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Genome sequence comparison of Col and Ler lines reveals the dynamic nature of Arabidopsis chromosomes.

Abstract：

:Large differences in plant genome sizes are mainly due to numerous events of insertions or deletions (indels). The balance between these events determines the evolutionary direction of genome changes. To address the question of what phenomena trigger these alterations, we compared the genomic sequences of two Arabidopsis thaliana lines, Columbia (Col) and Landsberg erecta (Ler). Based on the resulting alignments large indels (>100 bp) within these two genomes were analysed. There are approximately 8500 large indels accounting for the differences between the two genomes. The genetic basis of their origin was distinguished as three main categories: unequal recombination (Urec)-derived, illegitimate recombination (Illrec)-derived and transposable elements (TE)-derived. A detailed study of their distribution and size variation along chromosomes, together with a correlation analyses, allowed us to demonstrate the impact of particular recombination-based mechanisms on the plant genome evolution. The results show that unequal recombination is not efficient in the removal of TEs within the pericentromeric regions. Moreover, we discovered an unexpectedly high influence of large indels on gene evolution pointing out significant differences between the various gene families. For the first time, we present convincing evidence that somatic events do play an important role in plant genome evolution.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Ziolkowski PA,Koczyk G,Galganski L,Sadowski J

doi

10.1093/nar/gkp183

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

3189-201

issue

10

eissn

0305-1048

issn

1362-4962

pii

gkp183

journal_volume

37

pub_type

杂志文章

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