Abstract:
PURPOSE OF REVIEW:The most important recent advance in the treatment of neovascular age-related macular degeneration (AMD) is the development of antivascular endothelial growth factor (anti-VEGF) therapeutic agents that preserve and improve visual acuity by arresting choroidal neovascular growth and reducing vascular permeability. This review describes the current literature on the use of this therapeutic approach in the management of neovascular AMD. RECENT FINDINGS:Two anti-VEGF agents, pegaptanib sodium and ranibizumab, are currently approved by the United States Food and Drug Administration for the treatment of neovascular AMD. In addition, off-label use of a third anti-VEGF agent, bevacizumab, as a treatment option for neovascular AMD has become common worldwide. Other anti-VEGF agent strategies that have shown efficacy include small interfering RNA agents to silence the VEGF gene and receptor and the fusion protein VEGF trap. SUMMARY:The accumulation of preclinical and clinical evidence implicating VEGF-A in the pathogenesis of neovascular AMD has provided a strong rationale for the development of anti-VEGF agents for this disease. Anti-VEGF therapies have been used successfully in the clinic, encouraging their use in the treatment of other neovascular eye diseases.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Ciulla TA,Rosenfeld PJdoi
10.1097/ICU.0b013e32832d25b3subject
Has Abstractpub_date
2009-05-01 00:00:00pages
158-65issue
3eissn
1040-8738issn
1531-7021pii
00055735-200905000-00004journal_volume
20pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Recent advances in the design and material of phakic intraocular lenses have made them very predictable, safe and effective. The use of these lenses in refractive surgery is expected to increase very significantly in the near future. The aim of this review is to update the reader regarding the recent ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283009f0a
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:As Reese first described the vitreomacular traction (VMT) syndrome in 1970, the knowledge base about the disease has been changing over time due to the advent of the high-definition optical coherence tomography (HD-OCT). The aim of this article was to present the current information on the pathophysio...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328352404c
更新日期:2012-05-01 00:00:00
abstract::Acute demyelinating optic neuritis associated with multiple sclerosis (MS) is the most common cause of inflammation of the optic nerve. The Optic Neuritis Treatment Trial (ONTT) has provided important clinical data on the use of corticosteroids, and demonstrated that patients with characteristic inflammatory lesions w...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200212000-00006
更新日期:2002-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Corneal transplantation is the most commonly performed solid organ transplantation in the world. Despite a glorious history of more than a 100 years, the success of conventional corneal transplantation surgery is marred by problems like graft rejection,graft infection and associated glaucoma due to lo...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to collate evidence and make recommendations regarding the use of multifocal intraocular lenses in patients with glaucoma. RECENT FINDINGS:Multifocal intraocular implants have been in use since the 1980s. Several studies have been done comparing their advantages and disa...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328011d108
更新日期:2007-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Fine-needle aspiration biopsy of choroidal melanoma offers an opportunity to determine the prognosis for metastasis and provide tissue resources for further study to develop molecular-based targeted therapies. Patients increasingly desire as much information as possible about their cancer so that they...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835ff001
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review the retinal complications that may occur after laser-assisted in situ keratomileusis (LASIK). RECENT FINDINGS:One study investigated the incidence, characteristics, and surgical management of rhegmatogenous retinal detachment after LASIK surgery in myopia. The inc...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3282fb7c15
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Optical coherence tomography (OCT) aids in the diagnosis and long-term monitoring of various ocular diseases, including glaucoma. Initially, the retinal nerve fiber layer was the only OCT structural parameter used in glaucoma. Subsequent research has resulted in more retinal and optic nerve head param...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000231
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Meibomian gland dysfunction (MGD) is understood to be a highly prevalent, chronic progressive disease and the leading cause of dry eye. All available published peer-reviewed results of the novel vectored thermal pulsation therapy for patients with MGD are investigated. RECENT FINDINGS:The PubMed and ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000165
更新日期:2015-07-01 00:00:00
abstract::This review of recent articles on ocular toxicology concentrates on undesirable effects on the eye induced by systemically used xenobiotics. These include color vision deficiencies or visual field deterioration related to antiepileptic drugs, elevated intraocular pressure associated with inhaled corticosteroids, retin...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199712000-00016
更新日期:1997-12-01 00:00:00
abstract::Radiotherapy has become increasingly important for the treatment of complicated choroidal hemangiomas. In recent years, a broad spectrum of different radiotherapeutic options that either replace or complement the conventional therapeutic approach by photocoagulation has been recommended. This article reviews the vario...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199806000-00009
更新日期:1998-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The history, pharmacology, indications, complications, and success rates of botulinum administration are discussed in this review as they relate to strabismus and associated conditions. RECENT FINDINGS:Botulinum has been used to treat strabismus and a variety of other ocular conditions for over three...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000243018.97627.4c
更新日期:2006-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Chemodenervation has evolved greatly over the past 30 years since botulinum toxin was first introduced as a therapeutic injection for managing strabismus. RECENT FINDINGS:Botulinum toxins are now accepted as a first-line treatment for patients suffering from spasms secondary to facial dystonias. Thes...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200310000-00003
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Myelin oligodendrocyte glycoprotein (MOG)-IgG-associated optic neuritis has been established as a new entity of optic neuropathy. We will review recent advances in pathophysiology, diagnosis, and clinical manifestations of MOG-IgG-associated optic neuritis to better understand its distinctive characte...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000520
更新日期:2018-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review new developments in the medical and surgical treatment options for benign essential blepharospasm (BEB). RECENT FINDINGS:Botulinum toxin injections remain the mainstay treatment for BEB with several formulations currently commercially available. Reports in the medical literature support pho...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000500
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an unstructured review of the recent literature on the role of optical coherence tomography (OCT) in cataract surgery with specific focus on cystoid macular edema (CME) on the basis of expert opinion of the authors. RECENT FINDINGS:OCT appears to be a useful method to reveal clinically rel...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/icu.0b013e3283199162
更新日期:2009-01-01 00:00:00
abstract::Sjögren syndrome is a chronic systemic disease characterized by polyglandular tissue destruction leading to keratoconjunctivitis sicca (KCS) and xerostomia. Patients with primary Sjögren syndrome show evidence of KCS and xerostomia, whereas patients with secondary Sjögren syndrome suffer from KCS, xerostomia, and an a...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200012000-00011
更新日期:2000-12-01 00:00:00
abstract::The detection and treatment of choroidal melanoma early in its natural course is critical to providing the patient with the best prognosis. Patients with small choroidal melanoma (< 4 mm thickness) develop metastasis in 16% of cases at 5 years follow up, whereas those with medium choroidal melanoma (4-8 mm thickness) ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200206000-00001
更新日期:2002-06-01 00:00:00
abstract::An improvement in our understanding of the pathogenesis and natural history of idiopathic macular holes over the last 10 years has led to a more optimistic and interventionist approach to the surgical management of this vitreoretinal disorder. This article reviews the theories postulated for the pathogenesis of this c...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199706000-00015
更新日期:1997-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in experimental studies of optic nerve regeneration to better understand the pathophysiology of axon regrowth and provide insights into the future treatment of numerous optic neuropathies. RECENT FINDINGS:The optic nerve is part of the central nervous system and cannot regenerate if i...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000417
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Cataracts are a significant cause of blindness and visual impairment worldwide. The present article reviews the literature and describes the current extent of cataracts globally, barriers to treatment, and recommendations for improving the treatment of cataracts. RECENT FINDINGS:Prevalence and absolu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000340
更新日期:2017-01-01 00:00:00
abstract::A comprehensive review of the ophthalmic literature on cataracts during the past year is presented. Topics covered include new epidemiologic associations, diabetic cataracts, and syndromes involving cataracts. Data from the Beaver Dam Eye Study suggest the presence of a recessive gene for nuclear sclerosis. Estrogen e...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1995-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Intraocular lens (IOL) calculations in patients with keratoconus and other keratoectatic disorders continues to be a challenge for today's cataract surgeon. In this article, we review data published over the past 18 months (June 2018 to January 2020). RECENT FINDINGS:Cataract surgery in keratoconus p...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000671
更新日期:2020-07-01 00:00:00
abstract::Cystoid macular edema (CME) remains a troublesome problem after cataract surgery and other types of ocular surgical procedures. It is recognized as the most frequent cause of decreased vision in patients following cataract surgery. Although the disease was first described more than 40 years ago, its cause is unclear, ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200002000-00010
更新日期:2000-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of micro...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000271
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To perform a literature review of articles published between 2016 and 2017 to assess recent advances in intraocular lens (IOL) selection. RECENT FINDINGS:A literature review revealed five areas of recent study including advances in biometric technology, formula selection for challenging eyes, accurat...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000493
更新日期:2018-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This article presents, summarizes, and interprets the most recent advances in the study and understanding of the lamina cribrosa in glaucoma, in the context of previous work. RECENT FINDINGS:The lamina is an active living structure that responds to strain by changing morphology at the micro-scale and...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000354
更新日期:2017-03-01 00:00:00
abstract::Patients with Alzheimer's disease may present to the ophthalmologist with visual symptoms that precede or overshadow the features of dementia. This visual variant of Alzheimer's disease has been recognized only recently and typically appears in late middle age as progressive visuospatial and reading dysfunction, with ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe recent advances in clinical features, diagnostic tools, and treatment modalities for lymphoproliferative diseases affecting the ocular adnexa. RECENT FINDINGS:A close relationship of non-Hodgkin lymphoma with long-term use of aspirin and nonaspirin nonsteroidal antiinflammatory drugs has ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000139302.16648.80
更新日期:2004-10-01 00:00:00
abstract::Glaucoma is a progressive optic neuropathy that has a multi-factorial etiology. The most important risk factor is certainly an increased intraocular pressure. However, clinical observations have indicated that factors other than increased intraocular pressure also damage the neural tissue in glaucomatous optic neuropa...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199804000-00016
更新日期:1998-04-01 00:00:00