Abstract：
:This protocol describes the efficient, generally applicable Ullmann coupling reaction of bromaminic acid with alkyl- or aryl-amines in phosphate buffer under microwave irradiation using elemental copper as a catalyst. The reaction leads to a number of biologically active compounds. As a prototypical example, the synthesis of a new, potent antagonist of human platelet P2Y(12) receptors, which has potential as an antithrombotic drug, is described in detail. The optimized protocol includes a description of an appropriate reaction setup, thin layer chromatography for monitoring the reaction and a procedure for the isolation, purification and characterization of the anticipated product. The reaction is performed without the use of a glove box and there is no requirement for an inert atmosphere. The reaction typically proceeds within 2-30 min, the protocol, including workup, generally takes 1-3 h to complete.
journal_name
Nat Protocjournal_title
Nature protocolsauthors
Baqi Y,Müller CEdoi
10.1038/nprot.2010.63subject
Has Abstractpub_date
2010-05-01 00:00:00pages
945-53issue
5eissn
1754-2189issn
1750-2799pii
nprot.2010.63journal_volume
5pub_type
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