Abstract:
:Dr Tamar Ben-Yedidia has more than 15 years of experience in the field of immunology, with specific expertise in the development of vaccines. She started her career with Biotechnology General Ltd (BTG; Rehovot, Israel), working on the development of a recombinant hepatitis B vaccine. She joined the Weizmann Institute of Science (Rehovot, Israel) in 1994 and, under the auspices of Professor Ruth Arnon in the Department of Immunology, worked on the design of a peptide-based vaccine against several pathogens, focusing on influenza. Dr Ben-Yedidia received her PhD from the Weizmann Institute after completion of her doctoral thesis entitled 'A Peptide-Based Vaccine Against Influenza'. She continued this work when she left the Weizmann Institute in 2005 to join BiondVax (Ness Ziona, Israel). She was involved in two European Consortium projects related to the evaluation of different approaches for vaccination in which leading laboratories in the field participated. She is often invited to address conferences around the world and has published around 20 refereed articles and invited reviews in various renowned scientific journals. In this interview, Dr Tamar Ben-Yedidia speaks to Commissioning Editor Duc Le.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Ben-Yedidia Tdoi
10.1586/erv.10.2subject
Has Abstractpub_date
2010-03-01 00:00:00pages
241-2issue
3eissn
1476-0584issn
1744-8395journal_volume
9pub_type
面试abstract:INTRODUCTION:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide. Vaccination against HIV requires generation of memory T cells and neutralizing antibodies, mucosal immunity, and stimulation of an inn...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2018.1534588
更新日期:2018-11-01 00:00:00
abstract::Several new TB vaccines are currently undergoing clinical trials. Among the most promising is a vaccine based upon the modified vaccinia virus Ankara-expressing mycobacterial antigen 85A (MVA85A). Given the widespread use of the current TB vaccine, BCG, many of the new TB vaccines are being tested for their ability to...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.11.144
更新日期:2011-12-01 00:00:00
abstract::Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates glo...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1068125
更新日期:2015-01-01 00:00:00
abstract::Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold. CpG motifs promote the production of T-helper 1 and pro-inflammatory cytokines and induce the maturation/activation of professional antigen-presen...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.2.305
更新日期:2003-04-01 00:00:00
abstract:INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1745070
更新日期:2020-04-01 00:00:00
abstract::Influenza vaccines remain the primary public health tool in reducing the ever-present burden of influenza and its complications. In seeking more immunogenic, more effective and more broadly cross-protective influenza vaccines, the landscape of influenza vaccines is rapidly expanding, both in near-term advances and nex...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.13.35
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2016.1254044
更新日期:2016-12-01 00:00:00
abstract::There is growing interest in immunotherapy for malignant gliomas. This interest stems from a number of immunological observations, together with the failure of conventional therapeutic agents to produce broad and clinically meaningful improvements in survival and quality of life. The challenges faced in translating la...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2014.881255
更新日期:2014-03-01 00:00:00
abstract::Vaccine distribution and delivery has become an issue of significant interest, given the threat of a pandemic influenza outbreak and the resulting need for coordinated efforts to distribute and deliver pandemic influenza vaccines into the hands of healthcare workers responsible for administering them. This review prov...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.6.981
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a globally prevalent disease despite remaining susceptible to penicillin treatment. Syphilis vaccine development is a viable preventative approach that will serve to complement public health-oriented syphilis prevent...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2016.1203262
更新日期:2017-01-01 00:00:00
abstract::Highly renowned in the vaccines world, Stanley A. Plotkin has worked at many leading institutions throughout his career, and is Emeritus Professor of the University of Pennsylvania and Adjunct Professor of the Johns Hopkins University. In 1991, Plotkin joined Sanofi Pasteur and worked there from 1991 to 1997, and now ...
journal_title:Expert review of vaccines
pub_type: 面试
doi:10.1586/14760584.2014.934678
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:Streptococcus pneumoniae causes mucosal and invasive diseases with high morbidity and mortality. Introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) into routine infant immunization programs worldwide resulted in serotype 19A becoming a leading cause of the remaining pneumococcal disease bur...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2017.1362339
更新日期:2017-10-01 00:00:00
abstract::Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buru...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.4.561
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Patent and proprietary medicine vendors (PPMVs) are widespread in communities and can potentially be used to expand access to routine immunization especially in underserved areas. In this study, we aimed to assess their readiness to implement routine immunization in Kano, Nigeria and identify factors associa...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1750379
更新日期:2020-04-01 00:00:00
abstract::Baculovirus and insect cell culture technologies have mostly been limited to research laboratories for the transient expression of target proteins for drug development purposes. With the renaissance of the vaccine field and the regulatory acceptance of recombinant DNA technology, the baculovirus expression system has ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.24
更新日期:2011-07-01 00:00:00
abstract::The Leishmania donovani glycoprotein fraction, known as FML, successfully underwent preclinical and clinical (Phase I-III) vaccine trials against canine visceral leishmaniasis (92-95% of protection and 76-80% of vaccine efficacy) when formulated with a QS21 saponin-containing adjuvant. It became the licensed Leishmune...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.7.6.833
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION:It has been almost fifty years since the Towne strain was used by Plotkin and collaborators as the first vaccine candidate for cytomegalovirus (CMV). While that approach showed partial efficacy, there have been a multitude of challenges to improve on the promise of a CMV vaccine. Efforts have been dichotom...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2018.1526085
更新日期:2018-10-01 00:00:00
abstract::Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine for...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.57
更新日期:2011-05-01 00:00:00
abstract::Group A Streptococcus (GAS) infections are a significant global cause of morbidity and mortality. GAS diseases disproportionally affect those living in conditions characterized by poverty and social injustice, in both developing countries and in marginalized populations of industrialized nations. In Australia and New ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1116946
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Dendritic cells (DCs) regulate mucosal T-cell immunity and encounter several distinct bacteria of the gut flora, including lactobacilli. Gram-positive lactobacilli have been suggested to play an important role in exerting adjuvanticity effects on innate immune cells at mucosal sites. AIMS & METHODS:In the p...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.7.8.1155
更新日期:2008-10-01 00:00:00
abstract::The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/erv.11.34
更新日期:2011-04-01 00:00:00
abstract::Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we currently lack a safe and effective pneumonic plague vaccine. These facts raise concern that Y. pestis may be exploited as a bioweapon...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.2.209
更新日期:2008-03-01 00:00:00
abstract::The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established the method of in vitro reassembly of SV40 virus-like particles (SV40-VLPs) from VP1-pentamers. In this reassembly, SV40-VLPs can encapsulate approximately 5 kb exogenous DNA shielded by h...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.12.149
更新日期:2013-02-01 00:00:00
abstract::Introduction: Controlling the preventable infectious diseases is the main goal of vaccination. Among the vaccines, combined vaccines are of great importance for their social, public health, and economic values. It is stated that the combined vaccines are as efficient and safe as the monovalent vaccines. However, a con...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1843434
更新日期:2020-10-01 00:00:00
abstract::Many vaccine candidates are highly purified, sometimes monomeric antigens and as a result, not very immunogenic. Antigen delivery systems optimize the presentation of antigens. They also play a major role in solving the problem of there being an increasing number of vaccines but limited opportunities in which to inclu...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.4.453
更新日期:2004-08-01 00:00:00
abstract::Several subtypes of influenza A viruses with pandemic potential are endemic in bird populations throughout Asia, Africa and the Middle East, and evidence suggests that these viruses are adapting to the mammalian host. As emphasized by the high mortality rate of humans infected with H5N1 viruses, this situation present...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.13.21
更新日期:2013-04-01 00:00:00
abstract::Introduction: For over 40 years, ebolaviruses have been responsible for sporadic outbreaks of severe and often fatal hemorrhagic fever in humans and nonhuman primates across western and central Africa. In December 2013, an unprecedented Ebola virus (EBOV) epidemic began in West Africa and resulted in the largest outbr...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2020.1738225
更新日期:2020-03-01 00:00:00
abstract::Bordetella pertussis, responsible for one of the oldest vaccine-preventable diseases in children, has resurged in North America, Europe, Latin America and many countries around the world. Despite new recommended vaccination strategies for adolescents, pregnant women and adults, mortality is still significant in develo...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.10.156
更新日期:2011-01-01 00:00:00
abstract::Vaccine manufacturing processes are designed to meet present and upcoming challenges associated with a growing vaccine market and to include multi-use facilities offering a broad portfolio and faster reaction times in case of pandemics and emerging diseases. The final products, from whole viruses to recombinant viral ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1067144
更新日期:2015-01-01 00:00:00
abstract::Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, remains a major cause of morbidity and mortality worldwide. The presence of chronic respiratory illness is a major risk factor for pneumonia, and smoking (the most common cause of chronic obstructive pulmonary disease) is also an importan...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.176
更新日期:2012-02-01 00:00:00