Abstract:
BACKGROUND:There are no evidence-based guidelines for the treatment of neonatal sepsis although standard text books recommend 14 days of antibiotics for blood culture-proven neonatal sepsis. OBJECTIVE:The present study compared the effectiveness of a 10-day course of antibiotic therapy with the conventional 14-day course in blood culture-proven neonatal sepsis. METHODS:Infants ≥ 32 weeks and ≥ 1.5 kg weight with blood culture-proven sepsis were randomized to either 10-day (study group) or 14-day (control group) therapy on Day 7 of appropriate antibiotic therapy, if they were in clinical remission and were C-Reactive Protein (CRP) negative. The primary outcome was treatment failure within 28 days defined by either positive CRP or positive blood culture or clinical relapse. RESULTS:The baseline characteristics were comparable between the two groups. There was one treatment failure in each group. The duration of hospital stay was significantly shorter in the 10-day treatment group. CONCLUSION:Ten-day antibiotic therapy is as effective as 14-day therapy in blood culture-proven neonatal sepsis, if the infant has achieved clinical remission by Day 7 of therapy.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Gathwala G,Sindwani A,Singh J,Choudhry O,Chaudhary Udoi
10.1093/tropej/fmq012subject
Has Abstractpub_date
2010-12-01 00:00:00pages
433-5issue
6eissn
0142-6338issn
1465-3664pii
fmq012journal_volume
56pub_type
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