Ketogenic diet in Indian children with uncontrolled epilepsy.

Abstract:

OBJECTIVE:To evaluate the efficacy of the ketogenic diet in Indian children with uncontrolled epilepsy. STUDY DESIGN:Prospective observational study. SETTING:Hospital based. PATIENTS:105 children (age 4 months to 18 years) with uncontrolled epilepsy enrolled in the ketogenic diet program over a period of 9 years and followed up for 25.7+/- 20.3 months (median:17 months) on the ketogenic diet. MAIN OUTCOME MEASURES:Reduction in seizure frequency and comparison of improvement in two main groups of epilepsies, namely epileptic encephalopathies and localization related epilepsies. RESULTS:Thirty seven (35%) out of 105 children dropped out of the study and 68 remained on the diet. Thirty nine (37%) achieved 100% control, 23 (22%) achieved between 90 and 99% control, 7 (6.8%) achieved between 75 and 90% control, and 16 (15.2%) achieved between 50 and 75% control. Twenty (19%) achieved less than 50% control. Epileptic encephalopathies had a better response than localization related epilepsies. CONCLUSION:The Indian version of ketogenic diet used is well tolerated and efficacious in controlling difficult-to-control epilepsy in children. Epileptic encephalopathies respond better than localization related epilepsies.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Nathan JK,Purandare AS,Parekh ZB,Manohar HV

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

669-73

issue

8

eissn

0019-6061

issn

0974-7559

pii

S097475590600494-1

journal_volume

46

pub_type

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