Abstract：
:Cortical migration defects are often associated with epilepsy. In mesial temporal lobe epilepsy (MTLE), granule cell dispersion (GCD), a migration defect of dentate granule cells, is frequently observed. Little is known how GCD develops and to which extent it contributes to the development of seizure activity. Since the reelin-deficient reeler mouse mutant shows a similar migration defect of dentate cells, we performed a series of studies investigating whether reelin deficiency is involved in GCD development. We show that in MTLE patients and in a mouse model of MTLE, the development of GCD correlates with a loss of the extracellular matrix protein reelin. In addition, we present evidence that GCD occurs in the absence of neurogenesis, thus representing a displacement of mature neurons due to a reelin deficiency. Accordingly, antibody blockade of reelin function in naïve, adult mice induced GCD. Finally, we show that GCD formation can be prevented by infusion of exogenous reelin. In summary, these studies show that in epilepsy reelin dysfunction causes GCD development and that reelin is important for the maintenance of layered structures in the adult brain.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Haas CA,Frotscher Mdoi
10.1007/s00221-009-1948-5subject
Has Abstractpub_date
2010-01-01 00:00:00pages
141-9issue
2eissn
0014-4819issn
1432-1106journal_volume
200pub_type
杂志文章,评审abstract：:Is it possible to learn to perform a motor sequence without awareness of the sequence? In two experiments, we presented participants with the most elementary sequence: an alternation between two options. We used a double-step pointing task in which the final position of the target alternated between two quite similar ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4566-z
更新日期：2016-06-01 00:00:00
abstract：:In earlier studies the tetrahydroisoquinoline derivative N-methyl-norsalsolinol (2-MDTIQ) was discovered in lumbar cerebrospinal fluid and brain of patients with Parkinson's disease. To establish whether 2-MDTIQ is toxic to the dopaminergic system, 2-MDTIQ or 6-hydroxydopamine (6-OHDA) were stereotactically injected i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227181
更新日期：1996-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1294-3
更新日期：2003-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00249904
更新日期：1989-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-4898-3
更新日期：2017-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5201-y
更新日期：2018-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3572-7
更新日期：2013-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239400
更新日期：1983-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000627
更新日期：2001-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2107-8
更新日期：2010-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002210000673
更新日期：2001-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3693-z
更新日期：2013-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05747-5
更新日期：2020-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-019-05721-w
更新日期：2020-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1449-y
更新日期：2008-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250579
更新日期：1989-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05856-1
更新日期：2020-09-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2181-x
更新日期：2005-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005691
更新日期：1997-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2089-6
更新日期：2010-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-2288-8
更新日期：2005-08-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0761-7
更新日期：2007-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2126-5
更新日期：2010-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229783
更新日期：1993-01-01 00:00:00
abstract：:Several non-physiological stimuli (i.e. pharmacological or electrical stimuli) have been shown to induce Fos expression in striatal neurons. In this work, striatal Fos (i.e. Fos-like) expression was studied after physiological stimulation, i.e. motor activity (treadmill running at 36 m/min for 20 min). In rats killed ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005715
更新日期：1997-07-01 00:00:00
abstract：:The preceding study of the influence of various stimulus parameters on a single subject's pattern-on-set visual evoked potentials (VEPs) identified several constituent potentials with distinctive stimulus-related (and topographic) response properties. This paper describes related experiments in which an appropriate se...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00229559
更新日期：1996-09-01 00:00:00
abstract：:The effects of left and right alignment on the Ebbinghaus illusion were investigated in three experiments. In Experiment 1, the Ebbinghaus illusion was presented on the left or right side, and the points of subjective equality (PSE) were measured. Only the central disk of the figure with small inducers was perceived l...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5168-8
更新日期：2018-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0653-x
更新日期：2007-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247597
更新日期：1988-01-01 00:00:00
abstract：:It is generally accepted that transferrin receptor is located in the endothelial cells of the brain, but its existence in other brain cell types is less established. In this study, a [(125)I]transferrin binding assay was used to determine whether there is transferrin receptor on the membrane of cultured rat cortical a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050916
更新日期：1999-12-01 00:00:00
