Abstract:
:A major house dust mite allergen Der f 1 belongs to the papain-like cysteine protease family. This study investigated whether Der f 1 can cleave the latency-associated peptide (LAP) of transforming growth factor (TGF)-beta via its proteolytic activity and activate latent TGF-beta. We found that Der f 1 can cleave LAP and induce the activation of latent TGF-beta, leading to functional Smad signaling. Importantly, these actions of Der f 1 were inhibited by cysteine protease inhibitor E64 or inactivation of the protease activity by heat. Thus, latent TGF-beta may be a direct target of Der f 1 protease activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nakamura Y,Miyata M,Shimokawa N,Ohnuma Y,Katoh R,Ogawa H,Okumura K,Nakao Adoi
10.1016/j.febslet.2009.05.030subject
Has Abstractpub_date
2009-06-18 00:00:00pages
2088-92issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00409-8journal_volume
583pub_type
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