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Mechanisms for the initiation of human atrial fibrillation.

Abstract：

:Understanding of the mechanisms underlying atrial fibrillation (AF) remain limited. However, both persistent and paroxysmal AF likely initiate via the interaction of triggers such as premature atrial beats with 'substrate', that includes static components such as fibrosis and scar, as well as dynamic alterations that may include the rate-response of repolarization and conduction, autonomic modulation and stretch. This article attempts to synthesize concepts for AF initiation from in silico, in vitro and in vivo animal data and human studies and apply them to the spectrum of disease processes that comprise clinical AF. Further investigation is urgently needed to translate these discoveries into effective therapy.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Krummen DE,Narayan SM

doi

10.1016/j.hrthm.2009.03.004

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

S12-6

issue

8 Suppl

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(09)00279-3

journal_volume

6

pub_type

杂志文章

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