Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection.

abstract：BACKGROUND:RNA-seq and small RNA-seq are powerful, quantitative tools to study gene regulation and function. Common high-throughput sequencing methods rely on polymerase chain reaction (PCR) to expand the starting material, but not every molecule amplifies equally, causing some to be overrepresented. Unique molecular i...

journal_title：BMC genomics

authors： Fu Y,Wu PH,Beane T,Zamore PD,Weng Z

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Cryptic unstable transcripts (CUTs) are a largely unexplored class of nuclear exosome degraded, non-coding RNAs in budding yeast. It is highly debated whether CUT transcription has a functional role in the cell or whether CUTs represent noise in the yeast transcriptome. We sought to ascertain the extent of c...

journal_title：BMC genomics

authors： Vera JM,Dowell RD

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However, there is no information about the changes produced by the wounds...

journal_title：BMC genomics

authors： Cordero H,Brinchmann MF,Cuesta A,Esteban MA

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:Bacterial non-coding RNAs act by base-pairing as regulatory elements in crucial biological processes. We performed the identification of trans-encoded small RNAs (sRNA) from the genomes of Mycoplama hyopneumoniae, Mycoplasma flocculare and Mycoplasma hyorhinis, which are Mycoplasma species that have been ide...

journal_title：BMC genomics

authors： Siqueira FM,de Morais GL,Higashi S,Beier LS,Breyer GM,de Sá Godinho CP,Sagot MF,Schrank IS,Zaha A,de Vasconcelos AT

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:High-throughput omics technologies such as microarrays and next-generation sequencing (NGS) have become indispensable tools in biological research. Computational analysis and biological interpretation of omics data can pose significant challenges due to a number of factors, in particular the systems integrat...

journal_title：BMC genomics

authors： Hermida L,Poussin C,Stadler MB,Gubian S,Sewer A,Gaidatzis D,Hotz HR,Martin F,Belcastro V,Cano S,Peitsch MC,Hoeng J

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:Major changes in gene expression occur in the fetal brain to modulate the function of this organ postnatally. Thus, factors can alter the genomics of the fetal brain, predisposing to neurological disorders later in life. We hypothesized that the physiological dynamics of the immune system transcriptome of th...

journal_title：BMC genomics

authors： Rabaglino MB,Keller-Wood M,Wood CE

更新日期：2014-11-19 00:00:00

abstract：BACKGROUND:The term pan-genome was proposed to denominate collections of genomic sequences jointly analyzed or used as a reference. The constant growth of genomic data intensifies development of data structures and algorithms to investigate pan-genomes efficiently. RESULTS:This work focuses on providing a tool for dis...

journal_title：BMC genomics

authors： Dziadkiewicz P,Dojer N

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Aeromonas salmonicida subsp. salmonicida is a ubiquitous psychrophilic waterborne bacterium and a fish pathogen. The numerous mobile elements, especially insertion sequences (IS), in its genome promote rearrangements that impact its phenotype. One of the main virulence factors of this bacterium, its type thr...

journal_title：BMC genomics

authors： Tanaka KH,Vincent AT,Emond-Rheault JG,Adamczuk M,Frenette M,Charette SJ

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:The process of alternative splicing provides a unique mechanism by which eukaryotes are able to produce numerous protein products from the same gene. Heightened variability in the proteome has been thought to potentiate increased behavioral complexity and response flexibility to environmental stimuli, thus c...

journal_title：BMC genomics

authors： Lang AS,Austin SH,Harris RM,Calisi RM,MacManes MD

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Cowpea, Vigna unguiculata (L.) Walp., is one of the most important food and forage legumes in the semi-arid tropics because of its drought tolerance and ability to grow on poor quality soils. Approximately 80% of cowpea production takes place in the dry savannahs of tropical West and Central Africa, mostly b...

journal_title：BMC genomics

authors： Timko MP,Rushton PJ,Laudeman TW,Bokowiec MT,Chipumuro E,Cheung F,Town CD,Chen X

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors upon radiotherapy decrease according to the sizes of tumors and RT models based on Poisson statistics ...

journal_title：BMC genomics

authors： Yang JY,Niemierko A,Yang MQ,Deng Y

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Aspergillus arachidicola is an aflatoxigenic fungal species, first isolated from the leaves of a wild peanut species native to Argentina. It has since been reported in maize, Brazil nut and human sputum samples. This aflatoxigenic species is capable of secreting both B and G aflatoxins, similar to A. parasit...

journal_title：BMC genomics

authors： Moore GG,Mack BM,Beltz SB,Puel O

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Laminitis, the structural failure of interdigitated tissue that suspends the distal skeleton within the hoof capsule, is a devastating disease that is the second leading cause of both lameness and euthanasia in the horse. Current transcriptomic research focuses on the expression of known genes. However, as t...

journal_title：BMC genomics

authors： Holl HM,Gao S,Fei Z,Andrews C,Brooks SA

更新日期：2015-10-03 00:00:00

abstract：BACKGROUND:Pharmacological and gene ablation studies have demonstrated the crucial role of the endocrine function of the heart as mediated by the polypeptide hormones ANF and BNP in the maintenance of cardiovascular homeostasis. The importance of these studies lies on the fact that hypertension and chronic congestive h...

journal_title：BMC genomics

authors： McGrath MF,de Bold AJ

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Microsatellites are extremely common in plant genomes, and in particular, they are significantly enriched in the 5' noncoding regions. Although some 5' noncoding microsatellites involved in gene regulation have been described, the general properties of microsatellites as regulatory elements are still unknown...

journal_title：BMC genomics

authors： Zhang L,Zuo K,Zhang F,Cao Y,Wang J,Zhang Y,Sun X,Tang K

更新日期：2006-12-25 00:00:00

abstract：BACKGROUND:While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus performed full genome analyses on four Listeria monocytogenes, including human and food isolates from both a 1988 case of sporadic...

journal_title：BMC genomics

authors： Orsi RH,Borowsky ML,Lauer P,Young SK,Nusbaum C,Galagan JE,Birren BW,Ivy RA,Sun Q,Graves LM,Swaminathan B,Wiedmann M

更新日期：2008-11-13 00:00:00

abstract：BACKGROUND:Chlamydomonas reinhardtii is the model organism that serves as a reference for studies in algal genomics and physiology. It is of special interest in the study of the evolution of regulatory pathways from algae to higher plants. Additionally, it has recently gained attention as a potential source for bio-fue...

journal_title：BMC genomics

authors： Romero-Campero FJ,Perez-Hurtado I,Lucas-Reina E,Romero JM,Valverde F

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla) is a seed-borne fungus causing Phomopsis seed decay in soybean. This disease is one of the most devastating diseases reducing soybean seed quality worldwide. To facilitate investigation of the genomic basis of pathogenicity and to understand the me...

journal_title：BMC genomics

authors： Li S,Darwish O,Alkharouf NW,Musungu B,Matthews BF

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Inadvertent sample swaps are a real threat to data quality in any medium to large scale omics studies. While matches between samples from the same individual can in principle be identified from a few well characterized single nucleotide polymorphisms (SNPs), omics data types often only provide low to moderat...

journal_title：BMC genomics

authors： Westphal M,Frankhouser D,Sonzone C,Shields PG,Yan P,Bundschuh R

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The sustainability of poultry farming relies on the development of more efficient and autonomous production systems in terms of feed supply. This implies a better integration of adaptive traits in breeding programs, including digestive efficiency, in order to favor the use of a wider variety of feedstuffs. T...

journal_title：BMC genomics

authors： Juanchich A,Hennequet-Antier C,Cabau C,Le Bihan-Duval E,Duclos MJ,Mignon-Grasteau S,Narcy A

更新日期：2018-12-13 00:00:00

abstract：BACKGROUND:With the development of several new technologies using synthetic biology, it is possible to engineer genetically intractable organisms including Mycoplasma mycoides subspecies capri (Mmc), by cloning the intact bacterial genome in yeast, using the host yeast's genetic tools to modify the cloned genome, and s...

journal_title：BMC genomics

authors： Chandran S,Noskov VN,Segall-Shapiro TH,Ma L,Whiteis C,Lartigue C,Jores J,Vashee S,Chuang RY

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Analysis of single nucleotide polymorphisms (SNPs) derived from whole-genome studies allows for rapid evaluation of genome-wide diversity, and genomic epidemiology studies of Plasmodium falciparum provide insights into parasite population structure, gene flow, drug resistance and vaccine development. In area...

journal_title：BMC genomics

authors： Jacob CG,Tan JC,Miller BA,Tan A,Takala-Harrison S,Ferdig MT,Plowe CV

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:Ubiquitination is an important post-translational modification involved in diverse biological processes. Therefore, genomewide representation of the ubiquitination system for a species is important. DESCRIPTION:SCUD is a web-based database for the ubiquitination system in Saccharomyces cerevisiae (Baker's y...

journal_title：BMC genomics

authors： Lee WC,Lee M,Jung JW,Kim KP,Kim D

更新日期：2008-09-24 00:00:00

abstract：BACKGROUND:The European spruce bark beetle, Ips typographus, and the North American mountain pine beetle, Dendroctonus ponderosae (Coleoptera: Curculionidae: Scolytinae), are severe pests of coniferous forests. Both bark beetle species utilize aggregation pheromones to coordinate mass-attacks on host trees, while odora...

journal_title：BMC genomics

authors： Andersson MN,Grosse-Wilde E,Keeling CI,Bengtsson JM,Yuen MM,Li M,Hillbur Y,Bohlmann J,Hansson BS,Schlyter F

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:Despite the importance of wheat as a major staple crop and the negative impact of diseases on its production worldwide, the genetic mechanisms and gene interactions involved in the resistance response in wheat are still poorly understood. The complete sequence of the rice genome has provided an extremely use...

journal_title：BMC genomics

authors： Cantu D,Yang B,Ruan R,Li K,Menzo V,Fu D,Chern M,Ronald PC,Dubcovsky J

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Fistular leaves frequently appear in Allium species, and previous developmental studies have proposed that the process of fistular leaf formation involves programmed cell death. However, molecular evidence for the role of programmed cell death in the formation of fistular leaf cavities has yet to be reported...

journal_title：BMC genomics

authors： Zhu S,Tang S,Tan Z,Yu Y,Dai Q,Liu T

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Porcine circovirus type 2 (PCV2) is the causal agent of postweaning multisystemic wasting syndrome (PMWS), which has severely impacted the swine industry worldwide. PCV2 triggers a weak and atypical innate immune response, but the key genes and mechanisms by which the virus interferes with host innate immuni...

journal_title：BMC genomics

authors： Li W,Liu S,Wang Y,Deng F,Yan W,Yang K,Chen H,He Q,Charreyre C,Audoneet JC

更新日期：2013-05-27 00:00:00

abstract：BACKGROUND:Natural contamination and anthropogenic pollution of soils are likely to be major determinants of functioning and survival of keystone invertebrate taxa. Soil animals will have both evolutionary adaptation and genetically programmed responses to these toxic chemicals, but mechanistic understanding of such is...

journal_title：BMC genomics

authors： Owen J,Hedley BA,Svendsen C,Wren J,Jonker MJ,Hankard PK,Lister LJ,Stürzenbaum SR,Morgan AJ,Spurgeon DJ,Blaxter ML,Kille P

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Paenibacillus larvae is a Firmicute bacterium that causes American Foulbrood, a lethal disease in honeybees and is a major source of global agricultural losses. Although P. larvae phages were isolated prior to 2013, no full genome sequences of P. larvae bacteriophages were published or analyzed. This report ...

journal_title：BMC genomics

authors： Merrill BD,Grose JH,Breakwell DP,Burnett SH

更新日期：2014-08-30 00:00:00

abstract：BACKGROUND:BAC-based physical maps provide for sequencing across an entire genome or a selected sub-genomic region of biological interest. Such a region can be approached with next-generation whole-genome sequencing and assembly as if it were an independent small genome. Using the minimum tiling path as a guide, specif...

journal_title：BMC genomics

authors： Feltus FA,Saski CA,Mockaitis K,Haiminen N,Parida L,Smith Z,Ford J,Staton ME,Ficklin SP,Blackmon BP,Cheng CH,Schnell RJ,Kuhn DN,Motamayor JC

更新日期：2011-07-27 00:00:00