Abstract：
:The tumor suppressor p53 has been proposed to bind target promoters upon genotoxic stress. However, recent evidence shows that p53 occupies some target promoters without such stress, suggesting that a negative regulator might render p53 transcriptionally inactive on these promoters. Here we show that calcineurin binding protein 1 (Cabin1) is a negative regulator of p53. Downregulation of Cabin1 induces activation of a subset of p53 target genes. Cabin1 physically interacts with p53 on these target promoters and represses p53 transcriptional activity in the absence of genotoxic stress, by regulating histone modification and p53 acetylation marks. Knockdown of Cabin1 retards cell growth and promotes cell death after DNA damage in a p53-dependent manner. Thus, Cabin1 inhibits p53 function on chromatin in the quiescent state; the presence of inactive p53 on some promoters might allow a prompt response upon DNA damage.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Jang H,Choi SY,Cho EJ,Youn HDdoi
10.1038/nsmb.1657subject
Has Abstractpub_date
2009-09-01 00:00:00pages
910-5issue
9eissn
1545-9993issn
1545-9985pii
nsmb.1657journal_volume
16pub_type
杂志文章abstract：:The Rbfox family of splicing factors regulate alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart and muscle. Rbfox proteins have long been known to bind to the RNA sequence GCAUG with high affinity and specificity, but just half of Rbfox binding sit...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/s41594-020-0409-5
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abstract：:Complex forms of cellular motility, including cell division, organelle trafficking or signal amplification in the auditory system, require strong coordination of the myosin motors involved. The most basic mechanism of coordination is via direct mechanical interactions of individual motor heads leading to modification ...
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.3231
更新日期：2016-06-07 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2005-10-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 已发布勘误
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更新日期：2018-08-01 00:00:00
abstract：:Spliceosomes catalyze the maturation of precursor mRNAs in organisms ranging from yeast to humans. Their catalytic core comprises three small nuclear RNAs (U2, U5 and U6) involved in substrate positioning and catalysis. It has been postulated, but never shown experimentally, that the U2-U6 complex adopts at least two ...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.1672
更新日期：2009-11-01 00:00:00
