Effects of yeast-derived beta-glucans on blood cholesterol and macrophage functionality.

abstract：:The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...

journal_title：Journal of immunotoxicology

authors： Galbiati V,Mitjans M,Corsini E

更新日期：2010-10-01 00:00:00

abstract：:The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

journal_title：Journal of immunotoxicology

authors： Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

更新日期：2020-12-01 00:00:00

abstract：:Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...

journal_title：Journal of immunotoxicology

authors： Antoine F,Girard D

更新日期：2015-04-01 00:00:00

abstract：:The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent respons...

journal_title：Journal of immunotoxicology

authors： Kwast L,Fiechter D,Kruijssen L,Bleumink R,Ludwig I,Bol-Schoenmakers M,Smit J,Pieters R

更新日期：2016-07-01 00:00:00

abstract：:The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Whereas a positive association between p,p'-DDE, a DDT metabolite, and Type...

journal_title：Journal of immunotoxicology

authors： Cetkovic-Cvrlje M,Olson M,Schindler B,Gong HK

更新日期：2016-01-01 00:00:00

abstract：:Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...

journal_title：Journal of immunotoxicology

authors： Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel R

更新日期：2012-10-01 00:00:00

abstract：:Cardiac allografts induce host immune responses that lead to endomyocardial tissue injury and progressive graft dysfunction. Inflammatory cell infiltration and myocyte damage characterize acute cellular rejection (ACR) that presents episodically in either a subclinical or symptom-associated manner. Sampling of the end...

journal_title：Journal of immunotoxicology

authors： Fang KC

更新日期：2007-07-01 00:00:00

abstract：:In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...

journal_title：Journal of immunotoxicology

authors： Lee HS,Cho DW,Han JS,Han SC,Woo SK,Jun SY,Lee WJ,Yoon S,Pak SI,Lee SJ,Seong E,Park EJ

更新日期：2020-12-01 00:00:00

abstract：:First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...

journal_title：Journal of immunotoxicology

authors： Cohen MD,Vaughan JM,Garrett B,Prophete C,Horton L,Sisco M,Kodavanti UP,Ward WO,Peltier RE,Zelikoff J,Chen LC

更新日期：2015-04-01 00:00:00

abstract：:Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...

journal_title：Journal of immunotoxicology

authors： Rodriguez-Lara V,Muñiz-Rivera Cambas A,González Villalva A,Fortoul TI

更新日期：2016-07-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...

journal_title：Journal of immunotoxicology

authors： Leung-Gurung L,Escalante Cobb P,Mourad F,Zambrano C,Muscato Z,Sanchez V,Godde K,Broussard C

更新日期：2018-12-01 00:00:00

abstract：:Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...

journal_title：Journal of immunotoxicology

authors： Springs AE,Rice CD

更新日期：2006-01-01 00:00:00

abstract：:Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...

journal_title：Journal of immunotoxicology

authors： Wang H,Zhang JX,Ye LP,Li SL,Wang F,Zha WS,Shen T,Wu C,Zhu QX

更新日期：2016-07-01 00:00:00

abstract：:Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-specific IgE antibody in a clinical study. Female, atopic subjects (n ...

journal_title：Journal of immunotoxicology

authors： Sarlo K,Adamson GM,Hollis VL,Innis JD,Babcock LS,Kirchner DB

更新日期：2004-04-01 00:00:00

abstract：:As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...

journal_title：Journal of immunotoxicology

authors： Zhang YH,Wang J,Dong GH,Liu MM,Wang D,Zheng L,Jin YH

更新日期：2013-01-01 00:00:00

abstract：:Vanadium, an important air pollutant derived from fuel product combustion, aggravates respiratory diseases and impairs cardiovascular function. In contrast, its effects on immune response are conflicting. The aim of our work was to determine if spleens of vanadium-exposed CD1 mice showed histological lesions that migh...

journal_title：Journal of immunotoxicology

authors： Pinon-Zarate G,Rodriguez-Lara V,Rojas-Lemus M,Martinez-Pedraza M,Gonzalez-Villalva A,Mussali-Galante P,Fortoul TI,Barquet A,Masso F,Montano LF

更新日期：2008-04-01 00:00:00

abstract：:Workers exposed to benzene frequently suffer from toxicities of the bone marrow as well as the central nervous, immune, and reproductive systems. This toxicity most likely is a result of the oxidative metabolism of benzene to reactive products. As green tea possesses antioxidant effects, the objective of this study wa...

journal_title：Journal of immunotoxicology

authors： Emara AM,El-Bahrawy H

更新日期：2008-01-01 00:00:00

abstract：:Here we sought to determine whether prenatal exposure to subtoxic levels of inorganic mercury induced modulations in the fetal immune repertoire. After overnight breeding of female BALB/c and male DBA/1 mice, pregnant females were exposed to 10 mg/l mercuric chloride in drinking water. DBF(1) pups were examined at day...

journal_title：Journal of immunotoxicology

authors： Pilones K,Lai ZW,Gavalchin J

更新日期：2007-10-01 00:00:00

abstract：:Exposure to subacute ozone (O3) causes pulmonary neutrophil recruitment. In mice, this recruitment requires IL-17A. Ozone also causes expression of IL-23 and IL-1, which can induce IL-17A. The purpose of this study was to examine the hypothesis that IL-23 and IL-1 contribute to IL-17A expression and subsequent neutrop...

journal_title：Journal of immunotoxicology

authors： Brand JD,Mathews JA,Kasahara DI,Wurmbrand AP,Shore SA

更新日期：2016-05-01 00:00:00

abstract：:The intestinal environment is considered to play an important role both in colorectal tumor development and in the evolution and modulation of mucosal immunity. Studies in animals reared in germ-free (GF, without any intestinal microflora) versus conventional (CV, with regular microflora in bowel) conditions can aid i...

journal_title：Journal of immunotoxicology

authors： Vannucci L,Stepankova R,Grobarova V,Kozakova H,Rossmann P,Klimesova K,Benson V,Sima P,Fiserova A,Tlaskalova-Hogenova H

更新日期：2009-12-01 00:00:00

abstract：:Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...

journal_title：Journal of immunotoxicology

authors： Quinn MJ Jr,McFarland CA,LaFiandra EM,Johnson MS

更新日期：2009-09-01 00:00:00

abstract：:Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...

journal_title：Journal of immunotoxicology

authors： Peillex C,Pelletier M

更新日期：2020-12-01 00:00:00

abstract：:The concept of immunological surveillance implies that immunogenic variants of tumor cells arising in the organism can be recognized by the immune system. Tumor progression is provided by somatic evolution of tumor cells under the pressure of the immune system. The loss of MHC Class I molecules on the surface of tumor...

journal_title：Journal of immunotoxicology

authors： Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB

更新日期：2014-10-01 00:00:00

abstract：:In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...

journal_title：Journal of immunotoxicology

authors： Kimber I,Pieters R

更新日期：2013-04-01 00:00:00

abstract：:In recent years, progress has been made in understanding how peptides presented by MHC Class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and various types of tumor cells. Th...

journal_title：Journal of immunotoxicology

authors： Seliger B

更新日期：2008-10-01 00:00:00

abstract：:In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...

journal_title：Journal of immunotoxicology

authors： Mandarapu R,Prakhya BM

更新日期：2015-01-01 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...

journal_title：Journal of immunotoxicology

authors： Dahlén E,Barchan K,Herrlander D,Höjman P,Karlsson M,Ljung L,Andersson M,Bäckman E,Hager AC,Walse B,Joosten L,van den Berg W

更新日期：2008-04-01 00:00:00

abstract：:Malignant melanoma is a very representative disease in terms of tumor progression processes. During its evolution, a series of events takes place; among these, the cells' 'out-of-control' growth and loss of homeostasis play crucial roles in the genesis of the tumor itself and its subsequent progression. These events i...

journal_title：Journal of immunotoxicology

authors： Botti G,Cerrone M,Scognamiglio G,Anniciello A,Ascierto PA,Cantile M

更新日期：2013-07-01 00:00:00

abstract：:Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

journal_title：Journal of immunotoxicology

authors： Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

更新日期：2012-01-01 00:00:00

abstract：:Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induce...

journal_title：Journal of immunotoxicology

authors： Peña C,Hernández-Fonseca JP,Pedreañez A,Viera N,Mosquera J

更新日期：2016-05-01 00:00:00