House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity.

Abstract:

:A major house dust mite allergen Der f 1 belongs to the papain-like cysteine protease family. This study investigated whether Der f 1 can cleave the latency-associated peptide (LAP) of transforming growth factor (TGF)-beta via its proteolytic activity and activate latent TGF-beta. We found that Der f 1 can cleave LAP and induce the activation of latent TGF-beta, leading to functional Smad signaling. Importantly, these actions of Der f 1 were inhibited by cysteine protease inhibitor E64 or inactivation of the protease activity by heat. Thus, latent TGF-beta may be a direct target of Der f 1 protease activity.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Nakamura Y,Miyata M,Shimokawa N,Ohnuma Y,Katoh R,Ogawa H,Okumura K,Nakao A

doi

10.1016/j.febslet.2009.05.030

subject

Has Abstract

pub_date

2009-06-18 00:00:00

pages

2088-92

issue

12

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(09)00409-8

journal_volume

583

pub_type

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