Abstract：
:We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R- and S-methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R-enantiomer concentrations significantly exceeded that of the S-enantiomers (Wilcoxon's test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R-methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P-glycoprotein were associated with the concentrations of R- and S-methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine. No significant association was detected.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Buchard A,Linnet K,Johansen SS,Munkholm J,Fregerslev M,Morling Ndoi
10.1111/j.1556-4029.2009.01278.xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
457-63issue
2eissn
0022-1198issn
1556-4029pii
JFO1278journal_volume
55pub_type
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