Abstract:
:The objective of this study was to determine the impact of treadmill locomotor training on the expression of insulin-like growth factor I (IGF1) and changes in myogenic regulatory factors (MRFs) in rat soleus muscle following spinal cord injury (SCI). Moderate, midthoracic (T(8)) contusion SCIs were produced using a NYU (New York University) impactor. Animals were randomly assigned to treadmill training or untrained groups. Rats in the training group were trained starting at 1 week after SCI, for either 3 bouts of 20 min over 1.5 days or 10 bouts over 5 days. Five days of treadmill training completely prevented the decrease in soleus fiber size resulting from SCI. In addition, treadmill training triggered increases in IGF1, MGF and IGFBP4 mRNA expression, and a concurrent reduction of IGFBP5 mRNA in skeletal muscle. Locomotor training also caused an increase in markers of muscle regeneration, including small muscle fibers expressing embryonic myosin and Pax7 positive nuclei and increased expression of the MRFs, myogenin and MyoD. We concluded that treadmill locomotor training ameliorated muscle atrophy in moderate contusion SCI rats. Training-induced muscle regeneration and fiber hypertrophy following SCI was associated with an increase in IGF1, an increase in Pax7 positive nuclei, and upregulation of MRFs.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Liu M,Stevens-Lapsley JE,Jayaraman A,Ye F,Conover C,Walter GA,Bose P,Thompson FJ,Borst SE,Vandenborne Kdoi
10.1007/s00421-010-1392-zsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
709-20issue
4eissn
1439-6319issn
1439-6327journal_volume
109pub_type
杂志文章abstract::To test whether adding insulation to the arms would improve cold water swimming performance by delaying swimming failure (SF). Novice (n = 7) and expert (n = 8) swimmers, clothed and equipped with a personal flotation device, each performed two trials in a swimming flume filled with 10 degrees C water. During free swi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0690-1
更新日期:2008-09-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-013-2705-9
更新日期:2013-10-01 00:00:00
abstract::Drowsiness and increased tendency to fall asleep during daytime is still a generally underestimated problem. An increased tendency to fall asleep limits the efficiency at work and substantially increases the risk of accidents. Reduced alertness is difficult to assess, particularly under real life settings. Most of the...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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abstract::Exercise intolerance in heart transplant recipients (HTR) has a multifactorial origin, involving complex interactions among cardiac, neurohormonal, vascular, skeletal muscle and pulmonary abnormalities. However, the role of these abnormalities may differ as a function of time after transplantation and of many other va...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-06-01 00:00:00
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journal_title:European journal of applied physiology
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0618-1
更新日期:2008-03-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0714-x
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210050059
更新日期:2000-03-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-009-1292-2
更新日期:2010-03-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-010-1638-9
更新日期:2011-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0866-8
更新日期:2009-01-01 00:00:00
abstract::Although pacing-related research is widely reported, no studies have described the consistency of pacing strategies or their associated energetic contributions. This study aimed to investigate the consistency of pacing and energetic outlay by establishing the typical within and between trial variations during simulate...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-010-1818-7
更新日期:2011-08-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-009-1305-1
更新日期:2010-03-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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更新日期:2003-09-01 00:00:00
abstract::Information on cerebral oxygenation during prolonged driving in healthy humans may help to explain the cause and development of central fatigue and its effects on cortex activities. The objective of this study is to investigate the time course of cerebral oxygenation during a prolonged driving task. Forty healthy male...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1122-6
更新日期:2009-10-01 00:00:00
abstract::The purpose of this study was to investigate the effects of resistance training on the morphological and functional properties of human lower limb muscles during 20 days of 6 degrees head-down-tilt bed rest. Nine men were randomly assigned to the resistance training group (BR-Tr, n = 5) or the non-training, control gr...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s004210050648
更新日期:2000-05-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-005-0042-3
更新日期:2006-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0753-3
更新日期:2008-07-01 00:00:00
abstract::The purposes of this study were firstly to compare and investigate localised fatigue in the upper trapezius muscle in various arm positions as assessed by mechanomyographic (MMG) and surface electromyographic (EMG) signals and secondly to study the effects of different normalisation methods on MMG and EMG signals duri...
journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00