Abstract:
BACKGROUND:Understanding the relationship between the protein sequence and the 3D structure is a major research area in bioinformatics. The prediction of complete protein tertiary structure based only on sequence information is still an impractical work. This paper aims at revealing the hidden knowledge of the sequence motifs and the local tertiary structure. RESULTS:In this paper, we propose a Super Granule Support Vector Machine (Super GSVM) model to obtain the high quality protein sequence motifs and to predict local tertiary structure information based on purely sequence information. CONCLUSION:The proposed model overcomes the innate shortcoming of using the SVM on such a large data set, which is the inherent computational complexity involved in training support vectors for huge datasets including half million of samples. The satisfactory prediction results show the Super GSVM model generates decent protein sequence clusters and has the ability to capture the hidden sequence-to-structure information. This model also has a strong potential in the application of SVMs on other research areas with huge datasets.
journal_name
BMC Bioinformaticsjournal_title
BMC bioinformaticsauthors
Chen B,Johnson Mdoi
10.1186/1471-2105-10-S11-S15subject
Has Abstractpub_date
2009-10-08 00:00:00pages
S15issn
1471-2105pii
1471-2105-10-S11-S15journal_volume
10 Suppl 11pub_type
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