Abstract:
:Understanding of the mechanisms underlying atrial fibrillation (AF) remain limited. However, both persistent and paroxysmal AF likely initiate via the interaction of triggers such as premature atrial beats with 'substrate', that includes static components such as fibrosis and scar, as well as dynamic alterations that may include the rate-response of repolarization and conduction, autonomic modulation and stretch. This article attempts to synthesize concepts for AF initiation from in silico, in vitro and in vivo animal data and human studies and apply them to the spectrum of disease processes that comprise clinical AF. Further investigation is urgently needed to translate these discoveries into effective therapy.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Krummen DE,Narayan SMdoi
10.1016/j.hrthm.2009.03.004subject
Has Abstractpub_date
2009-08-01 00:00:00pages
S12-6issue
8 Suppleissn
1547-5271issn
1556-3871pii
S1547-5271(09)00279-3journal_volume
6pub_type
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