A perspective on clinical research strategies in carcinoma of the large bowel.

Abstract:

:Experience with screening for colorectal cancer has been disappointing. Prevention of this disease seems to be a more beneficial research direction. Although radical surgery presents the best treatment option, it is nonetheless an inadequate strategy by itself. A new dose intensive approach would temporally combine surgery and chemotherapy as a coordinated event. This would allow maximal cytoreduction over a minimal time period and little or no development of resistant cancer cells. This approach has resulted in a 75% projected 5 year survival in patients with peritoneal carcinomatosis from cystadenocarcinoma. Strategies for application of this cytoreductive approach in many patients with advanced gastrointestinal cancer are present.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Sugarbaker PH

doi

10.1007/BF01789207

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

609-16

issue

5

eissn

0364-2313

issn

1432-2323

journal_volume

15

pub_type

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