Abstract:
:The incidence of cardiovascular disease is low in healthy premenopausal women and increases with age especially after the menopause; this difference has been attributed to the loss of endogenous estrogen. Atherosclerosis is a chronic inflammatory condition of the vascular wall that may result in an acute clinical event by inducing plaque rupture/erosion leading to thrombosis. A growing body of evidence suggests that the spectrum of the effects of estrogen on vascular pathophysiology is complex and may depend largely on the state of vascular pathology. In relatively healthy vessels, estrogen prevents the development and progression of atherosclerotic lesions, while in the presence of established atherosclerotic plaques, estrogen fails to inhibit the progression of atherosclerosis or may even trigger cardiovascular events. The mechanisms responsible for this are not yet fully elucidated. It is possible that postmenopausal estrogen/progestogen therapy may be beneficial in perimenopausal and early menopausal women prior to atherosclerotic plaque formation, but it may not prevent progression of atherosclerotic plaques and acute cardiovascular events in older women with cardiovascular risk factors or women with established atherosclerosis. Various formulations, doses and routes of hormone therapy administration as well as the genetic background of women should also be taken into account when considering the benefit-to-risk ratio of hormone therapy use.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Bechlioulis A,Naka KK,Calis KA,Makrigiannakis A,Michalis L,Kalantaridou SNdoi
10.2174/157016110790886974subject
Has Abstractpub_date
2010-03-01 00:00:00pages
249-58issue
2eissn
1570-1611issn
1875-6212pii
CVP-Abs-029journal_volume
8pub_type
杂志文章,评审abstract::Chronic venous disease (CVeD) is a debilitating condition that affects millions of individuals worldwide. The condition can result in varicose veins, or advance to severe skin changes and venous ulceration. The fundamental basis for CVeD is inflammation within the venous circulation and that it is subjected to increas...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161111666131126144025
更新日期:2014-01-01 00:00:00
abstract::The "pleiotropic" effects of statins have been the centre of a considerable research activity. Among the numerous experimental and clinical studies of this field, some focused on the effects of statins on blood pressure (BP), while others reported data on BP together with other parameters. Some of the animal or human ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016107780368307
更新日期:2007-04-01 00:00:00
abstract::In patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), 25OH-vitamin D (calcidiol) deficiency or insufficiency is a common finding with high prevalence. Numerous epidemiological studies have found an independent association of low levels of calcidiol with increased morbidity and mortality. Wi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/15701611113119990027
更新日期:2014-03-01 00:00:00
abstract::We evaluated the effects of the glycosaminoglycan sulodexide (SDX; antithrombotic/profibrinolytic drug) on the activity and release of matrix metalloproteinases (MMPs) in human blood. This was a prospective non-randomized study, analyzing by zymography and ELISA the in vitro effects of SDX on pro-enzyme, complexed, an...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161111311030010
更新日期:2013-05-01 00:00:00
abstract::Central arterial systolic blood pressure is a very important factor in the pathophysiology of cardiovascular diseases. Central arterial pressure is a better predictor of cardiovascular risk than peripheral brachial blood pressure. Measurement of central blood pressure is useful for a diagnosis of spurious systolic hyp...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110793563852
更新日期:2010-11-01 00:00:00
abstract::Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variatio...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111796197233
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment. METHODS:Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/1570161112666141014151858
更新日期:2015-01-01 00:00:00
abstract::Aspirin plays a pivotal role in the management of patients with Coronary Artery Disease (CAD) with well-recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing Percutaneous Coronary Intervention (PCI). Dual antiplatelet therapy is mandated for pa...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180604100220
更新日期:2019-01-01 00:00:00
abstract::Oxidative stress has been linked to the origin and progression of cardiovascular diseases. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase is a multi-component, NADPH-dependent enzyme that generates superoxide anion in the presence of molecular oxygen. The enzyme has been identified and chara...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016108784911984
更新日期:2008-07-01 00:00:00
abstract::Cardiovascular disease (CVD) is among the most major causes of morbidity and mortality worldwide. Great progress has been made in the management of CVD which has been influenced by the use of experimental animal models. These models provided information at cellular and molecular levels and allowed the development of t...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161113666150212151506
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), are major health problems worldwide. Genetics may play a role in the pathogenesis of NAFLD/NASH. AIM:To investigate the prevalence of NAFLD/NASH in 5,400 military personnel and evaluate the effect of treatme...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666201015152921
更新日期:2020-10-15 00:00:00
abstract::It is well known that solid cancers are associated with thromboembolic complications, but recent studies have shown that the incidence of thrombosis may be as high (or even higher) in patients with malignant haematological disorders. However, this may be obscured by the significant morbidity and mortality due to other...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110791330799
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Obstructive Sleep Apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal Blood Pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causativ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170414115705
更新日期:2017-01-01 00:00:00
abstract::Obstructive sleep apnoea (OSA) is characterized by repetitive interruptions of breathing, causing Chronic Intermittent Hypoxia (CIH) that can be involved in the development and progression of cardiovascular diseases. There is evidence showing a close relationship between OSA and atherosclerosis, even in patients who d...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161114666161007164112
更新日期:2017-01-01 00:00:00
abstract::A number of epidemiological studies have shown that diets rich in plant-derived phenolic compounds reduce the risk of coronary heart disease. The chronic antioxidant and hypolipidemic activities of these compounds have important roles in prevention of lipoprotein oxidation and atherosclerotic lesion development. In re...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161033476736
更新日期:2003-06-01 00:00:00
abstract::Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people with diabetes mellitus, and are major risk factors for foot ulceration, amputation and cardiovascular dysfunction. Peripheral neuropathies manifest with either painful or painless symptoms, but many patients experience both. O...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190521101342
更新日期:2020-01-01 00:00:00
abstract::The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized from the amino acid L-arginine in endothelial cells by the constitutive calcium-calmodulin-dependent enzyme nitric oxide synthase (NOS). This subst...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112798829760
更新日期:2012-01-01 00:00:00
abstract::There is growing evidence that Rho-kinase contributes to cardiovascular disease, which has made Rho-kinase a target for the treatment of human diseases. To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161112666140613115813
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Volatile Anaesthetics (VA) are commonly used worldwide for induction and/or maintenance of general anaesthesia. They act in the central nervous system to reduce sensation and motor response during surgical and invasive diagnostic procedures. VAs also have some non-anaesthetic properties in the brain when adm...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666171013153750
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Chlamydia pneumoniae was the first pathogen linked with carotid atherosclerotic changes and plaque rupture. Currently, other common pathogens are also under investigation as potential contributors. METHODS:A systematic review of PubMed and Scopus databases was performed. Studies evaluating the infectious ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110793563889
更新日期:2010-11-01 00:00:00
abstract:: ...
journal_title:Current vascular pharmacology
pub_type: 社论
doi:10.2174/1570161116666180713120217
更新日期:2019-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161111311050013
更新日期:2013-09-01 00:00:00
abstract::Post-transplant diabetes mellitus (PTDM) and dyslipidaemia are the most common metabolic complications in kidney transplant recipients (KTR). They are associated with a higher risk of lower graft function and survival, as well as an increased risk of cardiovascular disease (CVD). The aim of this review is to provide c...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190619143005
更新日期:2020-01-01 00:00:00
abstract::Revascularization procedures used for the treatment of cardiovascular disease can be associated with restenosis, although drug-coated stents have greatly reduced this complication. Both type 2 diabetes (T2DM) and metabolic syndrome (MetS) are associated with a high risk for atherosclerosis and restenosis. Insulin resi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111795495558
更新日期:2011-05-01 00:00:00
abstract::This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanis...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666181031143628
更新日期:2019-01-01 00:00:00
abstract::The hypothesis of 'Developmental Origins of Health and Disease' (DOHaD) relies on the presence of mechanisms sensing and signalling a diversity of stimuli during fetal development. The mechanisms that have been broadly suggested to be involved in these processes are the epigenetic modifications that could 'record' per...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016109789043883
更新日期:2009-10-01 00:00:00
abstract::Loss of normal endothelial function and bioactivity of nitric oxide (NO), associated with increased production of reactive oxygen species (ROS), are characteristics of cardiovascular disease states. There is good experimental evidence that these abnormalities are causally related to cardiovascular disease pathogeneses...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112803520819
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of s...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016108785909797
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. OBJECTIVE:To investigate whether t...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161115666170609102506
更新日期:2018-01-01 00:00:00
abstract::In this issue of Curr Vasc Pharmacol, Pfeiffer et al. [1] and Glorioso et al. [2] report the efficacy and tolerability of aliskiren/amlodipine single-pill combinations (SPCs) in patients with inadequate blood pressure (BP) response to amlodipine or aliskiren monotherapy, respectively. ...
journal_title:Current vascular pharmacology
pub_type: 评论,社论
doi:10.2174/157016112803520783
更新日期:2012-11-01 00:00:00