Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats.

Abstract:

:The objective of this study was to determine the impact of treadmill locomotor training on the expression of insulin-like growth factor I (IGF1) and changes in myogenic regulatory factors (MRFs) in rat soleus muscle following spinal cord injury (SCI). Moderate, midthoracic (T(8)) contusion SCIs were produced using a NYU (New York University) impactor. Animals were randomly assigned to treadmill training or untrained groups. Rats in the training group were trained starting at 1 week after SCI, for either 3 bouts of 20 min over 1.5 days or 10 bouts over 5 days. Five days of treadmill training completely prevented the decrease in soleus fiber size resulting from SCI. In addition, treadmill training triggered increases in IGF1, MGF and IGFBP4 mRNA expression, and a concurrent reduction of IGFBP5 mRNA in skeletal muscle. Locomotor training also caused an increase in markers of muscle regeneration, including small muscle fibers expressing embryonic myosin and Pax7 positive nuclei and increased expression of the MRFs, myogenin and MyoD. We concluded that treadmill locomotor training ameliorated muscle atrophy in moderate contusion SCI rats. Training-induced muscle regeneration and fiber hypertrophy following SCI was associated with an increase in IGF1, an increase in Pax7 positive nuclei, and upregulation of MRFs.

journal_name

Eur J Appl Physiol

authors

Liu M,Stevens-Lapsley JE,Jayaraman A,Ye F,Conover C,Walter GA,Bose P,Thompson FJ,Borst SE,Vandenborne K

doi

10.1007/s00421-010-1392-z

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

709-20

issue

4

eissn

1439-6319

issn

1439-6327

journal_volume

109

pub_type

杂志文章
  • Arm insulation and swimming in cold water.

    abstract::To test whether adding insulation to the arms would improve cold water swimming performance by delaying swimming failure (SF). Novice (n = 7) and expert (n = 8) swimmers, clothed and equipped with a personal flotation device, each performed two trials in a swimming flume filled with 10 degrees C water. During free swi...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-008-0690-1

    authors: Lounsbury DS,Ducharme MB

    更新日期:2008-09-01 00:00:00

  • Effects of step duration in incremental ramp protocols on peak power and maximal oxygen consumption.

    abstract:PURPOSE:Morton (J Sport Sci 29:307-309, 2011) proposed a model of the peak power attained in ramp protocol ([Formula: see text]) that included critical power (CP) and anaerobic capacity as constants, and mean ramp slope (S) as variable. Our hypothesis is that [Formula: see text] depends only on S, so that Morton's mode...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-013-2705-9

    authors: Adami A,Sivieri A,Moia C,Perini R,Ferretti G

    更新日期:2013-10-01 00:00:00

  • Experimental evaluation of eye-blink parameters as a drowsiness measure.

    abstract::Drowsiness and increased tendency to fall asleep during daytime is still a generally underestimated problem. An increased tendency to fall asleep limits the efficiency at work and substantially increases the risk of accidents. Reduced alertness is difficult to assess, particularly under real life settings. Most of the...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-003-0807-5

    authors: Caffier PP,Erdmann U,Ullsperger P

    更新日期:2003-05-01 00:00:00

  • Exercise after heart transplantation.

    abstract::Exercise intolerance in heart transplant recipients (HTR) has a multifactorial origin, involving complex interactions among cardiac, neurohormonal, vascular, skeletal muscle and pulmonary abnormalities. However, the role of these abnormalities may differ as a function of time after transplantation and of many other va...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00421-003-0952-x

    authors: Marconi C,Marzorati M

    更新日期:2003-10-01 00:00:00

  • Aqua cycling for immunological recovery after intensive, eccentric exercise.

    abstract:PURPOSE:Alterations in immunological homeostasis induced by acute exercise have been frequently reported. In view of the growing amount of repetitive exercise stimuli in competitive sports, quick recovery plays a superior role. Therefore, we examined whether aqua cycling affects cellular immunological recovery. METHOD...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-019-04127-4

    authors: Joisten N,Walzik D,Schenk A,Bloch W,Zimmer P,Wahl P

    更新日期:2019-06-01 00:00:00

  • Effects of glutamine and hyperoxia on pulmonary oxygen uptake and muscle deoxygenation kinetics.

    abstract::The aim of the present study was to determine whether glutamine ingestion, which has been shown to enhance the exercise-induced increase in the tricarboxylic acid intermediate (TCAi) pool size, resulted in augmentation of the rate of increase in oxidative metabolism at the onset of exercise. In addition, the potential...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-006-0324-4

    authors: Marwood S,Bowtell JL

    更新日期:2007-01-01 00:00:00

  • Only lower limb controlled interactive computer gaming enables an effective increase in energy expenditure.

    abstract::Limited research documents if new and existing interactive computer gaming "exergaming" increase energy expenditure and cardio-respiratory costs comparable to common exercise modalities. To address this, healthy male volunteers (n = 15) completed six by 12-min test elements: PlayStation2 (PS2(hand)), Nintendo Wii boxi...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-010-1773-3

    authors: Jordan M,Donne B,Fletcher D

    更新日期:2011-07-01 00:00:00

  • Muscle sympathetic nerve activity at rest compared to exercise tolerance.

    abstract::Cardiovascular autonomic function is associated with physical performance and exercise training adaptation. The association between physical performance and sympathetic regulation is not well known. We hypothesized that sympathetic nervous system activity is associated with physical performance among male runners. The...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-007-0618-1

    authors: Hautala AJ,Kiviniemi AM,Mäkikallio TH,Tiinanen S,Seppänen T,Huikuri HV,Tulppo MP

    更新日期:2008-03-01 00:00:00

  • Effect of non-uniform skin temperature on thermoregulatory response during water immersion.

    abstract::The present study investigated the effect of non-uniform skin temperature distribution on thermoregulatory responses and subjective thermal sensation during water immersion. Ten healthy male subjects carried out 60 min water immersion twice, once with uniform (UST) and once with non-uniform (NUST) skin temperature. In...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-008-0714-x

    authors: Wakabayashi H,Kaneda K,Sato D,Tochihara Y,Nomura T

    更新日期:2008-09-01 00:00:00

  • Comparison of two waist-mounted and two ankle-mounted electronic pedometers.

    abstract::This study compared two ankle-mounted pedometers [StepWatch 3 (SW-3(Ankle)) and Activity Monitoring Pod 331 (AMP(Ankle))] and two waist-mounted pedometers [New Lifestyles NL-2000 (NL(Waist)) and Digiwalker SW-701 (SW-701(Waist))] under controlled and free-living conditions. In part I, 20 participants walked on a tread...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-005-0018-3

    authors: Karabulut M,Crouter SE,Bassett DR Jr

    更新日期:2005-10-01 00:00:00

  • Prescribing 6-weeks of running training using parameters from a self-paced maximal oxygen uptake protocol.

    abstract:PURPOSE:The self-paced maximal oxygen uptake test (SPV) may offer effective training prescription metrics for athletes. This study aimed to examine whether SPV-derived data could be used for training prescription. METHODS:Twenty-four recreationally active male and female runners were randomly assigned between two trai...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-018-3814-2

    authors: Hogg JS,Hopker JG,Coakley SL,Mauger AR

    更新日期:2018-05-01 00:00:00

  • A 20-min nap in athletes changes subsequent sleep architecture but does not alter physical performances after normal sleep or 5-h phase-advance conditions.

    abstract:PURPOSE:The aim of the study was to examine the effects of a post-prandial 20 min nap on a short-term physical exercise and subsequent sleep in athletes keeping their usual sleep schedules and in 5-h phase-advance condition. METHODS:Sixteen healthy young male athletes (age 22.2 ± 1.7 years, non-habitual nappers) parti...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-013-2776-7

    authors: Petit E,Mougin F,Bourdin H,Tio G,Haffen E

    更新日期:2014-02-01 00:00:00

  • Effects on dogs of surface-induced hypothermia and rewarming on the right heart function and pulmonary circulation.

    abstract::Hypothermia is commonly found in accidents on land and at sea, yet its pulmonary circulatory effects have not been studied before. To study the effects of hypothermia on the right heart function and pulmonary circulation, cardiac catheterization was carried out on nine anaesthetized beagle dogs. The dogs were cooled b...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s004210050059

    authors: Palo M,Lauri T,Timisjärvi J

    更新日期:2000-03-01 00:00:00

  • Effects of strength training with eccentric overload on muscle adaptation in male athletes.

    abstract::In classic concentric/eccentric exercise, the same absolute load is applied in concentric and eccentric actions, which infers a smaller relative eccentric load. We compared the effects of 6 weeks of classic concentric/eccentric quadriceps strength training (CON/ECC, 11 subjects) to eccentric overload training (CON/ECC...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-009-1292-2

    authors: Friedmann-Bette B,Bauer T,Kinscherf R,Vorwald S,Klute K,Bischoff D,Müller H,Weber MA,Metz J,Kauczor HU,Bärtsch P,Billeter R

    更新日期:2010-03-01 00:00:00

  • Changes in spring-mass model characteristics during repeated running sprints.

    abstract::This study investigated fatigue-induced changes in spring-mass model characteristics during repeated running sprints. Sixteen active subjects performed 12 × 40 m sprints interspersed with 30 s of passive recovery. Vertical and anterior-posterior ground reaction forces were measured at 5-10 m and 30-35 m and used to de...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-010-1638-9

    authors: Girard O,Micallef JP,Millet GP

    更新日期:2011-01-01 00:00:00

  • Two methods for determining plasma IL-6 in humans at rest and following exercise.

    abstract::We compared two methods to determine IL-6 at rest and following exercise. On two occasions, plasma IL-6 was determined in 10 men and 13 women before and immediately following 90 min of cycling at 65% V(O)(2max) using a cytometric bead array (CBA) and an ELISA. The CBA detected IL-6 in 63% of pre-exercise samples and 8...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-008-0866-8

    authors: Timmons BW,Hamadeh MJ,Tarnopolsky MA

    更新日期:2009-01-01 00:00:00

  • Consistency of perceptual and metabolic responses to a laboratory-based simulated 4,000-m cycling time trial.

    abstract::Although pacing-related research is widely reported, no studies have described the consistency of pacing strategies or their associated energetic contributions. This study aimed to investigate the consistency of pacing and energetic outlay by establishing the typical within and between trial variations during simulate...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-010-1818-7

    authors: Stone MR,Thomas K,Wilkinson M,St Clair Gibson A,Thompson KG

    更新日期:2011-08-01 00:00:00

  • Measurement frequency influences the rating of perceived exertion during sub-maximal treadmill running.

    abstract::To examine the influence of the frequency of measurement on the rating of perceived exertion (RPE) during sub-maximal exercise. On two occasions participants performed 35 min sub-maximal treadmill exercise at the same running speed. In both runs RPE was measured after 5 min. Thereafter, RPE was measured at either 10-m...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-009-1041-6

    authors: Corbett J,Vance S,Lomax M,Barwood MJ

    更新日期:2009-05-01 00:00:00

  • Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction.

    abstract::We hypothesized that impaired cardiovascular responses to isometric muscle action contribute to the cardiovascular deconditioning that occurs after space flight (SF) and head-down-tilt bed rest (HDT). Six subjects were studied before, during and after 120 days of -6 degrees HDT, and four subjects were studied before, ...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s004210100429

    authors: Spaak J,Sundblad P,Linnarsson D

    更新日期:2001-07-01 00:00:00

  • Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity.

    abstract::The protective effect of short-term creatine supplementation (CrS) upon markers of strenuous contractile activity-induced damage in human and rat skeletal muscles was investigated. Eight Ironman triathletes were randomized into the placebo (Pl; n = 4) and creatine-supplemented (CrS; n = 4) groups. Five days prior to t...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-009-1305-1

    authors: Bassit RA,Pinheiro CH,Vitzel KF,Sproesser AJ,Silveira LR,Curi R

    更新日期:2010-03-01 00:00:00

  • Genomic and non-genomic effects of aldosterone on the individual variation of the sweat Na+ concentration during exercise in trained athletes.

    abstract::To clarify whether the resting background effects (genomic) or exercise-related action (non-genomic) of aldosterone (ALD) is primarily affected to an individual variation in the sweat Na+ concentration ([Na+]sweat), we analyzed the cross-sectional relationship between [Na+]sweat and the plasma ALD concentration during...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-006-0295-5

    authors: Yoshida T,Shin-ya H,Nakai S,Yorimoto A,Morimoto T,Suyama T,Sakurai M

    更新日期:2006-11-01 00:00:00

  • Exercise-induced changes in circulating levels of transforming growth factor-beta-1 in humans: methodological considerations.

    abstract::Mechanical loading of cells induces the expression of transforming growth factor-beta-1, and acute exercise, which involves mechanical loading of several tissues, could thus increase its circulating level in humans. However, no consensus exists regarding the plasma concentration of this cytokine in resting subjects (r...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-003-0881-8

    authors: Heinemeier K,Langberg H,Kjaer M

    更新日期:2003-09-01 00:00:00

  • Assessment of cerebral oxygenation during prolonged simulated driving using near infrared spectroscopy: its implications for fatigue development.

    abstract::Information on cerebral oxygenation during prolonged driving in healthy humans may help to explain the cause and development of central fatigue and its effects on cortex activities. The objective of this study is to investigate the time course of cerebral oxygenation during a prolonged driving task. Forty healthy male...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-009-1122-6

    authors: Li Z,Zhang M,Zhang X,Dai S,Yu X,Wang Y

    更新日期:2009-10-01 00:00:00

  • Leg-press resistance training during 20 days of 6 degrees head-down-tilt bed rest prevents muscle deconditioning.

    abstract::The purpose of this study was to investigate the effects of resistance training on the morphological and functional properties of human lower limb muscles during 20 days of 6 degrees head-down-tilt bed rest. Nine men were randomly assigned to the resistance training group (BR-Tr, n = 5) or the non-training, control gr...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s004210050648

    authors: Akima H,Kubo K,Kanehisa H,Suzuki Y,Gunji A,Fukunaga T

    更新日期:2000-05-01 00:00:00

  • Neuromuscular assessment in elderly workers with and without work related shoulder/neck trouble: the NEW-study design and physiological findings.

    abstract::Musculoskeletal disorders in the neck and shoulder area are a major occupational concern in the European countries especially among elderly females. The aim was to assess these disorders based on quantitative EMG indicators and functional tests. 252 female computer users (45-68 years) were recruited from four European...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-005-0042-3

    authors: Sjøgaard G,Søgaard K,Hermens HJ,Sandsjö L,Läubli T,Thorn S,Vollenbroek-Hutten MM,Sell L,Christensen H,Klipstein A,Kadefors R,Merletti R

    更新日期:2006-01-01 00:00:00

  • Effect of vibration frequency on agonist and antagonist arm muscle activity.

    abstract:PURPOSE:This study aimed to assess the effect of vibration frequency (f out) on the electromyographic (EMG) activity of the biceps brachii (BB) and triceps brachii (TB) muscles when acting as agonist and antagonist during static exercises with different loads. METHODS:Fourteen healthy men were asked to hold a vibrator...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-015-3108-x

    authors: Rodríguez Jiménez S,Benítez A,García González MA,Moras Feliu G,Maffiuletti NA

    更新日期:2015-06-01 00:00:00

  • Responses of growth hormone aggregates to different intermittent exercise intensities.

    abstract::The purpose of this study was to determine the impact of high-intensity intermittent exercise on the presence of circulating growth hormone (GH) aggregates measured using two different assay techniques. Six male subjects with endurance training background participated in this study under both exercise and no-exercise ...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-002-0774-2

    authors: Rubin MR,Kraemer WJ,Kraemer RR,Durand RJ,Acevedo EO,Johnson LG,Castracane VD,Scheett TP,French DN,Volek JS

    更新日期:2003-04-01 00:00:00

  • Interstitial glucose concentration in insulin-resistant human skeletal muscle: influence of one bout of exercise and of local perfusion with insulin or vanadate.

    abstract::The present study investigated the changes occurring in interstitial metabolite concentrations and blood flow in insulin-resistant human skeletal muscle during the post-exercise recovery period following a single 2-h bout of one-legged exercise. In addition, the effect of microdialysis perfusion with insulin or the in...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-008-0753-3

    authors: Hamrin K,Henriksson J

    更新日期:2008-07-01 00:00:00

  • Upper trapezius muscle mechanomyographic and electromyographic activity in humans during low force fatiguing and non-fatiguing contractions.

    abstract::The purposes of this study were firstly to compare and investigate localised fatigue in the upper trapezius muscle in various arm positions as assessed by mechanomyographic (MMG) and surface electromyographic (EMG) signals and secondly to study the effects of different normalisation methods on MMG and EMG signals duri...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-002-0655-8

    authors: Madeleine P,Farina D,Merletti R,Arendt-Nielsen L

    更新日期:2002-08-01 00:00:00

  • Peak and submaximal steady-state metabolic and cardiorespiratory responses during arm-powered and arm-trunk-powered handbike ergometry in able-bodied participants.

    abstract::The purpose of this study was to compare the peak and submaximal metabolic and cardiorespiratory responses during steady-state arm-powered (AP) and arm-trunk-powered (ATP) handbike ergometry. Twelve male able-bodied participants with no prior experience in handcycling completed a maximal progressive incremental test a...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-011-2051-8

    authors: Verellen J,Meyer C,Janssens L,Vanlandewijck Y

    更新日期:2012-03-01 00:00:00