Abstract：
BACKGROUND:Triple-negative breast carcinoma is defined by a primary tumor that is estrogen receptor negative, progesterone receptor negative, and HER2 negative. The current study was performed to determine the relationship of triple-negative tumor status to outcome after breast conservation treatment with radiation. PATIENTS AND METHODS:A total of 519 women with early-stage invasive breast carcinoma underwent breast conservation treatment with radiation. Of the 519 primary breast carcinomas, 90 (17%) were triple negative and 429 (83%) were not triple negative. The median follow-up after treatment was 3.9 years. RESULTS:Compared with the patients without a triple-negative tumor, the patients with a triple-negative tumor had a higher 8-year rate of any local failure (8% vs. 4%, respectively; P = .041) and a lower 8-year rate of freedom from distant metastases (81% vs. 92%, respectively; P = .0066). There were no differences between the 2 groups for local-only first failure, overall survival, or contralateral breast cancer (all P >or= .3). On multivariate analysis, triple-negative tumors had an increased risk for any local failure (hazard ratio, 2.58), although this difference was not statistically significant (P = .097). CONCLUSION:After breast conservation treatment with radiation, women with a triple-negative tumor had a higher rate of local failure compared with women without a triple-negative tumor. However, the absolute difference in local failure between the 2 groups was relatively small and therefore does not preclude breast conservation treatment with radiation for triple-negative early-stage invasive breast carcinoma.
journal_name
Clin Breast Cancerjournal_title
Clinical breast cancerauthors
Solin LJ,Hwang WT,Vapiwala Ndoi
10.3816/CBC.2009.n.018subject
Has Abstractpub_date
2009-05-01 00:00:00pages
96-100issue
2eissn
1526-8209issn
1938-0666pii
S1526-8209(11)70652-8journal_volume
9pub_type
杂志文章abstract：:Bisphosphonates (BPs) are approved for preventing the skeletal-related events associated with malignant bone disease. Several studies indicate that they may also prevent cancer therapy-induced bone loss. Multiple preclinical and early clinical studies provide evidence of the anticancer activity of BPs, including an in...
journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/CBC.2010.n.047
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abstract：:Fulvestrant, an estrogen receptor antagonist that downregulates the estrogen receptor but has no known agonist effects, has been evaluated in 2 randomized trials involving postmenopausal women with hormone receptor-positive, progressive advanced-stage breast cancer after disease progression with antiestrogen therapy. ...
journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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journal_title：Clinical breast cancer
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.1016/j.clbc.2020.03.007
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journal_title：Clinical breast cancer
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doi：10.3816/CBC.2006.n.030
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/cbc.2004.s.006
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abstract：:Sentinel lymph node dissection (SLND) is a minimally invasive technique to stage axillary lymph nodes in breast cancer. The complications associated with SLND are minimal, especially when compared to routine axillary lymph node dissection (ALND), and it can be performed with an overall identification rate of greater t...
journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/CBC.2000.n.010
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.3816/CBC.2010.n.008
更新日期：2010-02-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/CBC.2005.n.006
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2018.05.006
更新日期：2018-10-01 00:00:00
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journal_title：Clinical breast cancer
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2018.11.001
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2017.10.012
更新日期：2018-04-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.3816/CBC.2006.n.045
更新日期：2006-10-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/cbc.2008.s.001
更新日期：2008-03-01 00:00:00
abstract：:The androgen receptor (AR) is increasingly considered as a potential biomarker for breast cancer. Nevertheless, the prognostic value of AR expression in patients with triple negative breast cancer (TNBC) remains controversial. Therefore, in this meta-analysis, we investigated AR expression and its impact on survival o...
journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.1016/j.clbc.2020.01.002
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.3816/CBC.2007.n.055
更新日期：2007-12-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.1016/j.clbc.2016.12.010
更新日期：2017-07-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2018.04.012
更新日期：2018-10-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.3816/CBC.2007.n.029
更新日期：2007-08-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2012.09.006
更新日期：2012-12-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2017.10.019
更新日期：2018-08-01 00:00:00
