Abstract:
:Early gene expression studies classified breast tumors into at least three clinically relevant subtypes. Although most current gene signatures are prognostic for estrogen receptor (ER) positive/human epidermal growth factor receptor 2 (HER2) negative breast cancers, few are informative for ER negative/HER2 negative and HER2 positive subtypes. Here we present Gene Expression Prognostic Index Using Subtypes (GENIUS), a fuzzy approach for prognostication that takes into account the molecular heterogeneity of breast cancer. In systematic evaluations, GENIUS significantly outperformed current gene signatures and clinical indices in the global population of patients.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Haibe-Kains B,Desmedt C,Rothé F,Piccart M,Sotiriou C,Bontempi Gdoi
10.1186/gb-2010-11-2-r18subject
Has Abstractpub_date
2010-01-01 00:00:00pages
R18issue
2eissn
1474-7596issn
1474-760Xpii
gb-2010-11-2-r18journal_volume
11pub_type
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