Abstract：
OBJECTIVES:(a) To review the methacholine tests performed in our laboratory up until 2008; (b) to compare them with previously reported data in 2006 and (c) to examine if the anti-doping rules are meeting the needs of asthmatic athletes who really need bronchodilator treatment. METHODS:Between April 2004 and September 2008, 89 high-level athletes were examined in our laboratory in order to obtain an abbreviated therapeutic use exemption for β-2 agonists. Of these, 50 men (23.31 (7.05) years) and 23 women (20.68 (5.94) years) performed a methacholine inhalation test with increasing concentrations of methacholine (0.025, 0.25, 2.5, 5, 10 and 25 mg/ml) until a fall of 20% in forced expiratory volume in 1 s (FEV(1)) was achieved. RESULTS:31 candidates (42.5%) had a provocative concentration causing a 20% fall in FEV(1) (PC(20)) <2 mg/ml; 12 (16.4%) were between 2 and 4 mg/ml; 8 (11%) between 4.1 and 8 mg/ml and 22 candidates (30.1%) had a PC(20) >8 mg/ml. Seven of the 73 candidates had an obstructive pattern in the spirometry at rest, demonstrated by a FEV(1)% <70% but with a FEV(1) >70% of the reference value. CONCLUSIONS:The anti-doping regulations with respect to β-2 agonists need to be reviewed, and measures should be adopted to include a fall of 70% in FEV(1)% as an obstruction criterion to indicate a bronchodilation test and to extend the criterion for a positive methacholine test to a PC(20) of 8 mg/ml.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Orellana JN,Márquez MDdoi
10.1136/bjsm.2008.056903subject
Has Abstractpub_date
2011-08-01 00:00:00pages
809-12issue
10eissn
0306-3674issn
1473-0480pii
bjsm.2008.056903journal_volume
45pub_type
杂志文章abstract：BACKGROUND:Extremely low weight and rapid changes in weight and body composition have become major concerns in many sports, but sufficiently accurate field methods for body composition assessment in athletes are missing. This study aimed to explore the use of ultrasound methods for assessment of body fat content in ath...
journal_title：British journal of sports medicine
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