New insights into mitochondrial structure during cell death.

Abstract:

:Mitochondria play a pivotal role in the cascade of events associated with cell death pathways that are involved with several forms of neurodegeneration. Recent findings show that in the Bax/Bak-dependent pathway of apoptosis, the release of cytochrome c from mitochondria is a consequence of two carefully coordinated events: opening of crista junctions triggered by OPA1 oligomer disassembly and formation of outer membrane pores. Both steps are necessary for the complete release of pro-apoptotic proteins. The remodeling of mitochondrial structure accompanies this pathway, including mitochondrial fission, and cristae and crista junction alterations. Yet, there is controversy surrounding the timing of certain remodeling events and whether they are necessary early events required for the release of pro-apoptotic factors or are simply a downstream after-effect. Here, we analyze the current knowledge of mitochondrial remodeling during cell death and discuss what structural alterations occur to this organelle during neurodegeneration, focusing on the higher resolution structural correlates obtained by electron microscopy and electron tomography.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Perkins G,Bossy-Wetzel E,Ellisman MH

doi

10.1016/j.expneurol.2009.05.021

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

183-92

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(09)00203-9

journal_volume

218

pub_type

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