Neuropeptides regulate expression of angiogenic growth factors in human dental pulp fibroblasts.

Abstract:

INTRODUCTION:Neuropeptides play an important role in inflammation and repair and have been implicated in mediating angiogenesis. Pulp fibroblasts express neuropeptide receptors, and the aim of this research was to investigate whether neuropeptides could regulate angiogenic growth factor expression in vitro METHODS:An angiogenic array was used to determine the levels of 10 angiogenic growth factors expressed by human pulp fibroblasts. RESULTS:Pulp fibroblasts were shown to express angiogenin, angiopoietin-2, epidermal growth factor, basic fibroblast growth factor, heparin-binding epidermal growth factor, hepatocyte growth factor, leptin, platelet-derived growth factor, placental growth factor, and vascular endothelial growth factor. Furthermore, the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and neuropeptide Y altered angiogenic growth factor expression in vitro. CONCLUSIONS:The regulation of angiogenic growth factor expression by neuropeptides suggests a novel role for neuropeptides in pulpal inflammation and repair.

journal_name

J Endod

journal_title

Journal of endodontics

authors

El Karim IA,Linden GJ,Irwin CR,Lundy FT

doi

10.1016/j.joen.2009.03.005

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

829-33

issue

6

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(09)00177-0

journal_volume

35

pub_type

杂志文章
  • Endodontic retreatment of thermafil or lateral condensation obturations in post space prepared teeth.

    abstract::The purpose of this study was to quantify the amount of remaining gutta-percha/sealer after retreatment of post space prepared teeth obturated with a lateral condensation technique or with Thermafil with plastic and metallic carrier. The time required for retreatment was also recorded. Forty-five extracted mandibular ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/s0099-2399(06)80019-1

    authors: Zuolo ML,Imura N,Ferreira MO

    更新日期:1994-01-01 00:00:00

  • Expression and characterization of vanilloid receptor subtype 1 in human dental pulp cell cultures.

    abstract::The expression of the vanilloid receptor subtype 1 (VR1, TRPV1) was detected in human dental pulp fibroblasts (PF-10) using RT-PCR, Western blotting, and immunocytochemical analysis. As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited ca...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1097/01.don.0000155259.22746.ae

    authors: Miyamoto R,Tokuda M,Sakuta T,Nagaoka S,Torii M

    更新日期:2005-09-01 00:00:00

  • The deterioration of rotary nickel-titanium files under controlled conditions.

    abstract::It has been shown that rotary nickel-titanium files cannot be used indefinitely. Researchers and clinicians have not been able to agree on how many times a file can be used before being discarded, except if a file has fractured or become visibly distorted. This study used ISO size 20 files of 0.04 taper in the curved ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1097/00004770-200202000-00014

    authors: Svec TA,Powers JM

    更新日期:2002-02-01 00:00:00

  • Effect of chlorhexidine and ethanol on the durability of the adhesion of the fiber post relined with resin composite to the root canal.

    abstract:INTRODUCTION:The aim of this study was to investigate the effects of pretreatment of gel chlorhexidine and ethanol on the bond strength and durability of the adhesion of the fiber post relined with resin composite to the root dentin. METHODS:Sixty bovine incisor roots were divided into four groups: irrigation with phy...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2011.01.007

    authors: Cecchin D,de Almeida JF,Gomes BP,Zaia AA,Ferraz CC

    更新日期:2011-05-01 00:00:00

  • Microbial leakage evaluation of the continuous wave of condensation.

    abstract::Coronal leakage has been recognized as a cause of pulpal and periradicular disease. Although cleaning and shaping of the root canal system is considered paramount, obturation of the system is an important step in endodontic success. The purpose of this study was to evaluate coronal bacterial leakage in teeth obturated...

    journal_title:Journal of endodontics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004770-200204000-00002

    authors: Jacobson HL,Xia T,Baumgartner JC,Marshall JG,Beeler WJ

    更新日期:2002-04-01 00:00:00

  • Effect of apical size and taper on volume of irrigant delivered at working length with apical negative pressure at different root curvatures.

    abstract:INTRODUCTION:The purpose of this investigation was to determine the effect that apical preparation size and preparation taper have on the volume of irrigant delivered at the working length for different canal curvatures using apical negative pressure irrigation. METHODS:One hundred fifty-five human teeth (55 maxillary...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.joen.2012.10.008

    authors: de Gregorio C,Arias A,Navarrete N,Del Rio V,Oltra E,Cohenca N

    更新日期:2013-01-01 00:00:00

  • Accuracy of High-resolution Small-volume Cone-Beam Computed Tomography in the Diagnosis of Vertical Root Fracture: An In Vivo Analysis.

    abstract:INTRODUCTION:The purpose of this in vivo study was to evaluate the accuracy of small-volume cone-beam computed tomographic (CBCT) imaging compared with conventional periapical radiography (CPR) in the diagnosis of vertical root fractures (VRFs) using exploratory surgery as the reference standard. METHODS:Eighty-two de...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2020.04.015

    authors: Dias DR,Iwaki LCV,de Oliveira ACA,Martinhão FS,Rossi RM,Araújo MG,Hayacibara RM

    更新日期:2020-08-01 00:00:00

  • Effect of Repairing Endodontic Access Cavities on Survival of Single Crowns and Retainer Restorations.

    abstract:INTRODUCTION:This retrospective study aimed to analyze the effect of repairing endodontic access cavities with composite on the survival of single crowns and retainer restorations of fixed or removable dental prostheses. METHODS:Dental records of patients attending a university dental clinic were retrospectively scree...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2019.11.012

    authors: Wiegand A,Kanzow P

    更新日期:2020-03-01 00:00:00

  • A dye penetration study of retrofilling materials.

    abstract::The apical sealing ability of amalgam, cold-burnished gutta-percha, amalgam with cavity varnish, and SuperEBA cement was evaluated in extracted human teeth. For each experimental group, the roots of 20 single-rooted teeth were sectioned from their crowns. Canals were cleaned, shaped, and obturated with vertically cond...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/S0099-2399(89)80132-3

    authors: Tuggle ST,Anderson RW,Pantera EA Jr,Neaverth EJ

    更新日期:1989-03-01 00:00:00

  • An immunohistological study on cyclooxygenase-2 in human dental pulp.

    abstract::Characteristics of cyclooxygenase-2 (COX-2) expressing cells in human dental pulp were immunohistologically studied. Extirpated pulpal tissues from extracted teeth were examined to elucidate the localization and distribution of COX-2. Pulpal tissues were examined by the labeled streptavidin biotin method using specifi...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1097/00004770-200106000-00003

    authors: Nakanishi T,Shimizu H,Hosokawa Y,Matsuo T

    更新日期:2001-06-01 00:00:00

  • Kinematics of 2 reciprocating endodontic motors: the difference between actual and set values.

    abstract:INTRODUCTION:The aim of this study was to evaluate the kinematics of 2 reciprocating motors and compare it with manufacturers' declared values. METHODS:VDW Silver (VDW, Munich, Germany) and ATR Tecnika (Tecnika, Pistoia, Italy) were used in the study in 5 working modes: continuous rotation at 400 rpm on VDW Silver and...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2013.12.008

    authors: Fidler A

    更新日期:2014-07-01 00:00:00

  • 2-Hydroxyethyl methacrylate inhibits migration of dental pulp stem cells.

    abstract:INTRODUCTION:Cell migration is an important step in pulpal wound healing. Although components in the resin-based dental materials are known to have adverse effects on pulp wound healing including proliferation and mineralization, their effects on cell migration have been scarcely examined. Here, we investigated the eff...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2013.06.004

    authors: Williams DW,Wu H,Oh JE,Fakhar C,Kang MK,Shin KH,Park NH,Kim RH

    更新日期:2013-09-01 00:00:00

  • Synergistic effect of microbubble emulsion and sonic or ultrasonic agitation on endodontic biofilm in vitro.

    abstract:INTRODUCTION:Irrigation dynamics and antibacterial activity determine the efficacy of root canal disinfection. Sonic or ultrasonic agitation of irrigants is expected to improve irrigation dynamics. This study examined the effects of microbubble emulsion (ME) combined with sonic or ultrasonic agitation on irrigation dyn...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2012.07.007

    authors: Halford A,Ohl CD,Azarpazhooh A,Basrani B,Friedman S,Kishen A

    更新日期:2012-11-01 00:00:00

  • Tumor Necrosis Factor Receptor-associated Factor 6 Plays a Role in the Inflammatory Responses of Human Periodontal Ligament Fibroblasts to Enterococcus faecalis.

    abstract:INTRODUCTION:Enterococcus faecalis is a frequently isolated microorganism in persistent periapical lesion or secondary infection. However, no evidence has demonstrated that E. faecalis induced inflammation directly in the apical area. This study aimed to explore the mechanism of the inflammatory responses of human peri...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2015.08.028

    authors: Zhang L,Wang T,Lu Y,Zheng Q,Gao Y,Zhou X,Huang D

    更新日期:2015-12-01 00:00:00

  • A clinical comparison of treatments for endemic dental fluorosis.

    abstract::A case report is presented describing the treatment for endemic dental fluorosis. Six maxillary anterior teeth were treated, three with an acid-bleach combination technique and three with an acid technique. No clinical differences was noted in treatment time or esthetic results. ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/S0099-2399(06)81703-6

    authors: Wong M

    更新日期:1991-07-01 00:00:00

  • Regional push-out bond strength and coronal microleakage of Resilon after different light-curing methods.

    abstract::The purpose of this study was to assess the push-out bond strength and coronal microleakage of the Epiphany (Pentron Clinical Technologies, Wallingford, CT) + Resilon (Resilon Research LLC, Madison, CT) obturation system with respect to different photoactivation methods used. Roots of human maxillary central incisors ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2007.07.028

    authors: Nagas E,Cehreli ZC,Durmaz V,Vallittu PK,Lassila LV

    更新日期:2007-12-01 00:00:00

  • Prevalence of Candida Species in Endodontic Infections: Systematic Review and Meta-analysis.

    abstract:INTRODUCTION:Candida in endodontic infections has been investigated in a large number of studies, but its role as an endodontic pathogen is still debatable. The aim of this study was to systematically review the literature on the prevalence of Candida species in root canal infections. METHODS:Extensive literature rese...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.joen.2018.07.016

    authors: Mergoni G,Percudani D,Lodi G,Bertani P,Manfredi M

    更新日期:2018-11-01 00:00:00

  • Kinematic Effects of Nickel-Titanium Instruments with Reciprocating or Continuous Rotation Motion: A Systematic Review of In Vitro Studies.

    abstract:INTRODUCTION:This review aimed to compare the kinematic effect of nickel-titanium instruments with reciprocating and continuous rotation motion for cyclic fatigue resistance, shaping ability, apical debris extrusion, and dentinal defects or cracks. METHOD:Articles were selected for inclusion in this review if they ful...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,评审

    doi:10.1016/j.joen.2016.04.002

    authors: Ahn SY,Kim HC,Kim E

    更新日期:2016-07-01 00:00:00

  • Comparison of push-out bond strengths of Resilon with three different sealers.

    abstract:INTRODUCTION:The purpose of this study was to evaluate the push-out bond strengths of different obturating materials. METHODS:Forty single-rooted human extracted teeth were used in this study. The teeth were instrumented and irrigated by using 5.25% NaOCl, 15% ethylenediaminetetraacetic acid, and sterile water. The te...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2009.10.026

    authors: Stiegemeier D,Baumgartner JC,Ferracane J

    更新日期:2010-02-01 00:00:00

  • Treatment of stripping perforations.

    abstract::Strippings are problems that are frequent on thin and concave roots. Treatment and prognosis differ from that of a lateral root perforation because of the size, oval shape, and thin edges of the striping. We propose a two-step technique: an endodontic phase in which the root canal system is sealed with gutta-percha ov...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/S0099-2399(96)80069-0

    authors: Allam CR

    更新日期:1996-12-01 00:00:00

  • Cutaneous sinus tract caused by vertical root fracture.

    abstract::This report presents a rare case of odontogenic cutaneous sinus tract caused by a vertical root fracture. The root-fractured molar was probably caused by an accidental blow by a cow 3 years ago. Despite all treatments by physicians and surgeons for nearly 1 year, the sinus tract recurred repeatedly. After diagnosis an...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,评审

    doi:10.1016/s0099-2399(06)81130-1

    authors: Chan CP,Chang SH,Huang CC,Wu SK,Huang SK

    更新日期:1997-09-01 00:00:00

  • Reversal of pulpal and soft tissue anesthesia by using phentolamine: a prospective randomized, single-blind study.

    abstract:INTRODUCTION:Phentolamine mesylate has been reported to be an effective local anesthetic reversal agent for soft tissue but has not been studied regarding reversal of pulpal anesthesia. The authors conducted a prospective randomized, single-blind study comparing the reversal of pulpal and soft tissue anesthesia when ph...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.joen.2012.12.024

    authors: Elmore S,Nusstein J,Drum M,Reader A,Beck M,Fowler S

    更新日期:2013-04-01 00:00:00

  • Cytotoxic effects of 10% citric acid and EDTA-T used as root canal irrigants: an in vitro analysis.

    abstract::EDTA-T and 10% citric acid used as root canal irrigants lead to more visible dentinal tubules than 5% sodium hypochlorite associated with 3% hydrogen peroxide. However, these cleansing agents must be compatible with apical periodontal tissue. We analyzed the cytotoxicity of 10% citric acid and EDTA-T in cultured fibro...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1097/00004770-200112000-00007

    authors: Sceiza MF,Daniel RL,Santos EM,Jaeger MM

    更新日期:2001-12-01 00:00:00

  • The effect of endodontic therapy on periapical exudate neutrophil elastase and prostaglandin-E2 levels.

    abstract::This study aimed to investigate periapical exudate neutrophil elastase (NE) and prostaglandin E2 (PGE2) levels and their relationships with clinical symptoms, and to determine the changes of their levels following first treatment visit. Periapical exudate samples were collected from the canals of 34 nonvital single-ro...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1097/01.don.0000158010.43884.59

    authors: Alptekin NO,Ari H,Haliloglu S,Alptekin T,Serpek B,Ataoglu T

    更新日期:2005-11-01 00:00:00

  • Extension of bactericidal effect of sodium hypochlorite into dentinal tubules.

    abstract:INTRODUCTION:The aim of this study was to determine the extent of disinfection mediated by 2 concentrations of sodium hypochlorite for bacteria-laden dentin wall of a root canal. METHODS:A dual-species film, Enterococcus faecalis and Porphyromonas gingivalis, was cultivated on root canal dentin for 7 days. The canal w...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2013.09.045

    authors: Wong DT,Cheung GS

    更新日期:2014-06-01 00:00:00

  • The incidence of mechanical allodynia in patients with irreversible pulpitis.

    abstract::The mechanisms of odontogenic pain are complex and incompletely understood. Cases of irreversible pulpitis are thought to represent a localized inflammatory response to bacterial challenge in dental pulp tissue. The presenting symptoms are classically defined by exaggerated painful episodes to thermal stimuli that may...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2007.01.023

    authors: Owatz CB,Khan AA,Schindler WG,Schwartz SA,Keiser K,Hargreaves KM

    更新日期:2007-05-01 00:00:00

  • In vitro cytotoxicity evaluation of a novel root repair material.

    abstract:INTRODUCTION:This study examined the effect of a new bioactive dentin substitute material (Biodentine) on the viability of human gingival fibroblasts. METHODS:Biodentine, White ProRoot mineral trioxide aggregate (MTA), and glass ionomer cement were evaluated. Human gingival fibroblasts were incubated for 1, 3, and 7 d...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2012.11.026

    authors: Zhou HM,Shen Y,Wang ZJ,Li L,Zheng YF,Häkkinen L,Haapasalo M

    更新日期:2013-04-01 00:00:00

  • How useful is root canal culturing in predicting treatment outcome?

    abstract::Microbial control--fundamental to healing of apical periodontitis--is central to endodontic practice. The effectiveness of antibacterial measures is generally monitored (in clinical research studies) by microbiological root canal sampling (MRS), which is often used as a predictor for healing. This article addresses th...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,评审

    doi:10.1016/j.joen.2006.11.006

    authors: Sathorn C,Parashos P,Messer HH

    更新日期:2007-03-01 00:00:00

  • The investigation of biocompatibility and apical microleakage of tricalcium phosphate based root canal sealers.

    abstract::The biocompatibility and apical microleakage of tricalcium phosphate based Sankin Apatite (SA) Type I, II, and III root canal sealers were investigated. Teflon tubes containing freshly mixed test materials were implanted in the subcutaneous tissue of mice. The observation periods were 24 h, 7, and 30 days, after which...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/s0099-2399(97)80255-5

    authors: Bilginer S,Esener T,Söylemezoğlu F,Tiftik AM

    更新日期:1997-02-01 00:00:00

  • Anti-inflammatory and Osteogenic Effects of Calcium Silicate-based Root Canal Sealers.

    abstract:INTRODUCTION:An ideal root canal sealer creates a bacteria-resistant seal and exhibits antimicrobial activity, biocompatibility, and osteoconductivity. The aim of this study was to assess the effects of 3 root canal sealers on cell viability, inflammatory response, and osteogenic potential in MC3T3-E1 cells. METHODS:A...

    journal_title:Journal of endodontics

    pub_type: 杂志文章

    doi:10.1016/j.joen.2018.09.006

    authors: Lee BN,Hong JU,Kim SM,Jang JH,Chang HS,Hwang YC,Hwang IN,Oh WM

    更新日期:2019-01-01 00:00:00