HIV infection and the central nervous system: a primer.

Abstract:

:The purpose of this brief review is to prepare readers who may be unfamiliar with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and the rapidly accumulating changes in the epidemic by providing an introduction to HIV disease and its treatment. The general concepts presented here will facilitate understanding of the papers in this issue on HIV-associated neurocognitive disorders (HAND). Toward that end, we briefly review the biology of HIV and how it causes disease in its human host, its epidemiology, and how antiretroviral treatments are targeted to interfere with the molecular biology that allows the virus to reproduce. Finally, we describe what is known about how HIV injures the nervous system, leading to HAND, and discuss potential strategies for preventing or treating the effects of HIV on the nervous system.

journal_name

Neuropsychol Rev

journal_title

Neuropsychology review

authors

Ellis RJ,Calero P,Stockin MD

doi

10.1007/s11065-009-9094-1

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

144-51

issue

2

eissn

1040-7308

issn

1573-6660

journal_volume

19

pub_type

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