Nephrogenic systemic fibrosis: what the hospitalist needs to know.

Abstract:

:Nephrogenic systemic fibrosis (NSF) has now been linked to gadolinium-based contrast (GBC) exposure in those with compromised kidney function, particularly those with end-stage renal disease (ESRD). When ESRD is present, symptoms can be quite devastating for the patient including severe pain and immobility and even death. For those at risk, avoidance of GBC exposure, whenever possible, is absolutely essential to prevent this potentially devastating complication. Identifying those at risk depends in some circumstances on appropriate recognition of renal dysfunction and understanding appropriate use of glomerular filtration rate (GFR) estimation formulas. Although hemodialysis (but not peritoneal dialysis) removes gadolinium, the availability of dialysis should never be used as a justification for GBC use in this high-risk population. Unfortunately there is a lack of a universally effective therapy. Resolution of acute kidney injury (AKI) appears to attenuate disease in most cases, while kidney transplantation has been associated with variable success.

journal_name

J Hosp Med

authors

Fine DM,Perazella MA

doi

10.1002/jhm.493

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

46-50

issue

1

eissn

1553-5592

issn

1553-5606

journal_volume

5

pub_type

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