A prospective study of false-positive diagnosis of micrometastatic cells in the sentinel lymph nodes in colorectal cancer.

Abstract:

INTRODUCTION:Sentinel lymph node mapping (SLNM) with multilevel sections (MLS) and cytokeratin immunohistochemistry (CK-IHC) of sentinel lymph nodes (SLNs) upstages 15-20% of patients (pts). False-positive SLNs occur in breast cancer due to mechanical transport of cells during mapping procedures, or to pre-existing benign cellular inclusions. Our prospective study evaluated whether colorectal mapping procedures alone caused false positives. METHODS:A total of 314 pts underwent SLNM with blue dye. Ninety of the pts underwent a second mapping in normal bowel away from the primary tumor. The first 1-5 blue nodes near the primary tumor were marked as SLNs; those near the second injection site were marked as nontumor SLNs (nt-SLNs). All SLNs and nt-SLNs were evaluated by MLS and CK-IHC. RESULTS:Of 314 pts, 30 had benign tumor and 284 had invasive cancer. SLNM was successful in 274/284 (96.5%) invasive cancer pts, with 728 SLNs identified. Forty-six of the 274 pts (16.8%) had low-volume metastasis in 57 SLNs: 31 pts (11.3%) had 38 SLNs with micrometastasis (>0.2 mm,

journal_name

Ann Surg Oncol

authors

Wiese D,Saha S,Yestrepsky B,Korant A,Sirop S

doi

10.1245/s10434-009-0497-2

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

2166-9

issue

8

eissn

1068-9265

issn

1534-4681

journal_volume

16

pub_type

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