Abstract：
:Cortical migration defects are often associated with epilepsy. In mesial temporal lobe epilepsy (MTLE), granule cell dispersion (GCD), a migration defect of dentate granule cells, is frequently observed. Little is known how GCD develops and to which extent it contributes to the development of seizure activity. Since the reelin-deficient reeler mouse mutant shows a similar migration defect of dentate cells, we performed a series of studies investigating whether reelin deficiency is involved in GCD development. We show that in MTLE patients and in a mouse model of MTLE, the development of GCD correlates with a loss of the extracellular matrix protein reelin. In addition, we present evidence that GCD occurs in the absence of neurogenesis, thus representing a displacement of mature neurons due to a reelin deficiency. Accordingly, antibody blockade of reelin function in naïve, adult mice induced GCD. Finally, we show that GCD formation can be prevented by infusion of exogenous reelin. In summary, these studies show that in epilepsy reelin dysfunction causes GCD development and that reelin is important for the maintenance of layered structures in the adult brain.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Haas CA,Frotscher Mdoi
10.1007/s00221-009-1948-5subject
Has Abstractpub_date
2010-01-01 00:00:00pages
141-9issue
2eissn
0014-4819issn
1432-1106journal_volume
200pub_type
杂志文章,评审abstract：:Preshaping the digits and orienting the hand when reaching to grasp a distal target is proposed to be optimal when guided by vision. A reach-to-grasp movement to an object in one's own mouth is a natural and commonly used movement, but there has been no previous description of how it is performed. The movement require...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3164-y
更新日期：2012-08-01 00:00:00
abstract：:The control of self-motion is supported by visual, vestibular, and proprioceptive signals. Recent research has shown how these signals interact in the monkey medio-superior temporal area (area MST) to enhance and disambiguate the perception of heading during self-motion. Area MST is a central stage for self-motion pro...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1990-3
更新日期：2010-01-01 00:00:00
abstract：:Spontaneous firing of midbrain reticular formation (MRF) neurons was recorded extracellularly in chronically implanted, behaving cats during steady and transitional states of the sleep-waking cycle. Physiological identification of receiver and/or projection MRF neurons was achieved through orthodromically elicited dis...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238096
更新日期：1982-01-01 00:00:00
abstract：:We studied the potential contribution of postsynaptic mechanisms to the depression of reflex excitability which occurs immediately after a voluntary release from tonic muscle contraction. The excitability of the Soleus (Sol) motor pool was tested at rest and after voluntary muscle relaxation. In both cases the Sol H-r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230904
更新日期：1985-01-01 00:00:00
abstract：:The climbing fibres to the x and lateral c1 zones of the anterior lobe of the cerebellum arise as branches of common stem olivary axons. Anatomical studies have shown that the c1 zone receives its climbing fibres from the dorsal accessory olive (DAO). It has, therefore, been assumed that the x-zone also receives its c...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235868
更新日期：1985-01-01 00:00:00
abstract：:This study represents the first systematic comparison of the relative contributions of auditory and visual feedback to sequence production. Participants learned an isochronous melody that they performed on a keyboard and attempted to perform this sequence at a prescribed rate while auditory and visual feedback were ma...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3289-z
更新日期：2013-01-01 00:00:00
abstract：:To measure dynamic visuo-motor coupling within the two hemispheres, we showed observers an animation of a rotating cup. They indicated with left or right buttons when a fixation dot in the center of the animation changed color. For either hand, response times changed continuously with the irrelevant position of the cu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0781-3
更新日期：2007-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237074
更新日期：1980-01-01 00:00:00
abstract：:Human walking dynamics are typically framed in the context of mechanics and energetics rather than in the context of neuromuscular control. Dynamic walking principles describe one helpful theoretical approach to characterize efficient human walking mechanics over many steps. These principles do not, however, address h...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3708-9
更新日期：2013-12-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229331
更新日期：1990-01-01 00:00:00
abstract：:Previous work in our laboratory has demonstrated that binocular vision makes an important contribution to skilled reaching and grasping movements directed at static targets. In the present study we examine the contribution of binocular vision to interceptive reaching movements. We monitored such movements using a high...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050323
更新日期：1998-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228964
更新日期：1991-01-01 00:00:00
abstract：:Abstract. Although the contribution of binocular vision to reach-to-grasp movements has been extensively studied, it has been largely ignored in locomotion. The aim of these studies was to explore the role of binocular vision during the approach phase and step over the obstacle and the contribution of head movements t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0948-x
更新日期：2002-02-01 00:00:00
abstract：:In healthy subjects, suprathreshold repetitive transcranial magnetic stimulation (rTMS) at frequencies >2 Hz prolongs the cortical silent period (CSP) over the course of the train. This progressive lengthening probably reflects temporal summation of the inhibitory interneurons in the stimulated primary motor cortex (M...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0296-3
更新日期：2006-06-01 00:00:00
abstract：:We investigated the accuracy with which, in the absence of vision, one can reach again a 2D target location that had been previously identified by a guided movement. A robotic arm guided the participant's hand to a target (locating motion) and away from it (homing motion). Then, the participant pointed freely toward t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1833-1
更新日期：2004-07-01 00:00:00
abstract：:Seizure susceptibility waxes and wanes in an apparently circadian manner in many epileptic patients. Fluctuations of melatonin concentration with highest levels during the night and lowest levels in the early morning could be involved in this phenomenon. Therefore, the action of melatonin on epileptic activity was tes...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230052
更新日期：1995-01-01 00:00:00
abstract：:Owing to the flexibility and redundancy of neuromuscular and skeletal systems, humans can trace the same hand trajectory in space with various arm configurations. However, the joint trajectories of typical unrestrained movements tend to be consistent both within and across subjects. In this paper we propose a method t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0039-5
更新日期：2005-12-01 00:00:00
abstract：:Several experiments have suggested that similar physiological substrates are involved in movement execution and motor imagery, and that the same laws of movement control apply to both processes. Using a mental chronometry paradigm, we examined the effects of movement direction and added mass on the duration of actual ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1012-1
更新日期：2002-04-01 00:00:00
abstract：:A simple model of the vestibuloocular reflex and the optokinetic system was used to simulate recent data on visual and vestibular responses of neurons in the vestibular nucleus. Contrary to a previous interpretation, the results support the hypothesis that the optokinetic and semicircular canal signals are combined si...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237269
更新日期：1977-11-24 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050711
更新日期：1999-04-01 00:00:00
abstract：:This study was undertaken to elucidate neural control of the arterial blood pressure (ABP) in head-down postural change which causes both stimulation to the vestibular system and head-ward fluid shift. Experiments were carried out with urethane-anesthetized rabbits. The animal was mounted on a tilting table, tilted to...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1732-6
更新日期：2009-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235276
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236850
更新日期：1986-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248791
更新日期：1987-01-01 00:00:00
abstract：:Slow eye movements were observed while the monkey fixated on a subject-stationary, small target light in front of a moving optokinetic drum in an attempt to suppress optokinetic nystagmus (OKN). These slow eye movements of low amplitude were directed opposite to the moving optokinetic stimulus and, hence, were not ide...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248564
更新日期：1987-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227650
更新日期：1996-11-01 00:00:00
abstract：:Impaired plantar flexor muscle activation during push-off in late stance contributes importantly to reduced gait ability in adults with cerebral palsy (CP). Here we used low-intensity transcranial magnetic stimulation (TMS) to suppress soleus EMG activity during push-off as an estimate of corticospinal drive in CP adu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05520-3
更新日期：2019-06-01 00:00:00
abstract：:A afferent fibers have been reported to participate in the development of the central sensitization induced by inflammation and injuries. Current evidence suggests that myofascial trigger points (MTrPs) induce central sensitization in the related spinal dorsal horn, and clinical studies indicate that A fibers are asso...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4382-x
更新日期：2015-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4340-7
更新日期：2015-09-01 00:00:00
abstract：:Motoneurones innervating the retractor bulbi muscle in the cat have been identified by retrograde labelling with horseradish peroxidase, by intracellular recording and by intracellular staining with horseradish peroxidase. Their somata are found in an accessory abducens nucleus, analogous to that described in some oth...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239148
更新日期：1979-02-15 00:00:00
