Preparation of N,O-carboxymethyl chitosan nanoparticles as an insulin carrier.

Abstract:

:The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles were formed at conditions of 2 mg/ml of NOCC and 1 mg/ml of TPP. It was found that the encapsulation efficiency and process yield decreased with increasing NOCC to TPP weight ratio. Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin. The higher the pH of the phosphate buffered saline, the greater the amount of cumulative release of insulin-loaded NOCC nanoparticles, and thus they could protect insulin from acid.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Lin CC,Lin CW

doi

10.3109/10717540903353090

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

458-64

issue

8

eissn

1071-7544

issn

1521-0464

journal_volume

16

pub_type

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