Signalling pathways in the unfolded protein response: development from yeast to mammals.

Abstract:

:The accumulation of unfolded proteins in the endoplasmic reticulum (ER) under ER stress conditions activates a series of homoeostatic responses collectively termed the unfolded protein response (UPR). The UPR is unique in which the molecular mechanisms it uses to transmit signals from the ER lumen to the nucleus are completely different to those used for signalling from the plasma membrane. An ER stress signal is sensed and transmitted across the membrane by a transmembrane protein(s) in the ER. Interestingly, the number of such functional sensors/transducers, ubiquitously expressed, has increased with evolution, for example, one in Saccharomyces cerevisiae, two in Caenorhabditis elegans and Drosophila melanogaster, and three in mammals. Accordingly, mammalian cells are able to cope with ER stress in a more sophisticated manner. Here, I summarize the mechanisms and activation consequences of UPR signalling pathways in yeast, worm, fly and mammalian cells. I also discuss how they have evolved to counteract ER stress effectively.

journal_name

J Biochem

journal_title

Journal of biochemistry

authors

Mori K

doi

10.1093/jb/mvp166

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

743-50

issue

6

eissn

0021-924X

issn

1756-2651

pii

mvp166

journal_volume

146

pub_type

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