Genetic contribution to variation in atherothrombotic phenotypes in the Asian Indian population. The Indian Atherosclerosis Research Study.

abstract：:Per cent aggregation, release and content of adenine nucleotides, and specific radioactivity were evaluated in citrated platelet-rich plasma (PRP) prepared from paired samples of maternal and cord blood. Platelets of newborn infants aggregated normally in response to highdose ADP (20 muM), strong collagen suspensions,...

journal_title：Thrombosis and haemostasis

authors： Corby DG,Zuck TF

更新日期：1976-08-31 00:00:00

abstract：:The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

journal_title：Thrombosis and haemostasis

authors： Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

journal_title：Thrombosis and haemostasis

authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

更新日期：2010-03-01 00:00:00

abstract：:Thrombolytic therapy provides clinical benefit in patients with vascular occlusions, depending upon the organ or limb that is threatened. The impact of therapeutic intervention varies from the quiet alteration of the course of deep vein thrombosis, for which non-life threatening post-phlebitic syndrome can be largely ...

journal_title：Thrombosis and haemostasis

authors： Marder VJ

更新日期：1995-07-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Recent clinical studies have shown that the interruption of platelet function appears to be effective for treatment of coronary occlusive diseases. For this purpose, a Fab fragment of humanized anti-platelet glycoprotein (GP) IIb/IIIa monoclonal antibody (YM 337) that exhibited an in vivo antithrombotic effect without...

journal_title：Thrombosis and haemostasis

authors： Kuwahara M,Sugimoto M,Tsuji S,Miyata S,Nishio K,Kaku S,Suzuki K,Kawasaki T,Yoshioka A

更新日期：1998-07-01 00:00:00

abstract：:The preparation of antithrombin concentrate for clinical use requires a viral inactivation step. In most commercial preparations this is achieved by heat pasteurisation. This process would be expected to alter the conformation of antithrombin from the active native species to an inactive latent (L-form) state (1, 2). ...

journal_title：Thrombosis and haemostasis

authors： Chang WS,Harper PL

更新日期：1997-02-01 00:00:00

abstract：:Viper venoms contain a variety of platelet binding proteins including those which bind to platelet GPIb/GPIX. Most of these proteins inhibit von Willebrand factor mediated platelet agglutination. Here we report the primary structures of unique members of this family, alboaggregins A and B, isolated from Trimeresurus a...

journal_title：Thrombosis and haemostasis

authors： Kowalska MA,Tan L,Holt JC,Peng M,Karczewski J,Calvete JJ,Niewiarowski S

更新日期：1998-03-01 00:00:00

abstract：:Disrupting the CD40-CD40L co-stimulatory pathway reduces atherosclerosis and induces a stable atherosclerotic plaque phenotype that is low in inflammation and high in fibrosis. Therefore, inhibition of the CD40-CD40L pathway is an attractive therapeutic target to reduce clinical complications of atherosclerosis. The C...

journal_title：Thrombosis and haemostasis

authors： Lievens D,Eijgelaar WJ,Biessen EA,Daemen MJ,Lutgens E

更新日期：2009-08-01 00:00:00

abstract：:The aim was to investigate the perioperative risk of ischaemic and bleeding events in patients with coronary stents undergoing cardiac and non-cardiac surgery and how these outcomes are affected by the perioperative use of oral antiplatelet therapy. This was a multicentre, retrospective, observational study conducted ...

journal_title：Thrombosis and haemostasis

authors： Rossini R,Musumeci G,Capodanno D,Lettieri C,Limbruno U,Tarantini G,Russo N,Calabria P,Romano M,Inashvili A,Sirbu V,Guagliumi G,Valsecchi O,Senni M,Gavazzi A,Angiolillo DJ

更新日期：2015-02-01 00:00:00

abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

journal_title：Thrombosis and haemostasis

authors： Kumar R,Béguin S,Hemker HC

更新日期：1995-09-01 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and functional factor X during warfarin co-administration were established to provide means to interpret INRs during argatroban/warfarin co-therapy. Twenty-four subjects rec...

journal_title：Thrombosis and haemostasis

authors： Sheth SB,DiCicco RA,Hursting MJ,Montague T,Jorkasky DK

更新日期：2001-03-01 00:00:00

abstract：:The vast clinical research programme for the direct, oral factor Xa inhibitor rivaroxaban has generated a wealth of data since the first rivaroxaban approval in 2008 for the prevention of venous thromboembolism (VTE) in patients undergoing elective hip or knee replacement surgery. While rivaroxaban is widely used acro...

journal_title：Thrombosis and haemostasis

authors： Cappato R,Welsh R

更新日期：2016-09-28 00:00:00

abstract：:Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphism...

journal_title：Thrombosis and haemostasis

authors： Pomp ER,Doggen CJ,Vos HL,Reitsma PH,Rosendaal FR

更新日期：2009-01-01 00:00:00

abstract：:Syndecan-4 (ryudocan) is a cell-surface heparan sulfate proteoglycan, which plays an important role in a variety of biological functions including regulation of blood coagulation. cell adhesion, and cell growth. In this study, we measured plasma levels of syndecan-4 in patients with acute myocardial infarction using a...

journal_title：Thrombosis and haemostasis

authors： Kojima T,Takagi A,Maeda M,Segawa T,Shimizu A,Yamamoto K,Matsushita T,Saito H

更新日期：2001-05-01 00:00:00

abstract：:Human high molecular weight kininogen (HK), a single chain plasma glycoprotein, serves as a cofactor in the contact system of blood coagulation. After cleavage by human plasma kallikrein, the nonapeptide bradykinin is released. The HK light chain (LC) contains coagulant activity, which requires both the ability to bin...

journal_title：Thrombosis and haemostasis

authors： Kunapuli SP,DeLa Cadena RA,Colman RW

更新日期：1992-04-02 00:00:00

abstract：:Causative mutations in the factor VIII gene of seven unrelated patients with severe haemophilia A were identified using the mutation screening procedure conformation sensitive gel electrophoresis (1) and characterised by direct sequencing. Female family members of all patients had requested either carrier status deter...

journal_title：Thrombosis and haemostasis

authors： Williams IJ,Abuzenadah A,Winship PR,Preston FE,Dolan G,Wright J,Peake IR,Goodeve AC

更新日期：1998-04-01 00:00:00

abstract：:The increased risk for deep vein thrombosis (DVT) after orthopaedic surgery has been well documented as well as hypercoagulable state during both total hip arthroplasty (THA) and total knee replacement (TKR). To investigate the influence of the surgical procedure [posterolateral (PL) or lateral (L) approach for THA, u...

journal_title：Thrombosis and haemostasis

authors： Fedi S,Gori AM,Falciani M,Cellai AP,Aglietti P,Baldini A,Vena LM,Prisco D,Abbate R,Gensini GF

更新日期：1999-06-01 00:00:00

abstract：:Hyperglycaemia impairs fibrinolytic activity on the surface of endothelial cells, but the underlying mechanisms are not fully understood. In this study, we tested the hypothesis that hyperglycaemia causes dysfunction of the endothelial membrane protein annexin A2, thereby leading to an overall reduction of fibrinolyti...

journal_title：Thrombosis and haemostasis

authors： Dai H,Yu Z,Fan X,Liu N,Yan M,Chen Z,Lo EH,Hajjar KA,Wang X

更新日期：2013-06-01 00:00:00

abstract：:Endothelial cell protein C receptor (EPCR) enhances the generation of activated protein C (APC) by the thrombin-thrombomodulin complex. A soluble form of EPCR (sEPCR), which is generated by metalloprotease activity, is present in plasma. The distribution of sEPCR levels in healthy populations is bimodal. Previously, w...

journal_title：Thrombosis and haemostasis

authors： Medina P,Navarro S,Estellés A,Vayá A,Woodhams B,Mira Y,Villa P,Migaud-Fressart M,Ferrando F,Aznar J,Bertina RM,España F

更新日期：2004-05-01 00:00:00

abstract：:Tissue factor (TF), the main initiator of blood coagulation, contributes to the manifestation of disseminated intravascular coagulation following septic shock in meningococcal infection. Since a direct relationship between disease severity and lipopolysaccharide (LPS) concentration in the circulation has been shown, w...

journal_title：Thrombosis and haemostasis

authors： Henriksson CE,Klingenberg O,Ovstebø R,Joø GB,Westvik AB,Kierulf P

更新日期：2005-12-01 00:00:00

abstract：:Nipah virus (NiV) is a highly pathogenic paramyxovirus that was first isolated in 1999 during an outbreak in Malaysia. In contrast to other paramyxoviruses NiV infects many mammalian species. Because of its zoonotic potential, the high pathogenicity and the lack of therapeutic treatment, NiV was classified as a biosaf...

journal_title：Thrombosis and haemostasis

authors： Maisner A,Neufeld J,Weingartl H

更新日期：2009-12-01 00:00:00

abstract：:Thromboelastography (TEG) has been shown to be a valuable point-of-care device for the rapid diagnosis of various bleeding disorders. However, TEG has thus far not been used for the screening for von Willebrand disease (VWD). We evaluated the performance of a modified TEG assay for the laboratory screening of VWD. Thr...

journal_title：Thrombosis and haemostasis

authors： Topf HG,Weiss D,Lischetzki G,Strasser E,Rascher W,Rauh M

更新日期：2011-06-01 00:00:00

abstract：:Autoantibodies to the zwitterionic phospholipid (PL), phosphatidylethanolamine (PE) have been described in patients with thrombotic diseases. Recently, we reported that many antiphosphatidylethanolamine antibodies (aPE) are not specific for PE per se, but are directed to plasma proteins which can bind PE, for example,...

journal_title：Thrombosis and haemostasis

authors： Sugi T,Mclntyre JA

更新日期：1996-09-01 00:00:00

abstract：:Platelets are key players in atherothrombosis. Antiplatelet therapy comprising aspirin alone or with P2Y12-inhibitors are effective for prevention of atherothrombotic complications. However, there is interindividual variability in the response to antiplatelet drugs, leaving some patients at increased risk of recurrent...

journal_title：Thrombosis and haemostasis

authors： Freynhofer MK,Gruber SC,Grove EL,Weiss TW,Wojta J,Huber K

更新日期：2015-08-31 00:00:00

abstract：:Heparin is often used as an adjunct to thrombolytic therapy in order to prevent reocclusion of the patent vessels in patients with thrombotic disease. Controversy exists as to whether heparin is required for effective clot lysis with tissue-type plasminogen activator, while in vitro data and small scale clinical trial...

journal_title：Thrombosis and haemostasis

authors： Burke SE,Lubbers NL,Nelson RA,Henkin J

更新日期：1993-04-01 00:00:00

abstract：:The effect of a basic synthetic peptide, representing the C-terminal region of tissue factor pathway inhibitor (TFPI - Lys254 - Met276), as well as that of the whole protein, on the activity of lipoprotein lipase (LPL) is described. The activity of bovine LPL was measured by chromogenic assay using a water-soluble chr...

journal_title：Thrombosis and haemostasis

authors： Mukherjee M,Kakkar VV

更新日期：1999-12-01 00:00:00

abstract：:We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC (50) of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidase...

journal_title：Thrombosis and haemostasis

authors： Wang YX,Zhao L,Nagashima M,Vincelette J,Sukovich D,Li W,Subramanyam B,Yuan S,Emayan K,Islam I,Hrvatin P,Bryant J,Light DR,Vergona R,Morser J,Buckman BO

更新日期：2007-01-01 00:00:00

abstract：:We studied the effect of purified immunoglobulins (Ig) from 21 patients with antiphospholipid antibodies (aPL) on factor Va degradation by activated protein C (aPC) on cultured human umbilical vein endothelial cells (HUVEC). Sera from patients were tested on an ELISA aPL assay to determine the isotype with aPL activit...

journal_title：Thrombosis and haemostasis

authors： Borrell M,Sala N,de Castellarnau C,Lopez S,Gari M,Fontcuberta J

更新日期：1992-09-07 00:00:00