Abstract:
:Clinical needs for new antifungal agents have steadily increased with the rise and alteration in spectrum of invasive mycoses in children and neonates having AIDS, malignancies and undergoing immunosuppressive therapies. Several new options are now available for management of serious fungal infections. The aim of this review is to summarize the key features of the new antifungal agents and novel targets being investigated for the treatment of fungal infections, with special reference to its use in the treatment of pediatric fungal infections. New triazoles have broad spectrum of activity with voriconazole presently being the drug of choice against invasive aspergillosis, and posaconazole is the possible first substitute of amphotericin B against zygomycosis. Echinocandins with new mode of action of inhibition of fungal cell wall polysaccharide synthesis are effective in treating candidemia and invasive candidiasis. Some of these agents are however, still awaiting FDA approval for their use in pediatric practice.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Das S,Shivaprakash MR,Chakrabarti Asubject
Has Abstractpub_date
2009-03-01 00:00:00pages
225-31issue
3eissn
0019-6061issn
0974-7559journal_volume
46pub_type
杂志文章,评审abstract::Social, cultural and economic factors, beside medical causes, contribute to the high percentage of infant mortality in India. This study was carried out in 12 villages in the area of the Rural Health Training Centre, Naila, India; all villages were being regularly visited by paramedical staff and doctors. During 197...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract:OBJECTIVE:To assess efficacy and safety of High flow nasal cannula therapy (HFNC) as primary mode of treatment for children with respiratory distress. METHODS:Consecutive patients (1 mo-16 years) with respiratory distress were assessed for respiratory clinical score, COMFORT score and saturation to FiO2 (SF) ratio. R...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of rotavirus diarrhea among hospitalized children less than 5 years of age in Kerala State and to determine the circulating strains of rotavirus in Kerala. DESIGN:Multicenter, cross-sectional study. SETTING:Eight representative hospitals in Kunnathunadu Thaluk, Ernakulam district,...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0329-8
更新日期:2014-01-01 00:00:00
abstract::A major purpose of the immunization coverage evaluation surveys to document the vaccination status of children aged 1-2 years was to determine the true picture of the immunization status of the target population and to identify areas which need strengthening. Immunization coverage evaluation surveys were carried out f...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Massive open online courses (MOOCs) are currently the buzz word in the field of e-learning. By definition, MOOCs are massive courses considering the number of participants enrolled across the globe per course, are open accessed, and are available online. MOOCs have evolved along the trajectory of correspondence course...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2019-06-15 00:00:00
abstract:OBJECTIVES:To evaluate efficacy of polymerase chain reaction (PCR), using the insertion sequence IS6110 as target for DNA, to detect Mycobacterium tuberculosis in body fluids of children with suspected tuberculosis (TB). SETTING:Hospitalized patients. METHODS:A comparison of PCR on body fluids, Acid Fast Bacilli stai...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::We report a case of primary hyperparathyroidism associated with prolonged hungry syndrome (HBS) after parathyroid adenomectomy in a 10-year-old girl. Bone mineral density (BMD) revealed severe loss of cancellous BMD. Overt bone disease, high alkaline phosphatase, decreased cancellous BMD and a large adenoma can be use...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract::A 3 year old child was brought with fever, left parotid swelling and altered sensorium. Cultures from blood, pus and throat swab grew Burkholderia pseudomallei. A diagnosis of septicemic melioidosis with encephalopathy was made. She recovered following treatment with parenteral ceftazidime for 14 days, and 6 months of...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-010-0106-2
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To assess the Vitamin A status of pregnant women in their third trimester using maternal serum retinol levels as the indicator; and (ii) To assess the impact of postpartum Vitamin A supplementation on the Vitamin A status of exclusively breastfed infants. DESIGN:Prospective randomized single blind controlled...
journal_title:Indian pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-11-01 00:00:00
abstract::This presentation deals with 110 surgically proven cases of abdominal tuberculosis in the pediatric age group. The protean clinical profiles and complications of the disease entity made the clinical diagnosis difficult; the investigations were also found non-pathognomonic. The most common type of pathology seen was ad...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Twenty six perinatally acquired HAART naive HIV positive children asymptomatic for cardiac disease in age group of 1-9 years were evaluated for cardiac abnormalities by echocardiography. All children were classified according to the revised CDC classification for HIV infection in children. 20 (76.9 percent) patients h...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
abstract::Guillain-Barre syndrome is a post infectious polyradiculoneuropathy. It is equally prevalent in both the adult and the pediatric populations. Guillain-Barre syndrome following dengue fever is not a classically described entity and has not been reported in children. ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Despite a reduction in disease burden of vaccine preventable diseases through childhood immunization, considerable progress needs to be made in terms of ensuring efficiency and equity of vaccination coverage. OBJECTIVE:To conduct a systematic review to identify and explore factors associated with inequities...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s13312-012-0063-z
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To describe the clinical profile of children with bacteriologically confirmed tuberculosis. STUDY DESIGN:A multicentric study was conducted in three hospitals in Chennai city between July 1995 and December 1997. Children aged 6 months to 12 years with signs and symptoms suggestive of tuberculosis were invest...
journal_title:Indian pediatrics
pub_type: 杂志文章,多中心研究
doi:
更新日期:2008-09-01 00:00:00
abstract::In order to evaluate clinical and bacteriological efficacy of Cefpodoxime Proxetil (CP) in typhoid fever in comparison to cefixime (CF), we assessed 140 children with suspected typhoid fever. Fulfilling inclusion criteria finally 40 culture confirmed typhoid fever were allocated in randomized double blind clinical tri...
journal_title:Indian pediatrics
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2007-11-01 00:00:00
abstract::We conducted this study to determine the fatty acid composition of breastmilk of Israeli women and compare it with baby milk substitutes. Samples of mature breast milk, from 29 lactating Israeli Jewish mothers were collected during feedings. Total milk lipids extracts were transmethylated and analyzed by using an impr...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0277-8
更新日期:2013-11-08 00:00:00
abstract::Thrombocytosis is a frequent finding in hemograms obtained from hospitalized and ambulatory children due to the widespread use of automated blood cell counters. Pediatricians are commonly puzzled in cases of thrombocytosis to determine the underlying cause and the need for therapy. The purpose of this review is to ass...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2008-08-01 00:00:00
abstract::A 6 month-old infant presenting with severe mitral regurgitation was found to have hepatosplenomegaly, corneal clouding, and Alder-Reilly granules in the leucocytes. Extremely low levels of beta glucuronidase confirmed the diagnosis of Sly disease (Mucopolysaccharidosis VII). This is the first case of MPS VII reported...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::Salmonella senftenberg was isolated from the stools of 35 newborns between June, 1987 and September, 1988. Twenty nine (82.8%) babies were preterms and twenty six (74%) babies were less than 2,000 grams in weight. All of them were symptomatic within 6 days of life, 74.3% (26) within 4 days. All of them had loose stool...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::This prospective study was conducted in a teaching hospital to identify and analyze medical errors in pediatric practice. All admitted children underwent surveillance for medical errors. Of 457 errors identified in 1286 children, medication errors were 313 (68.5%), those related to treatment procedures were 62 (13.6%)...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Lipoid pneumonia is a rare form of pneumonia caused by aspiration of fatty substances. CASE CHARACTERISTICS:Acute respiratory distress syndrome in an infant due to accidental aspiration of baby oil massage. INTERVENTION:Large volume bronchoalveolar lavage. OUTCOME:Gradual recovery over a period of 5 month...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-015-0569-2
更新日期:2015-01-01 00:00:00
abstract::Childhood Hodgkins Disease (HD) is a lymphoma that displays characteristic epidemiological, clinical and pathological features according to various geographic areas, particularly according to the socio-economic level of a given country. India presents a similar sex, age and subtype distribution as other emerging count...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Outcome of pseudomonas enteric fever is unpredictable as multiple systemic lethal complications occur abruptly. CASE CHARACTERISTICS:A 9-month-old girl with multiple ileal perforations, leukocoria, ecthyma gangrenosum, hemiplegia and a perforated ulcer in the soft palate. Blood culture suggested Pseudomonas...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-015-0741-8
更新日期:2015-10-01 00:00:00
abstract::Hospital acquired enteric infections were investigated by studying 3138 children under 5 years of age who were admitted without diarrhea in nine medical words of a pediatric hospital, Calcutta during the period between March and September 1987. Three hundred and twenty (10.2%) children developed nosocomial diarrhea du...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To study the effect of oil massage on growth and neurobehavior in preterm babies less than 1500 g. DESIGN:Randomized Controlled Trial. SETTING:Tertiary level neonatal unit of a teaching hospital. SUBJECTS:Neonates with birth weight <1500 grams, gestation >37 weeks, receiving enteral feeds of at least 100 m...
journal_title:Indian pediatrics
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2005-11-01 00:00:00
abstract::The phenotypic description of SHORT syndrome (OMIM- 269880) is expanding since its initial description in 1975. There have been 26 case reports till date but the genetic locus of this syndrome is elusive. Involvement of PITX2 gene initially envisaged is probably is not the only gene involved but has an important role ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0099-8
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Mediastinal pancreatic pseudocyst is a rare complication of pancreatitis. CASE CHARACTERISTICS:An 8-year-old boy with chest pain and shortness of breath. Computed tomography of chest showed a cystic mass in the mediastinum. The cyst aspirate revealed high amylase and lipase levels, suggestive of pancreatic ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2018-03-15 00:00:00
abstract:OBJECTIVE:To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery. METHODS:This retrospective study investigated 103 infants with CHD undergoing cardiac surgery between January 2013 and February 2016. Pre- and postoperative amplitude-integrated electroencep...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2020-02-15 00:00:00
abstract::Audit in medicine is a well tried means of assessing the quality of practice by using acceptable measures of outcome. Audit in maternal and child health has been limited to fatal outcomes such as maternal and perinatal deaths. The outcome of audit is of interest to the providers, the health authorities and the consume...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Data on blood pressure recorded by oscillometric method is limited. OBJECTIVE:To develop simplified tables and charts of blood pressure recorded by oscillometric method in children. DESIGN:Cross-sectional. SETTING:Ballabhgarh, Haryana. PARTICIPANTS:Healthy school-children. MAIN OUTCOME MEASURES:Blood pr...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-015-0749-0
更新日期:2015-11-01 00:00:00