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Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells.

Abstract：

:Granulocyte-colony stimulating factor (G-CSF) is a growth factor that regulates proliferation, differentiation and survival of hematopoietic progenitor cells. There is growing evidence to suggest that G-CSF exerts a powerful neuroprotective effect in different neurological disorders. However, it has remained to be elucidated if G-CSF has a direct effect on neural stem cells (NSCs). Here, we show that G-CSF could stimulate the proliferation of NSCs and promote their differentiation in vitro. Additionally, we have shown that G-CSF-induced proliferation of NSCs is associated with phosphorylation of STAT3, and the differentiation is linked to altered expression of differentiation-related genes. Remarkably, G-CSF could not initiate the differentiation of NSCs. The added roles of G-CSF in regulating proliferation and differentiation of NSCs as shown in this study would serve as a useful reference in designing new stem cell therapy strategies for promoting brain recovery and repair.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Liu H,Jia D,Fu J,Zhao S,He G,Ling EA,Gao J,Hao A

doi

10.1016/j.neuroscience.2009.09.045

subject

Has Abstract

pub_date

2009-12-29 00:00:00

pages

1521-30

issue

4

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(09)01547-4

journal_volume

164

pub_type

杂志文章

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