Abstract:
:The beneficial effects of hyperoxia have been noted in treatment of several diseases and pathological states. However, the excessive production of ROS under hyperoxic conditions can directly damage cellular macromolecules if the imbalance in antioxidant status exists. Cytochrome P450 (Cyp) 4a14 has an important role in the metabolism of lipids and as a source of ROS in oxidative stress. This study investigated the oxidant/antioxidant status as a response to hyperoxia treatment in liver of young CBA/Hr mice of both sexes and whether the observed response is mediated by Cyp4a14 via PPAR isoforms in a sex-dependent manner. The overexpression of Cyp4a14, lack of both LPO and of 4-hydroxynonenal(HNE)-protein adducts revealed by immunohistochemical analysis in hyperoxia-treated females indicates their greater resistance to hyperoxia compared to males, which is parallelled to changes in PPARbeta/delta and PPARgamma expression. These results suggest the presence of sex-dependent changes in all investigated parameters, which points out sex-related susceptibility towards oxidative stress and hyperoxia treatment of various pathological conditions and diseases.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Sobocanec S,Balog T,Sarić A,Sverko V,Zarković N,Gasparović AC,Zarković K,Waeg G,Macak-Safranko Z,Kusić B,Marotti Tdoi
10.3109/10715760903390820subject
Has Abstractpub_date
2010-02-01 00:00:00pages
181-90issue
2eissn
1071-5762issn
1029-2470pii
10.3109/10715760903390820journal_volume
44pub_type
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