Diminished prevalence but preserved synaptic distribution of N-methyl-D-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain.

abstract：:It has previously been demonstrated, in dual probe microdialysis studies, that stimulation of the neostriatum with kainic acid causes the release of GABA both locally within the neostriatum and distally in the substantia nigra, observations that are consistent with the known anatomy of the basal ganglia. The object of...

journal_title：Neuroscience

authors： Bianchi L,Colivicchi MA,Bolam JP,Della Corte L

更新日期：1998-11-01 00:00:00

abstract：:Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the striatum. We have previously reported that cocaine inhibits the DAT within 4-5 s of i.v. injection, matching the temporal profile of the behavior...

journal_title：Neuroscience

authors： Yorgason JT,Jones SR,España RA

更新日期：2011-05-19 00:00:00

abstract：:Extracellular nucleotides exert their actions via two subfamilies of purinoceptors: P2X and P2Y. Eight mammalian P2Y receptor subtypes (P2Y(1,2,4,6,11,12,13,14)) have been identified. In this work, the localization of P2Y(6) was studied in rat retina using double immunofluorescence labeling and confocal scanning micro...

journal_title：Neuroscience

authors： Zhang PP,Yang XL,Zhong YM

更新日期：2012-09-18 00:00:00

abstract：:It is well established that task complexity can affect both performance and brain processing. Event-related potentials (ERPs) studies have shown modulation of the well-known N2 and P3 components. However, limited information is available on the recently described frontal components associated with processing within th...

journal_title：Neuroscience

authors： Mussini E,Berchicci M,Bianco V,Perri RL,Quinzi F,Di Russo F

更新日期：2020-11-21 00:00:00

abstract：:Efficient synaptic vesicle membrane recycling is one of the key factors required to sustain neurotransmission. We investigated potential differences in the compensatory endocytic machineries in two glutamatergic synapses with phasic and tonic patterns of activity in the lamprey spinal cord. Post-embedding immunocytoch...

journal_title：Neuroscience

authors： Evergren E,Zotova E,Brodin L,Shupliakov O

更新日期：2006-08-11 00:00:00

abstract：:4-Aminopyridine (4-AP) is suggested to improve symptomatology of spinal injury patients because it may facilitate neuromuscular transmission, spinal impulse flow and the operation of the locomotor central pattern generator (CPG). Since 4-AP can also induce repetitive discharges from dorsal root afferents, this phenome...

journal_title：Neuroscience

authors： Taccola G,Nistri A

更新日期：2005-01-01 00:00:00

abstract：:The projections of the nucleus of the diagonal band of Broca and of the substantia innominata to the cerebral cortex were studied in the rat, using the anterograde transport of wheat germ agglutinin conjugated with horseradish peroxidase. Following diagonal band injections, fibers were observed ascending in the septum...

journal_title：Neuroscience

authors： Lamour Y,Dutar P,Jobert A

更新日期：1984-06-01 00:00:00

abstract：:Developmental alterations in GABAergic synaptic transmission were examined physiologically and biochemically in hippocampus of rats from 3 days of age to adulthood. Neither antidromic nor orthodromic stimulation could elicit identifiable inhibitory postsynaptic potentials in CA1 neurons in slices from rats 5 or 6 days...

journal_title：Neuroscience

authors： Swann JW,Brady RJ,Martin DL

更新日期：1989-01-01 00:00:00

abstract：:Mature neurons contain two distinct regulated secretory pathways, characterized electron microscopically by so-called large dense core vesicles and small synaptic vesicles, respectively. Each vesicle type is characterized by vesicle-specific proteins, such as the granins (chromogranins/secretogranins) for the matrix o...

journal_title：Neuroscience

authors： Tixier-Vidal A,Barret A,Faivre-Bauman A,Huttner W,Wiedenmann B

更新日期：1992-01-01 00:00:00

abstract：:Mutations in the presenilin 1 and 2 genes cause the majority of early onset familial forms of Alzheimer's disease. Here we describe the biochemical and immunohistochemical characterization of calsenilin, a novel calcium binding protein that we have previously shown to interact with presenilins 1 and 2, in mouse brain....

journal_title：Neuroscience

authors： Zaidi NF,Berezovska O,Choi EK,Miller JS,Chan H,Lilliehook C,Hyman BT,Buxbaum JD,Wasco W

更新日期：2002-01-01 00:00:00

abstract：:Neuronal oscillations are important for information processing. The entorhinal cortex is one of the structures which is involved in generation of theta rhythm. The major role of the entorhinal cortex is to feed diverse sources of information both to and from the hippocampus. Far from simply being a funnel for this inf...

journal_title：Neuroscience

authors： Schmitz D,Gloveli T,Behr J,Dugladze T,Heinemann U

更新日期：1998-08-01 00:00:00

abstract：:This study examines the proposal that striatonigral pathways support circling mediated by dopamine D1 receptors, but not D2 receptors, in unilaterally 6-hydroxydopamine-treated rats. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and...

journal_title：Neuroscience

authors： Fletcher GH,Starr MS

更新日期：1987-12-01 00:00:00

abstract：:Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...

journal_title：Neuroscience

authors： Bakker J,Baum MJ,Slob AK

更新日期：1996-09-01 00:00:00

abstract：:Vascular endothelial cells were activated during acute ischemic brain injury, which could induce neural progenitor cell proliferation and migration. However, the mechanism was still unknown. In the current study, we explored whether vascular endothelial cells promoted neural progenitor cell proliferation and whether m...

journal_title：Neuroscience

authors： Zhou S,Gao B,Sun C,Bai Y,Cheng D,Zhang Y,Li X,Zhao J,Xu D

更新日期：2020-08-10 00:00:00

abstract：:Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulat...

journal_title：Neuroscience

authors： Bredewold R,Schiavo JK,van der Hart M,Verreij M,Veenema AH

更新日期：2015-10-29 00:00:00

abstract：:The uptake and release of catecholamines was investigated in the isolated perfused adrenal gland of the rat after preloading the preparation with [3H]norepinephrine, and the effects of various agents were examined on the stimulation-evoked secretion of catecholamines and total tritium. Large quantities of tritium were...

journal_title：Neuroscience

authors： Wakade AR,Malhotra RK,Wakade TD,Dixon WR

更新日期：1986-08-01 00:00:00

abstract：:Neurotransmitter and headache target localization in the trigeminal ganglia (TG) might increase the understanding of sites of action, and mechanisms related to headache therapy. The overall aim of the study was to investigate the presence of migraine targets in the TG with particular emphasis on pituitary adenylate cy...

journal_title：Neuroscience

authors： Frederiksen SD,Warfvinge K,Ohlsson L,Edvinsson L

更新日期：2018-11-21 00:00:00

abstract：:Amyloid deposits in Alzheimer's disease, Down's syndrome and aged brain are composed largely of A beta protein, which is generated by proteolytic processing of beta-amyloid precursor protein. Proteases responsible for liberating the A beta protein from the precursor have not yet been identified. Here, we examined the ...

journal_title：Neuroscience

authors： Savage MJ,Iqbal M,Loh T,Trusko SP,Scott R,Siman R

更新日期：1994-06-01 00:00:00

abstract：:While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implanted with autologous uterus in the gastrocnemius muscle. Withi...

journal_title：Neuroscience

authors： Alvarez P,Chen X,Hendrich J,Irwin JC,Green PG,Giudice LC,Levine JD

更新日期：2012-12-06 00:00:00

abstract：:In rats anaesthetized with ketamine, rhythmic jaw-opening and jaw-closing movements were induced by palatal stimulation. The two masseter muscles (jaw-closing) and the four digastric muscles (jaw-opening) were fitted with electrodes, which could be used either for electrical stimulation or for recording electromyograp...

journal_title：Neuroscience

authors： van Willigen JD,Jüch PJ,Ballintijn CM,Broekhuijsen ML

更新日期：1986-10-01 00:00:00

abstract：:Distribution of primary afferent fibers was studied in intact and neonatally capsaicin treated rats by the application of horseradish peroxidase to the central branch of the transected lumbar dorsal roots. Coarse primary afferent fibers entered the spinal cord through the larger medial portion of the rootlet and arbor...

journal_title：Neuroscience

authors： Réthelyi M,Salim MZ,Jancsó G

更新日期：1986-07-01 00:00:00

abstract：:The action of mastoparan (a wasp venom peptide) on "maxi" Ca(2+)-activated K+ channels was studied in excised inside-out patch recordings from cultured bovine chromaffin cells, under normal conditions (160 mM K+ inside, 154 mM Na+ outside). Mastoparan, when applied on the intracellular side of the membrane reduced the...

journal_title：Neuroscience

authors： Glavinović MI,Joshi A,Trifaró JM

更新日期：1992-10-01 00:00:00

abstract：:Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...

journal_title：Neuroscience

authors： Luo C,Kumamoto E,Furue H,Chen J,Yoshimura M

更新日期：2002-01-01 00:00:00

abstract：:Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson's disease have provided evidence for pathologically exaggerated oscillatory beta-band activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance ima...

journal_title：Neuroscience

authors： Florin E,Dafsari HS,Reck C,Barbe MT,Pauls KA,Maarouf M,Sturm V,Fink GR,Timmermann L

更新日期：2013-06-14 00:00:00

abstract：:Undifferentiated PC12 cells undergo apoptosis, via a calcium-induced calcium release mechanism, when the calcium-binding protein purified from bovine brain (native S100) is present in micromolar concentration in the medium. This process begins when S100 binds to specific membrane binding sites and involves up to 50% o...

journal_title：Neuroscience

authors： Fulle S,Mariggiò MA,Belia S,Petrelli C,Ballarini P,Guarnieri S,Fanò G

更新日期：1999-03-01 00:00:00

abstract：:In the cerebral cortex, the voltage-gated potassium channel, Kv3.1b, a splicing variant of Kv3.1, has been associated with fast-firing interneurons. Here, we report strong expression of Kv3.1b-protein and mRNA in both Betz and Meynert pyramidal cells of the monkey, as shown by immunohistochemistry and in situ hybridiz...

journal_title：Neuroscience

authors： Ichinohe N,Watakabe A,Miyashita T,Yamamori T,Hashikawa T,Rockland KS

更新日期：2004-01-01 00:00:00

abstract：:Previous studies suggested that Group I metabotropic glutamate (mGlu) receptors play a role in mechanotransduction processes of slowly adapting type I mechanoreceptors. Using an isolated rat sinus hair follicle preparation we tested a range of compounds. Surprisingly, only non-competitive mGlu1 receptor antagonists pr...

journal_title：Neuroscience

authors： Cahusac PM,Mavulati SC

更新日期：2009-10-20 00:00:00

abstract：:Conduction time is typically ignored in computational models of neural network function. Here we consider the effects of conduction delays on the synchrony of neuronal activity and neural oscillators, and evaluate the consequences of allowing conduction velocity (CV) to be regulated adaptively. We propose that CV vari...

journal_title：Neuroscience

authors： Pajevic S,Basser PJ,Fields RD

更新日期：2014-09-12 00:00:00

abstract：:Parvalbumin is a calcium-binding protein which is thought to play a role in neuronal excitability. In the cerebral cortex parvalbumin is largely found in two subsets of GABAergic neurons, the chandelier and basket cells. A distinguishing characteristic of the chandelier cell is that the terminal portions of its axon f...

journal_title：Neuroscience

authors： Fonseca M,Soriano E,Ferrer I,Martinez A,Tuñon T

更新日期：1993-08-01 00:00:00

abstract：:The present paper looks for kinematic similarities between whole-body and arm movements executed in the sagittal plane. Eight subjects performed sit-to-stand (STS) and back-to-sit (BTS) movements at their preferred speed in the sagittal plane. Kinematics analysis focused on shoulder motion revealed that STS was compos...

journal_title：Neuroscience

authors： Papaxanthis C,Dubost V,Pozzo T

更新日期：2003-01-01 00:00:00