Is mobilized peripheral blood comparable with bone marrow as a source of hematopoietic stem cells for allogeneic transplantation from HLA-identical sibling donors? A case-control study.

Abstract:

BACKGROUND:Granulocyte colony-stimulating factor mobilized peripheral blood stem cells are increasingly used instead of bone marrow as a stem cell source for transplantation. Whereas this change is almost complete for autologous transplantation, there are some concerns when considering allogeneic transplants. DESIGN AND METHODS:We performed a retrospective case-control study including 820 adult patients who had received an allogeneic stem cell transplant from an HLA-identical sibling donor. Quality of life (QoL) was assessed in 150 patients using the EORTC Quality of Life Questionnaire C30 (QLQ-C30). RESULTS:There were no statistically significant differences in overall survival at ten years (bone marrow: 48.9% vs. peripheral blood stem cells: 39.8%; p=0.621), transplant-related mortality (bone marrow: 28.9% vs. peripheral blood stem cells: 34.4%; p=0.682) or relapse incidence at 9 years (29.4% vs. 35.2%, respectively; p=0.688). Similar outcomes were maintained independently of the phase of the disease. However, multivariate analysis identified a higher incidence of acute graft-versus-host disease grades II-IV (p: 0.023; Hazard ratio [HR]: 1.41; 95% confidence interval [CI]: 1.05-1.89) and grades III-IV (p: 0.006; HR: 1.89; 95% CI: 1.20-2.98), in the peripheral blood stem cells-stem cell transplant group. As previously described, extensive chronic graft-versus-host disease was also more frequent in the peripheral blood stem cells group (28% vs. 15.6%; p<0.001). Patients transplanted with peripheral blood stem cells had significant impairment of role and social functioning. CONCLUSIONS:Although overall survival was not affected by the stem cell source, peripheral blood stem cell transplants were associated with a higher risk of both acute and chronic GvHD. Global quality of life was similar in both groups, but patients transplanted with peripheral blood stem cells showed worse role and social functioning scores, probably related to the increased incidence of chronic graft-versus-host disease.

journal_name

Haematologica

journal_title

Haematologica

authors

Gallardo D,de la Cámara R,Nieto JB,Espigado I,Iriondo A,Jiménez-Velasco A,Vallejo C,Martín C,Caballero D,Brunet S,Serrano D,Solano C,Ribera JM,de la Rubia J,Carreras E

doi

10.3324/haematol.2009.006924

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

1282-8

issue

9

eissn

0390-6078

issn

1592-8721

pii

94/9/1282

journal_volume

94

pub_type

杂志文章,多中心研究
  • High cure rates in Burkitt lymphoma and leukemia: a Northern Italy Leukemia Group study of the German short intensive rituximab-chemotherapy program.

    abstract::We evaluate the long-term results of a prospective clinical study enrolling more than 100 adult patients with Burkitt lymphoma/leukemia. Depending on extent of disease, treatment consisted of six to eight rituximab infusions and four to six courses of intensive chemotherapy (attenuated in patients aged >55 years) with...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3324/haematol.2013.086827

    authors: Intermesoli T,Rambaldi A,Rossi G,Delaini F,Romani C,Pogliani EM,Pagani C,Angelucci E,Terruzzi E,Levis A,Cassibba V,Mattei D,Gianfaldoni G,Scattolin AM,Di Bona E,Oldani E,Parolini M,Gökbuget N,Bassan R

    更新日期:2013-11-01 00:00:00

  • Autologous blood stem cell transplantation in hematologic malignancies.

    abstract::Circulating stem cells (CSC) are well documented in animals and humans. Though their function in normal conditions remains obscure, autologous CSC seem capable of restoring hemopoiesis after myeloablative treatment. With cell separators CSC may be harvested in adequate number, and collection may be further improved gi...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Majolino I,Scimé R,Indovina A

    更新日期:1990-11-01 00:00:00

  • Recovery of cord blood hematopoietic progenitors after successive freezing and thawing procedures.

    abstract:BACKGROUND AND OBJECTIVES:Cord blood (CB) is a valuable source of stem cells. Most CB units are still cryopreserved in single bags in the world's CB banks. Thawing a single CB unit, dividing it into two parts, expanding the smaller one and refreezing the other would optimize ex vivo expansion of CB progenitors prior to...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Timeus F,Crescenzio N,Saracco P,Doria A,Fazio L,Albiani R,Cordero Di Montezemolo L,Perugini L,Incarbone E

    更新日期:2003-01-01 00:00:00

  • BRCC3 mutations in myeloid neoplasms.

    abstract::Next generation sequencing technologies have provided insights into the molecular heterogeneity of various myeloid neoplasms, revealing previously unknown somatic genetic events. In our cohort of 1444 cases analyzed by next generation sequencing, somatic mutations in the gene BRCA1-BRCA2-containing complex 3 (BRCC3) w...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2014.111989

    authors: Huang D,Nagata Y,Grossmann V,Radivoyevitch T,Okuno Y,Nagae G,Hosono N,Schnittger S,Sanada M,Przychodzen B,Kon A,Polprasert C,Shen W,Clemente MJ,Phillips JG,Alpermann T,Yoshida K,Nadarajah N,Sekeres MA,Oakley K,Ngu

    更新日期:2015-08-01 00:00:00

  • Primary gastric non-Hodgkin's lymphoma in a population-based registry.

    abstract:BACKGROUND:The incidence of primary gastric non-Hodgkin's lymphoma (NHL) appears to have increased worldwide in recent years, and this seems to be confirmed by large-sample population studies. METHODS AND RESULTS:We derived our data from the Lombardy Cancer Registry, which provides the incidence of cancer in the provi...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Pinotti G,Novario R,Berrino F,Bianchi P,Comi MA,Gamba MC,Venco A

    更新日期:1992-09-01 00:00:00

  • Effect of hematologic response on outcome of patients undergoing transplantation for primary amyloidosis: importance of achieving a complete response.

    abstract::Our objective was to determine whether the goal of high-dose therapy should be a partial hematologic response or a complete response. We analyzed 282 consecutive stem cell transplant patients. A partial hematologic response was achieved in 108 patients (38%), and 93 (33%) achieved a complete hematologic response. Surv...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.11413

    authors: Gertz MA,Lacy MQ,Dispenzieri A,Hayman SR,Kumar SK,Leung N,Gastineau DA

    更新日期:2007-10-01 00:00:00

  • Efficacy of central nervous system prophylaxis with stand-alone intrathecal chemotherapy in diffuse large B-cell lymphoma patients treated with anthracycline-based chemotherapy in the rituximab era: a systematic review.

    abstract::Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been perfor...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.229948

    authors: Eyre TA,Djebbari F,Kirkwood AA,Collins GP

    更新日期:2020-07-01 00:00:00

  • Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight.

    abstract::Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and eligibility to donate. Lifestyle behaviors, such as dietary iron intake and physical activity, may influence iron stores and thereby hemoglobin levels. We aimed to inve...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.229450

    authors: Timmer TC,de Groot R,Rijnhart JJM,Lakerveld J,Brug J,Perenboom CWM,Baart MA,Prinsze FJ,Zalpuri S,van der Schoot EC,de Kort WLAM,van den Hurk K

    更新日期:2020-10-01 00:00:00

  • Cholesterol embolism of bone marrow clinically masquerading as systemic or metastatic tumor.

    abstract::A case of cholesterol embolism of bone marrow, concerning the pelvis and lumbar region and clinically masquerading as systemic disease or metastatic tumor, is reported in an 82-year-old man hospitalized for acute onset of reddish purple nodules on the legs and toes, intense myalgia and dorsal vertebral bone pain. The ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Muretto P,Carnevali A,Ansini AL

    更新日期:1991-05-01 00:00:00

  • Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis.

    abstract::Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis i...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.209551

    authors: Tsuboi I,Harada T,Hirabayashi Y,Aizawa S

    更新日期:2019-10-01 00:00:00

  • Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation.

    abstract:BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.12665

    authors: Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

    更新日期:2008-09-01 00:00:00

  • Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival.

    abstract::Umbilical cord blood stem cell transplants are commonly used in adults lacking HLA-identical donors. Delays in hematopoietic recovery contribute to mortality and morbidity. To hasten recovery, we used co-infusion of progenitor cells from a partially matched related donor and from an umbilical cord blood graft (haplo-c...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:10.3324/haematol.2015.138594

    authors: van Besien K,Hari P,Zhang MJ,Liu HT,Stock W,Godley L,Odenike O,Larson R,Bishop M,Wickrema A,Gergis U,Mayer S,Shore T,Tsai S,Rhodes J,Cushing MM,Korman S,Artz A

    更新日期:2016-05-01 00:00:00

  • Competing-risk outcomes after hematopoietic stem cell transplantation from the perspective of time-dependent effects.

    abstract::The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.183012

    authors: Fuerst D,Frank S,Mueller C,Beelen DW,Schetelig J,Niederwieser D,Finke J,Bunjes D,Kröger N,Neuchel C,Tsamadou C,Schrezenmeier H,Beyersmann J,Mytilineos J

    更新日期:2018-09-01 00:00:00

  • Panobinostat as part of induction and maintenance for elderly patients with newly diagnosed acute myeloid leukemia: phase Ib/II panobidara study.

    abstract::This phase Ib/II trial combined the pan-deacetylase inhibitor panobinostat with chemotherapy followed by panobinostat maintenance in elderly patients with newly diagnosed acute myeloid leukemia. Patients with prior history of myelodysplastic syndrome were excluded and 38 evaluable patients were included in the study (...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:10.3324/haematol.2015.129577

    authors: Ocio EM,Herrera P,Olave MT,Castro N,Pérez-Simón JA,Brunet S,Oriol A,Mateo M,Sanz MÁ,López J,Montesinos P,Chillón MC,Prieto-Conde MI,Díez-Campelo M,González M,Vidriales MB,Mateos MV,San Miguel JF,PETHEMA Group.

    更新日期:2015-10-01 00:00:00

  • Different suppression of Ph1 positive hemopoiesis induced by intensive chemotherapy in lymphoid and myeloid blast crisis of CML.

    abstract:BACKGROUND:The suppression of Ph1-positive hemopoiesis is a major goal in the treatment of CML; in this context the CML patients in blast crisis obtaining a complete clinical remission represent a useful model to investigate the behavior of the Ph1-positive and negative clones during bone marrow repopulation after abla...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Guerrasio A,Martinelli G,Ambrosetti A,Falda M,Paolino F,Rege-Cambrin G,Rosso C,Pignatti PF,Gasparini P,Perona G

    更新日期:1991-03-01 00:00:00

  • Factors predicting peripheral blood progenitor cell collection from pediatric donors for allogeneic transplantation.

    abstract:BACKGROUND AND OBJECTIVES:Although several studies have reported on the use of children as donors for peripheral blood progenitor cells (PBPC), no specific characteristics have been identified as predictors of PBPC collection in this population. In this study we analyzed predictive factors for PBPC collection in pediat...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Díaz MA,Sevilla J,de la Rubia J,Verdeguer A,Espigado I,Vicent MG,Pascual MJ,Zamora C,Arrieta R,Serrano D,del Cañizo C,Arbona C,de Arriba F,Bargay J,Brunet S,Sanz MA

    更新日期:2003-08-01 00:00:00

  • Relationship between pharmacokinetic profile of subcutaneously administered alemtuzumab and clinical response in patients with chronic lymphocytic leukemia.

    abstract::Alemtuzumab serum levels and clinical response after subcutaneous administration (10 mg 3 times/week for six weeks) have been explored in 29 chronic lymphocytic leukemia patients receiving the monoclonal antibody as consolidation. Serum concentrations after each administration gradually increased during the first week...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:10.3324/haematol.2010.033159

    authors: Montagna M,Montillo M,Avanzini MA,Tinelli C,Tedeschi A,Visai L,Ricci F,Vismara E,Morra E,Regazzi M

    更新日期:2011-06-01 00:00:00

  • Different effects of HLA disparity on transplant outcomes after single-unit cord blood transplantation between pediatric and adult patients with leukemia.

    abstract::Recent advances in unrelated cord blood transplantation have increased chances and options available in allogeneic stem cell transplantation. The effect of HLA disparity on outcomes after cord blood transplantation was studied recently in mainly pediatric populations. Results showed that HLA matching in combination wi...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2012.076042

    authors: Atsuta Y,Kanda J,Takanashi M,Morishima Y,Taniguchi S,Takahashi S,Ogawa H,Ohashi K,Ohno Y,Onishi Y,Aotsuka N,Nagamura-Inoue T,Kato K,Kanda Y,HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    更新日期:2013-05-01 00:00:00

  • Heterogeneity of BCL6 rearrangements in nodular lymphocyte predominant Hodgkin's lymphoma.

    abstract:BACKGROUND AND OBJECTIVES:Nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) showed recurrent rearrangement of the BCL6 which is gene detected in 48% of cases analyzed by interphase-fluorescent in situ hybridization (FISH). These findings point to a critical role for BCL6 in the development of this distinct Hodg...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Wlodarska I,Stul M,De Wolf-Peeters C,Hagemeijer A

    更新日期:2004-08-01 00:00:00

  • Reticulocyte transferrin receptor (TfR) expression and contribution to soluble TfR levels.

    abstract:BACKGROUND AND OBJECTIVES:Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of these factors on reticulocyte TfR expression in vivo has never been studied. A soluble form of TfR (sTfR) is present ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: R'zik S,Loo M,Beguin Y

    更新日期:2001-03-01 00:00:00

  • Plasma thrombomodulin concentrations in infants and children undergoing cardiac catheterization.

    abstract::Circulating plasma thrombomodulin (TM) is an endothelial cell marker which may reflect endothelial injury. To find out to what extent diagnostic cardiac catheterization irritates vascular endothelium we conducted a prospective study in 91 children. Soluble TM concentrations, along with thrombin generation, were measur...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Vielhaber H,Kehl HG,Kececioglu D,Nowak-Göttl U

    更新日期:1996-09-01 00:00:00

  • Unusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide.

    abstract::Lenalidomide is a very active drug in myelodysplastic syndrome with del (5q). We report such a patient treated with this drug who developed unusual complex cytogenetic abnormalities, which were elucidated by multi-FISH and FISH analysis as jumping translocations involving the long arm of chromosome 5, that resulted in...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.11917

    authors: Eclache V,Da Rocha A,Le Roux G,Fenaux P

    更新日期:2008-02-01 00:00:00

  • Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia.

    abstract:BACKGROUND AND OBJECTIVES:The role of hematopoietic chimerism after allogeneic stem cell transplantation (SCT) for acute leukemia remains controversial. We studied the relationship between hematopoietic chimerism and several prognostic variables on the outcome of SCT in patients with acute leukemia. DESIGN AND METHODS...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Barrios M,Jiménez-Velasco A,Román-Gómez J,Madrigal ME,Castillejo JA,Torres A,Heiniger A

    更新日期:2003-07-01 00:00:00

  • Aberrant DNA methylation profile of chronic and transformed classic Philadelphia-negative myeloproliferative neoplasms.

    abstract::Most DNA methylation studies in classic Philadelphia-negative myeloproliferative neoplasms have been performed on a gene-by-gene basis. Therefore, a more comprehensive methylation profiling is needed to study the implications of this epigenetic marker in myeloproliferative neoplasms. Here, we have analyzed 71 chronic ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2013.084160

    authors: Pérez C,Pascual M,Martín-Subero JI,Bellosillo B,Segura V,Delabesse E,Álvarez S,Larrayoz MJ,Rifón J,Cigudosa JC,Besses C,Calasanz MJ,Cross NC,Prósper F,Agirre X

    更新日期:2013-09-01 00:00:00

  • The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation.

    abstract:BACKGROUND:Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF19...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2008.001149

    authors: Toffalini F,Kallin A,Vandenberghe P,Pierre P,Michaux L,Cools J,Demoulin JB

    更新日期:2009-08-01 00:00:00

  • Dendritic cells: specialized antigen presenting cells.

    abstract::Renewing interest in cancer immunotherapy reflects the excellent results that have been obtained in animal models and the promising results in early clinical trails with dendritic cell (DC) based approaches. The central role that DCs play in the initiation of an immune response raises the possibility of using them to ...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Di Nicola M,Lemoli RM

    更新日期:2000-02-01 00:00:00

  • Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow.

    abstract:BACKGROUND AND OBJECTIVES:Detection of minimal residual disease (MRD) by multiparameter flow cytometry is an emerging prognostic factor in patients with acute myeloid leukemia (AML). The present analysis aimed at improving the applicability of this approach to more patients with AML. DESIGN AND METHODS:Bone marrow sam...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Kern W,Danhauser-Riedl S,Ratei R,Schnittger S,Schoch C,Kolb HJ,Ludwig WD,Hiddemann W,Haferlach T

    更新日期:2003-06-01 00:00:00

  • Cytogenetic characterization of acute myeloid leukemia in Shwachman's syndrome. A case report.

    abstract::We report on a case of acute myeloid leukemia in a 17-year old boy affected by Shwachman Diamond syndrome (SDS). Conventional cytogenetics at diagnosis revealed an abnormal clone with complex karyotypic changes including typical myeloid aberrations, such as monosomy 5, tetrasomy of chromosome 8, trisomy 9, and deletio...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Spirito FR,Crescenzi B,Matteucci C,Martelli MF,Mecucci C

    更新日期:2000-11-01 00:00:00

  • Modulatory effects of mycobacterial heat-shock protein 70 in DNA vaccination against lymphoma.

    abstract:BACKGROUND AND OBJECTIVES:Pathogen-derived molecules are danger signals and are able to activate innate immunity that in turn controls and regulates generation of adaptive immune responses. Mycobacterium tuberculosis heat shock protein 70 (myc HSP70) has been shown to exert a potent adjuvant effect in vaccination again...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Liso A,Benedetti R,Fagioli M,Mariano A,Falini B

    更新日期:2005-01-01 00:00:00

  • Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods.

    abstract::Reduction in minimal residual disease, measured by real-time quantitative PCR or flow cytometry, predicts prognosis in childhood B-cell precursor acute lymphoblastic leukemia. We explored whether cells reported as minimal residual disease by flow cytometry represent the malignant clone harboring clone-specific genomic...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.051383

    authors: Øbro NF,Ryder LP,Madsen HO,Andersen MK,Lausen B,Hasle H,Schmiegelow K,Marquart HV

    更新日期:2012-01-01 00:00:00