Predicting phenotype from genotype: normal pigmentation.

Abstract:

:Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.

journal_name

J Forensic Sci

authors

Valenzuela RK,Henderson MS,Walsh MH,Garrison NA,Kelch JT,Cohen-Barak O,Erickson DT,John Meaney F,Bruce Walsh J,Cheng KC,Ito S,Wakamatsu K,Frudakis T,Thomas M,Brilliant MH

doi

10.1111/j.1556-4029.2009.01317.x

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

315-22

issue

2

eissn

0022-1198

issn

1556-4029

pii

JFO1317

journal_volume

55

pub_type

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