Role of retinoic receptors in lung carcinogenesis.

abstract：BACKGROUND:Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biological function in gallbladder cancer (GBC) remain largely unknown. METHODS:PHB and p-ERK protein ex...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cao Y,Liang H,Zhang F,Luan Z,Zhao S,Wang XA,Liu S,Bao R,Shu Y,Ma Q,Zhu J,Liu Y

更新日期：2016-04-16 00:00:00

abstract：:Arsenic trioxide has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukemia (APL) as well as solid tumors. Arsenic can act through a considerable number of different pathways including mitochondrial respiration and tubulin formation, affecting growth, blood flow, diffe...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang TT,Brown SL,Kim JH

更新日期：2004-06-01 00:00:00

abstract：:Escherichia coli cytosine deaminase (CD), which is a prokaryotic enzyme, converts nontoxic prodrug 5-fluorocytosine (5-FC) into the toxic chemotherapeutic agent 5-fluorouracil (5-FU). To investigate an enzyme/prodrug gene therapy for colorectal cancer, using adenoviral gene transfer of the E. coli CD gene associated w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Koyama F,Sawada H,Fujii H,Hirao T,Ueno M,Hamada H,Nakano H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Corrado G,Laquintana V,Loria R,Carosi M,de Salvo L,Sperduti I,Zampa A,Cicchillitti L,Piaggio G,Cutillo G,Falcioni R,Vizza E

更新日期：2018-07-06 00:00:00

abstract：:Gastric cancer (GC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators of metastasis because of their ability to act on multiple signaling pathways. In our study, we found that miR-144 ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu J,Xue H,Zhang J,Suo T,Xiang Y,Zhang W,Ma J,Cai D,Gu X

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels and cause effective anti-tumor effects in diverse human cancers. However, its cytotoxic effect and rel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yin Y,Sun M,Zhan X,Wu C,Geng P,Sun X,Wu Y,Zhang S,Qin J,Zhuang Z,Liu Y

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have bee...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Solivetti FM,Elia F,Latini A,Cota C,Cordiali-Fei P,Di Carlo A

更新日期：2011-04-13 00:00:00

abstract：BACKGROUND:Increasing evidence has indicated an important role for estrogen receptor beta 1 (ERβ1) in breast cancer. However, the role of ERβ1 in the metastasis of androgen receptor (AR)-positive triple-negative breast cancer (TNBC) and the underlying mechanisms are still unknown. METHODS:Stable ERβ1-expressing TNBC c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Song W,Tang L,Xu Y,Sun Q,Yang F,Guan X

更新日期：2017-06-05 00:00:00

abstract：BACKGROUND:Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are overexpressed in many types o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi Y,Sun L,Zhang R,Hu Y,Wu Y,Dong X,Dong D,Chen C,Geng Z,Li E,Fan Y

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remains elusive. METHODS:Apolipoprotein (ApoE) knock-out mice was used to analyze the intraperitoneal EC...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

更新日期：2018-02-20 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common tumour of the central nervous system in humans. Unfortunately its prognosis is poor and because of the lack of efficacious therapies, immunotherapy is a potential treatment. Transfer factors (TF) are low molecular weight dialysable products extracted from immune cells wh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pineda B,Estrada-Parra S,Pedraza-Medina B,Rodriguez-Ropon A,Pérez R,Arrieta O

更新日期：2005-12-01 00:00:00

abstract：:We evaluated the efficacy and toxicity profile of single-agent docetaxel administered in daily clinical practice at low-dose regimen in 37 pre-treated elderly patients with metastatic breast cancer previously exposed to chemotherapy. Docetaxel was employed by physician's preference according to a weekly (8 patients, 2...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Massacesi C,Marcucci F,Boccetti T,Battelli N,Pilone A,Rocchi MB,Bonsignori M

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Multi-drug resistance and predisposition to metastasize are major clinical problems in cancer treatment. Malignant primary brain tumor and pancreatic cancer are two well-known examples of malignant tumors resistant to conventional therapies where aberrant EGFR-mediated and NF-κB signal transduction pathways ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Guerra B,Fischer M,Schaefer S,Issinger OG

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Zhang Z,Zhang Y,Cao Y,Wei H,Wu Z

更新日期：2018-02-26 00:00:00

abstract：BACKGROUND:Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Po...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Criscuolo D,Morra F,Giannella R,Visconti R,Cerrato A,Celetti A

更新日期：2019-02-22 00:00:00

abstract：:Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guidelines, many questions are still open. Among them, it should be acknowledged that the treatment for stage IB d...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bonomi M,Pilotto S,Milella M,Massari F,Cingarlini S,Brunelli M,Chilosi M,Tortora G,Bria E

更新日期：2011-12-29 00:00:00

abstract：BACKGROUND:DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a significant role in maintaining DNA methylation status and regulating the expression of tumor suppressor gene...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Chen FQ,Sun YH,Zhou SY,Li TY,Chen R

更新日期：2011-10-17 00:00:00

abstract：BACKGROUND:Gastric cancer remains a major cause of mortality and morbidity worldwide. In recent years, gene-based therapeutic strategies were confirmed promising in cancer inhibition and attracted great attention. RNA interference (RNAi) is a powerful tool for gene therapy and has been widely employed to aid in treatme...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Peng H,Yang H,Song L,Zhou Z,Sun J,Du Y,Lu K,Li T,Yin A,Xu J,Wei S

更新日期：2016-03-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Sheng W,Shi X,Lin Y,Tang J,Jia C,Cao R,Sun J,Wang G,Zhou L,Dong M

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. Despite advances in diagnosis and treatment, the p...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhao Y,Zhu J,Shi B,Wang X,Lu Q,Li C,Chen H

更新日期：2019-07-11 00:00:00

abstract：:The aim of this study was to assess the nuclear/cytoplasmic (N/C) ratio using computerized image analysis of cervical smears with intraepithelial neoplasia (CIN) grade I to III associated or not with cellular changes of human papillomavirus (HPV) in an attempt to determine if this method is more sensitive for the esti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Athanassiadou P,Kavantzas N,Gonidi M,Athanassiades P,Liossi A,Nakopoulou L,Petrakakou E,Davaris P

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Viscum album L. extracts (VAE, European mistletoe) are a widely used medicinal plant extract in gynaecological and breast-cancer treatment. METHODS:Systematic review to evaluate clinical studies and preclinical research on the therapeutic effectiveness and biological effects of VAE on gynaecological and bre...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kienle GS,Glockmann A,Schink M,Kiene H

更新日期：2009-06-11 00:00:00

abstract：BACKGROUND:Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of various human tumors. With this work we intended to investigate the expression and promoter methylation...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Z,Wang Y,Fang J,Chen F,Liu J,Wu J,Wang Y

更新日期：2010-03-24 00:00:00

abstract：BACKGROUND:When a patient concomitantly uses two or more drugs, a drug-drug interaction (DDI) can possibly occur, potentially leading to an increased or decreased clinical effect of a given treatment. Cancer patients are at high risk of such interactions because they commonly receive multiple medications. Moreover, mos...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ussai S,Petelin R,Giordano A,Malinconico M,Cirillo D,Pentimalli F

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating plasmin production. The aim of this study was to investigate the potential uti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lokman NA,Ho R,Gunasegaran K,Bonner WM,Oehler MK,Ricciardelli C

更新日期：2019-01-08 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical results, a certain percentage of patients do not respond to this kind of immunotherapy. In addition, in a fra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Camelliti S,Le Noci V,Bianchi F,Moscheni C,Arnaboldi F,Gagliano N,Balsari A,Garassino MC,Tagliabue E,Sfondrini L,Sommariva M

更新日期：2020-11-09 00:00:00

abstract：:Radiofrequency Thermal Ablation (RFA) of liver tumors is done by percutaneous, laparoscopic and open surgical approach. Selection criteria for percutaneous or open surgical ablation of 65 hepatic lesions are here evaluated in 45 patients treated in a two-years period. Twenty-five patients were males and 20 females, ag...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Crucitti A,Danza FM,Antinori A,Vincenzo A,Pirulli PG,Bock E,Magistrelli P

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numerous cancers. However, the underlying mechanisms by which CAF-derived exosomes promote tumor progress...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang X,Qin X,Yan M,Shi J,Xu Q,Li Z,Yang W,Zhang J,Chen W

更新日期：2019-04-08 00:00:00

abstract：UNLABELLED:PCR analysis has been demonstrated as a valuable tool for detection of minimal residual disease (MRD) in lymphoid malignancies. However, the finding that patients with evidence of MRD sometimes remain in long-lasting remission directs further investigations toward biology of residual disease and/or quantific...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cikota BM,Tukić LJ,Tarabar OT,Magić ZM

更新日期：2007-12-01 00:00:00

abstract：:We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

更新日期：2000-09-01 00:00:00