we conducted global quantitative phosphoproteomic analysis on different leaf color sectors of Maiyuanjinqiu and the corresponding of Catalpa farg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20081895
更新日期：2019-04-17 00:00:00
abstract：:Plant NADPH oxidases, formerly known as respiratory burst oxidase homologues (RBOHs), are plasma membrane enzymes dedicated to reactive oxygen species (ROS) production. These oxidases are implicated in a wide variety of processes, ranging from tissue and organ growth and development to signaling pathways in response t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17050680
更新日期：2016-05-18 00:00:00
abstract：:Ultraviolet (UV) radiation induces skin photoaging, which is associated with the elevation of matrix metalloproteinases (MMPs) and the impairment of collagen. The Euphrasia species play a well-known role in the treatment of certain eye disorders through their anti-oxidative and anti-inflammatory activities. However, t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113327
更新日期：2018-10-25 00:00:00
abstract：:The aim of the study was to investigate the effect of using direct electric current (DC) of 0, 200, and 400 mA for five minutes on the physiochemical properties, cytotoxicity, antibacterial, and antioxidant activity of sodium alginate hydrosols with different sodium chloride concentrations. The pH, oxidation-reduction...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030678
更新日期：2017-03-22 00:00:00
abstract：:Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from African clawed fogs Xenopus laevis) has antimicrobial activity against gram-positive and gram-negative bacteria. The present study was conducted ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103041
更新日期：2018-10-05 00:00:00
abstract：:Brassica campestris L., a hyperaccumulator of cadmium (Cd), is considered a candidate plant for efficient phytoremediation. The hairy roots of Brassica campestris L are chosen here as a model plant system to investigate the response mechanism of Brassica campestris L. to Cd stress. High-throughput sequencing technolog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010180
更新日期：2019-12-26 00:00:00
abstract：:Maternal overweight in pregnancy alters the metabolic environment and generates chronic low-grade inflammation. This affects fetal development and programs the offspring's health for developing cardiovascular and metabolic disease later in life. MME (membrane-metalloendopeptidase, neprilysin) cleaves various peptides ...
journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
doi：10.3390/ijms21030834
更新日期：2020-01-28 00:00:00
abstract：:Interleukin-1β (IL-1β) is a prominent pro-inflammatory cytokine that is implicated in a variety of autoimmune diseases and plays an important role in host defense against infections. IL-1β activity increases with its increasing binding capacity to IL-1 receptors (IL-1Rs). Thus, numerous studies have tar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071835
更新日期：2018-06-22 00:00:00
abstract：:Recent data show that cardiac hypertrophy contributes substantially to the overall heart failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy. Recent studies have reported that isosteviol inhibits myocardial ischemia-reperfusion injury in guinea pigs and H9c2 cells. This work investigat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020682
更新日期：2020-01-20 00:00:00
abstract：:Salidroside (Sal) is an active ingredient that is isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect. However, the role of Sal on renal fibrosis has not yet been elucidated. Here, the purpose of the current study is to test the protective effects of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051103
更新日期：2019-03-04 00:00:00
abstract：:Parkinson's disease (PD) is a complex disorder underpinned by both environmental and genetic factors. The latter only began to be understood around two decades ago, but since then great inroads have rapidly been made into deconvoluting the genetic component of PD. In particular, recent large-scale projects such as gen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197332
更新日期：2020-10-04 00:00:00
abstract：:Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer's disease, Parkinson's disease, and other related diseases. Recent medical advances have shown that many precursors and proteins can ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21061978
更新日期：2020-03-13 00:00:00
abstract：:The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life. Limitations of therapeutics for severe TMJ diseases have led to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19020446
更新日期：2018-02-02 00:00:00
abstract：:Fertilization is a cell biological phenomenon of crucial importance for the birth of new life in a variety of multicellular and sexual reproduction species such as algae, animal and plants. Fertilization involves a sequence of events, in which the female gamete "egg" and the male gamete "spermatozoon (sperm)" develop,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16010114
更新日期：2014-12-23 00:00:00
