Ten days vs. 14 days antibiotic therapy in culture-proven neonatal sepsis.

Abstract:

BACKGROUND:There are no evidence-based guidelines for the treatment of neonatal sepsis although standard text books recommend 14 days of antibiotics for blood culture-proven neonatal sepsis. OBJECTIVE:The present study compared the effectiveness of a 10-day course of antibiotic therapy with the conventional 14-day course in blood culture-proven neonatal sepsis. METHODS:Infants ≥ 32 weeks and ≥ 1.5 kg weight with blood culture-proven sepsis were randomized to either 10-day (study group) or 14-day (control group) therapy on Day 7 of appropriate antibiotic therapy, if they were in clinical remission and were C-Reactive Protein (CRP) negative. The primary outcome was treatment failure within 28 days defined by either positive CRP or positive blood culture or clinical relapse. RESULTS:The baseline characteristics were comparable between the two groups. There was one treatment failure in each group. The duration of hospital stay was significantly shorter in the 10-day treatment group. CONCLUSION:Ten-day antibiotic therapy is as effective as 14-day therapy in blood culture-proven neonatal sepsis, if the infant has achieved clinical remission by Day 7 of therapy.

journal_name

J Trop Pediatr

authors

Gathwala G,Sindwani A,Singh J,Choudhry O,Chaudhary U

doi

10.1093/tropej/fmq012

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

433-5

issue

6

eissn

0142-6338

issn

1465-3664

pii

fmq012

journal_volume

56

pub_type

杂志文章,随机对照试验
  • Endocrine functions in sickle cell anaemia patients.

    abstract::In this study, 80 male and female sickle cell patients, aged 4-50 years, with mild (severity index, SI < 6) and severe (SI > or = 6) forms of the disease were investigated). The levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, cortisol, growth hormone (GH), free thyroxine (T4), and...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/38.6.307

    authors: el-Hazmi MA,Bahakim HM,al-Fawaz I

    更新日期:1992-12-01 00:00:00

  • Concurrent outbreak of leptospirosis and dengue in Mumbai, India, 2002.

    abstract::This prospective study was undertaken to investigate the possibility of a concurrent outbreak of leptospirosis and dengue and to describe the clinical illnesses. From 20 June to 14 November 2002, children who presented to our hospital with a suspected diagnosis of leptospirosis or dengue were admitted. In every child ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmh100

    authors: Karande S,Gandhi D,Kulkarni M,Bharadwaj R,Pol S,Thakare J,De A

    更新日期:2005-06-01 00:00:00

  • Lysozyme levels for the diagnosis of tuberculous effusions in children.

    abstract::Lysozyme level was measured in the fluid and serum of 42 tuberculous (25 pleural, 11 ascites and 6 pericardial) and 29 non-tuberculous (5 malignant, 9 empyema thoracis, 10 transudative ascites and 5 pyopericardium) effusions. The mean fluid lysozyme level was significantly raised in tuberculous pleural, ascites, and p...

    journal_title:Journal of tropical pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1093/tropej/46.5.296

    authors: Mishra OP,Yusuf S,Ali Z,Nath G

    更新日期:2000-10-01 00:00:00

  • Clinical and epidemiological characteristics of pandemic influenza A/(H1N1) in hospitalized pediatric patients at a university hospital, Istanbul, Turkey.

    abstract:BACKGROUND:The aim of this study was to describe the clinical and epidemiological characteristics of pandemic influenza in hospitalized children. METHODS:A total of 114 patients with suspected H1N1 virus infection were hospitalized, and nasal swabs were sent to National Influenza Reference Laboratory for confirmation ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmq075

    authors: Torun SH,Somer A,Salman N,Ciblak M,Demirkol D,Kanturvardar M,Badur S,Devecioğlu Ö

    更新日期:2011-06-01 00:00:00

  • Role of HCV coinfection towards disease progression and survival in HIV-1 infected children: a follow-up study of 10 years.

    abstract::The present study was taken up to evaluate the pattern of disease progression and survival in a group of HIV-1 positive children, coinfected with HCV infection (n=25) in comparison to those without such coinfection (n=23). There was a significant negative correlation between the rate of decline of the CD4 + T cell per...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmi103

    authors: Shivraj SO,Chattopadhya D,Grover G,Kumar A,Baveja UK

    更新日期:2006-06-01 00:00:00

  • Is a booster dose necessary in children after immunization with live attenuated Japanese encephalitis vaccine?

    abstract::Japanese encephalitis virus is a common cause of encephalitis in Asian children; therefore, maintenance of immunity against Japanese encephalitis virus is essential. Although many countries recommend booster vaccination, some trials have concluded that administration of one or two vaccinations is sufficient. The curre...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmt043

    authors: Choi UY,Lee SY,Kim KH,Kim DS,Choi KM,Cha SH,Kang JH

    更新日期:2013-10-01 00:00:00

  • Case Series of Infantile Tremor Syndrome in Tertiary Care Paediatric Centre from Southern India.

    abstract:Introduction:Infantile tremor syndrome (ITS) is characterized by anaemia, skin depigmentation, tremors and developmental delay. The lack of sufficient literature on ITS and its conflicting association with vitamin B12 deficiency made us present this article. Objective:The objective of this study is to describe demogra...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmx062

    authors: Gowda VK,Kolli V,Benakappa A,Srinivasan VM,Shivappa SK,Benakappa N

    更新日期:2018-08-01 00:00:00

  • Seroepidemiology of rubella in Saudi Arabia.

    abstract::The seroepidemiology of infection due to rubella virus in Saudi Arabia was investigated in various age groups including unvaccinated children (newborn to 15 years of age) using a newer rubella antibody test system, the ELISA with maximum sensitivity and reliability. The assessment of the immune status indicated the lo...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.4.169

    authors: Hossain A

    更新日期:1989-08-01 00:00:00

  • Designing colour-coded measuring tapes based on mid-arm and chest circumference to predict low birth weight in the field.

    abstract:BACKGROUND:In developing countries, 80% of the births take place in the community. METHODS:Birthweight, mid-arm and chest circumferences were measured in 294 newborns admitted in a tertiary-level hospital in Kolkata between April and August 2010. Colour-coded measuring tapes were devised using receiver operating chara...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmr004

    authors: Ghosh M,Das S,Chakraborty S,Chatterjee R

    更新日期:2011-12-01 00:00:00

  • Clinical and anthropometric profile of children with celiac disease in Punjab (North India).

    abstract::This prospective study was carried out to evaluate the clinical and anthropometric profile of 71 children confirmed to have celiac disease on the basis of clinical features, duodenal biopsy and unequivocal improvement on gluten-free diet. Serological tests were performed in 35 cases. The patients were divided into thr...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmi054

    authors: Pooni PA,Chhina RS,Jaina BK,Singh D,Gautam A

    更新日期:2006-02-01 00:00:00

  • Bacteremia and malaria in Tanzanian children hospitalized for acute febrile illness.

    abstract::We recorded the reason for presentation to a rural hospital in an area endemic for malaria in 909 children between January 2006 and March 2009. Blood smears were examined for Plasmodium falciparum parasites, and blood spots dried on filter paper were prepared for 464 children. A PCR assay utilizing the stored blood sp...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmu069

    authors: Lundgren IS,Heltshe SL,Smith AL,Chibwana J,Fried MW,Duffy PE

    更新日期:2015-04-01 00:00:00

  • Henoch-Schonlein purpura: clinical experience and contemplations on a streptococcal association.

    abstract::Henoch-Schonlein Purpura (HSP) is a common cause of vasculitis in children. The role of an antecedent streptococcal infection is still controversial. The aim of this study is to verify such a relationship, as well as to provide a profile of the clinical features and the magnitude of this disorder in Jordan. We identif...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/42.4.200

    authors: al-Sheyyab M,el-Shanti H,Ajlouni S,Batieha A,Daoud AS

    更新日期:1996-08-01 00:00:00

  • Diarrhoea mortality in rural Bangladeshi children.

    abstract::Diarrhoeal mortality and hospital admissions for diarrhoea are described among children under the age of 5 years in a large rural Bangladeshi community during 1986-87. Acute watery (dehydrating) diarrhoea was associated with 11 per cent of all deaths among infants aged 1-11 months and 5 per cent among children aged 1-...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/37.1.31

    authors: Fauveau V,Yunus M,Zaman K,Chakraborty J,Sarder AM

    更新日期:1991-02-01 00:00:00

  • Using three delays model to understand the social factors responsible for neonatal deaths in rural Haryana, India.

    abstract:OBJECTIVE:To investigate causes of and contributors to newborn deaths in rural Haryana using a three delays audit approach. METHODS:The study was conducted in 28 villages under the rural field practice area of the Comprehensive Rural Health Services Project, All India Institute of Medical Sciences situated in Ballabga...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fms060

    authors: Upadhyay RP,Rai SK,Krishnan A

    更新日期:2013-04-01 00:00:00

  • Factors Associated with Stunting among Pre-school Children in Southern Highlands of Tanzania.

    abstract:BACKGROUND:Stunting is a major public health problem in Africa and is associated with poor child survival and development. We investigate factors associated to child stunting in three Tanzanian regions. METHODS:A cross-sectional two-stage cluster sampling survey was conducted among children aged 6-59 months. The sampl...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmw024

    authors: Altare C,Delbiso TD,Mutwiri GM,Kopplow R,Guha-Sapir D

    更新日期:2016-10-01 00:00:00

  • Screening programme for phenylketonuria in the Gaza Strip: evaluation and recommendations.

    abstract::Phenylketonruia (PKU) is an inherited metabolic disorder that results in progressive mental retardation. PKU is a paradigm of a disease that can be identified by proper screening of newborns and medical follow-up in order to prevent serious complications. The present study was designed to evaluate the Palestinian nati...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/50.2.101

    authors: Abu Shahla AN,Abed Y,Abu Shahla NK

    更新日期:2004-04-01 00:00:00

  • Use of Artificial Nipples Among Brazilian Infants and Associated Factors.

    abstract::Transversal study conducted in a Human Milk Bank to evaluate the factors associated with the use of artificial nipples (pacifier and/or nursing bottle) among Brazilian infants. Analyses were performed using the χ2 test and logistic regression analysis. A total of 6017 nursing mothers were evaluated and the use of arti...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmaa007

    authors: Miranda C,de Sousa TM,do Carmo AS,Pereira SCL,Notaro KAM,Dos Santos LC

    更新日期:2020-10-01 00:00:00

  • CD4+ T-lymphocyte count/CD8+ T-lymphocyte count ratio: surrogate for HIV infection in infants?

    abstract:INTRODUCTION:Early diagnosis and treatment is necessary to prevent HIV-infected infants progressing to AIDS. Antibody testing is not confirmatory before the age of 18 months and PCR not widely available in resource-poor settings. We studied the accuracy of CD4(+) T-lymphocyte count, CD4% and CD4/CD8 ratio as surrogate ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmr102

    authors: Navaneethapandian PG,Karunaianantham R,Subramanyan S,Chinnayan P,Chandrasekaran P,Swaminathan S

    更新日期:2012-10-01 00:00:00

  • Association between functional gastrointestinal diseases and exposure to abuse in teenagers.

    abstract::Abdominal pain-predominant functional gastrointestinal diseases (AP-FGD) are common in children and commonly attributed to exposure to child abuse. However, this relationship has not been studied in teenagers, and the main objective of the current study was to assess it. Teenagers were recruited from four randomly sel...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmu035

    authors: Devanarayana NM,Rajindrajith S,Perera MS,Nishanthanie SW,Karunanayake A,Benninga MA

    更新日期:2014-10-01 00:00:00

  • Characterisation of beta-globin gene mutations in Malaysian children: a strategy for the control of beta-thalassaemia in a developing country.

    abstract::beta-thalassaemia major, an autosomal recessive hemoglobinopathy, is one of the most common single gene disorders in multi-racial Malaysia. The control of beta-thalassaemia major requires a multi-disciplinary approach that includes population screening, genetic counselling, prenatal diagnosis and the option of termina...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmi052

    authors: Thong MK,Tan JA,Tan KL,Yap SF

    更新日期:2005-12-01 00:00:00

  • Improved pediatric weighing device for use with portable hanging scales.

    abstract::Portable hanging scales are a common means of weighing young children. Weighing trousers used to suspend children from a hanging scale are uncomfortable and require insertion of the child's legs through the trousers. The 'weighing seat' holds the child in a more natural, comfortable, and secure position, thus increasi...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/46.2.117

    authors: Murãmoto ML

    更新日期:2000-04-01 00:00:00

  • Obstacles to achieving immunization for all 2000: missed immunization opportunities and inappropriately timed immunization.

    abstract::Missed opportunities and inappropriately time immunization substantially reduced the coverage achieved in Mozambique and Guinea Conakry. During coverage surveys in Mozambique, we noted dates of attendance at a health facility for growth monitoring or vaccination, and in Conakry we also abstracted dates of curative car...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/37.4.153

    authors: Cutts FT,Zell ER,Soares AC,Diallo S

    更新日期:1991-08-01 00:00:00

  • The role of erythrocyte protoporphyrin in the diagnosis of iron deficiency anemia of children.

    abstract::The values of erythrocyte protoporphyrin, ferritin and mean corpuscular volume (MCV) measurements in diagnosing iron deficiency anemia were investigated in 72 iron deficient and in 25 healthy control infants. Receiver operator curve, sensitivity and specificity of erythrocyte protoporphyrin, ferritin and mean corpuscu...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/46.6.323

    authors: Serdar MA,Sarici SU,Kurt I,Alpay F,Okutan V,Kurnaz L,Kutluay T

    更新日期:2000-12-01 00:00:00

  • Effectiveness of phototherapy units in Cameroon.

    abstract::Neonatal hyperbilirubinemia continues to be a leading cause of morbidity and mortality in resource-limited countries. The aim of this study was to measure the effectiveness of existing phototherapy units at a local hospital in Cameroon using an irradiance meter. Phototherapy units (n = 4) in one newborn nursery in Cam...

    journal_title:Journal of tropical pediatrics

    pub_type: 信件

    doi:10.1093/tropej/fmt110

    authors: Satrom K,Slusher T,Satrom J

    更新日期:2014-06-01 00:00:00

  • Intraventricular haemorrhage in premature infants: a study from Oman.

    abstract::In a prospective study at Sultan Qaboos University Hospital, 95 premature infants with birthweights equal or less than 1500 g were screened for intraventricular haemorrhage (IVH) using cranial ultrasound. Nineteen (20 per cent) were found to have developed IVH. Eight out of fourteen variables studied showed a signific...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/43.3.174

    authors: Bassiouny MR,Remo C,Remo R,Lapitan R

    更新日期:1997-06-01 00:00:00

  • Helicobacter pylori infection and recurrent abdominal pain in children.

    abstract::The association of Helicobacter pylori infection with recurrent abdominal pain (RAP) was studied in 65 children aged between 3 and 12 years. Cases with a specific cause for abdominal pain were excluded from the study. All the patients were subjected to upper gastrointestinal endoscopy and antral biopsy. The biopsy spe...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.4.250

    authors: Das BK,Kakkar S,Dixit VK,Kumar M,Nath G,Mishra OP

    更新日期:2003-08-01 00:00:00

  • Animal Bites and Rabies Prophylaxis in Rural Children: Indian Perspective.

    abstract::A prospective observational study was conducted in a tertiary care hospital to study clinicoepidemiological profile of potentially rabid animal bite cases from rural India. Total of 308 children (median age 6 years) admitted to hospital, were recruited over 1 year and followed up till completion of antirabies vaccine ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmv072

    authors: Samanta M,Mondal R,Shah A,Hazra A,Ray S,Dhar G,Biswas R,Sabui TK,Raychaudhuri D,Chatterjee K,Kundu C,Sarkar S

    更新日期:2016-02-01 00:00:00

  • Ten-year experience with paediatric lymph node tuberculosis in Port Moresby.

    abstract::This is a descriptive study of short-course chemotherapy in children with nodal tuberculosis at Port Moresby General Hospital (PMGH). Between 1 August 1989 and 31 December 1997 5248 children were started on TB treatment. In the retrospective study 427 children were treated for lymph node TB up to 31 December 1996. Of ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/47.3.160

    authors: McMaster P,Ezeilo N,Freisen H,Pomat N,Vince JD

    更新日期:2001-06-01 00:00:00

  • Dietary adequacy of Indian rural preschool children--influencing factors.

    abstract::The dietary adequacy (qualitative and quantitative) of preschool children residing in rural areas near Mysore (a district in south India) was assessed by the 'Food frequency method' and '24-h recall method'. Food intake assessed in three different seasons revealed that their diets were predominantly cereal based with ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmh072

    authors: Lakshmi AJ,Khyrunnisa B,Saraswathi G,Jamuna P

    更新日期:2005-02-01 00:00:00

  • Salmonella septicaemias in Kenyan children.

    abstract::In a 5-month study of Salmonella septicaemias in Kenyan children carried out during the annual peak infection period, Salmonella typhimurium septicaemias occurred seven times more frequently than typhoid or other non-typhoid infections. Salmonella typhimurium infections were predominantly community acquired, malnouris...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.1.35

    authors: Nesbitt A,Mirza NB

    更新日期:1989-02-01 00:00:00