Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration.

Abstract:

PURPOSE OF REVIEW:The most important recent advance in the treatment of neovascular age-related macular degeneration (AMD) is the development of antivascular endothelial growth factor (anti-VEGF) therapeutic agents that preserve and improve visual acuity by arresting choroidal neovascular growth and reducing vascular permeability. This review describes the current literature on the use of this therapeutic approach in the management of neovascular AMD. RECENT FINDINGS:Two anti-VEGF agents, pegaptanib sodium and ranibizumab, are currently approved by the United States Food and Drug Administration for the treatment of neovascular AMD. In addition, off-label use of a third anti-VEGF agent, bevacizumab, as a treatment option for neovascular AMD has become common worldwide. Other anti-VEGF agent strategies that have shown efficacy include small interfering RNA agents to silence the VEGF gene and receptor and the fusion protein VEGF trap. SUMMARY:The accumulation of preclinical and clinical evidence implicating VEGF-A in the pathogenesis of neovascular AMD has provided a strong rationale for the development of anti-VEGF agents for this disease. Anti-VEGF therapies have been used successfully in the clinic, encouraging their use in the treatment of other neovascular eye diseases.

journal_name

Curr Opin Ophthalmol

authors

Ciulla TA,Rosenfeld PJ

doi

10.1097/ICU.0b013e32832d25b3

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

158-65

issue

3

eissn

1040-8738

issn

1531-7021

pii

00055735-200905000-00004

journal_volume

20

pub_type

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