Abstract:
:HSP70 promoter-driven gene therapy and inhibition of HSP90 activity with small molecule inhibitors are two shining points in a newly developed cohort of cancer treatment. For HSP70 promoters, high efficiency and heat inducibility within a localized region make it very attractive to clinical translation. The HSP90 inhibitors exhibit a broad spectrum of anticancer activities due to the downstream effects of HSP90 inhibition, which interfere with a wide range of signaling processes that are crucial for the malignant properties of cancer cells. In this review article, we summarize exciting applications of newly emerged molecular imaging techniques as they relate to HSP, including protein-protein interactions of HSP90 complexes, therapeutic response of tumors to HSP90 inhibitors, and HSP70 promoters-controlled gene therapy. In the HSPs context, molecular imaging is expected to play a vital role in promoting drug development and advancing individualized medicine.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Niu G,Chen Xdoi
10.1016/j.ejrad.2009.01.052subject
Has Abstractpub_date
2009-05-01 00:00:00pages
294-304issue
2eissn
0720-048Xissn
1872-7727pii
S0720-048X(09)00074-6journal_volume
70pub_type
杂志文章,评审abstract:OBJECTIVE:To compare the quality of contrast enhancement and hepatic CT images acquired using bolus tracking technique at two different time points and those acquired with fixed scan delay technique using a previous bolus tracking data. MATERIALS AND METHODS:Fifty patients who underwent 3 different hepatic CT exams (2...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2012.02.022
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of different spiral CT examination protocols suitable for clinical use on image quality and to assess the observer dependence in interactive real-time virtual bronchoscopy. METHODS AND PATIENTS:Real-time perspective volume rendering of the airways in twenty normal patients based on ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(99)00088-1
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To retrospectively evaluate the detection performance of benign and malignant breast masses using 3D volume data obtained by ABUS and to determine lesion variables which affect detectability. METHODS:Between November and December of 2007, bilateral whole breast US images were obtained using ABUS in 67 conse...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.01.074
更新日期:2011-04-01 00:00:00
abstract::The new American Thoracic Society/European Respiratory Society (ATS/ERS) update to the multidisciplinary classification of idiopathic interstitial pneumonias (IIPs) defines both rare IIPs and rare histologic patterns of IIPs. Although these diseases are rare, each has some distinguishing imaging and pathologic charact...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.11.032
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Apparent diffusion coefficients (ADCs) derived from diffusion-weighted magnetic resonance imaging (DW-MRI) and metabolic parameters derived from 18F-FDG positron emission tomography (PET) are promising prognostic indicators for head and neck squamous cell carcinoma (SCC). However, the relationship between them ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109070
更新日期:2020-08-01 00:00:00
abstract::Pelvic fractures are common in polytrauma and continue to pose a difficult management dilemma for even the most experienced clinicians. Due to the high energy mechanisms involved, there are often multiple other injuries and many specialists may be involved. Deriving an effective management strategy relies on early dia...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2010.01.025
更新日期:2010-04-01 00:00:00
abstract::Tuberculosis [TB] of the appendicular skeleton is an uncommon infection caused by the tuberculous bacilli and constitutes only 1-3% of all tuberculosis infections. MR imaging features of tuberculous arthritis include bone marrow oedema, cortical erosions, synovitis, joint effusion, tenosynovitis, soft tissue collectio...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2003.11.003
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:Diagnosing acute pancreatitis (AP) may be challenging in patients with acute abdominal pain but missing threefold increased serum lipase levels (Lip-). This studyaims both to characterize these patients using clinical, radiological and mortality data, and to assess the group of patients who need contrast-enh...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2017.08.038
更新日期:2017-10-01 00:00:00
abstract::The purpose of this study was to assess the reproducibility of functional and anatomical parameters of swallowing events as determined by real-time MRI at 40 ms temporal resolution (25 frames per second). Twenty-three consecutive patients with gastroesophageal reflux disease (GERD) underwent real-time MRI of the gastr...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2018.04.029
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To assess the feasibility and advantages of high-resolution high-contrast magnetic resonance neurography (HRHC-MRN) for visualizing the morphology and pathology of the peripheral branches of cranial nerves. MATERIALS:cMRN (3D SPACE STIR sequence) and HRHC-MRN (contrast enhanced 3D SPACE STIR sequence) were per...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109137
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The purpose of this retrospective study was to evaluate transarterial catheter embolization (TAE) for the management of hemarthrosis of the knee in 35 patients treated at two different hospitals. METHODS:From June 1998 through January 2011, 35 patients (22 men and 13 women, mean age 57 years) underwent TAE ...
journal_title:European journal of radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejrad.2011.11.016
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To evaluate the additional value of the color coding of dynamic data using the 3TP method in the evaluation of contrast-enhanced breast MRI for readers with different levels of experience. MATERIALS AND METHODS:A total of 52 lesions were included in this study, 25 malignant and 27 benign. All lesions were eval...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.03.053
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To evaluate the influence of radiation dose settings and reconstruction algorithms on the measurement accuracy and reproducibility of semi-automated pulmonary nodule volumetry. MATERIALS AND METHODS:CT scans were performed on a chest phantom containing various nodules (10 and 12mm; +100, -630 and -800HU) at 12...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.01.025
更新日期:2014-05-01 00:00:00
abstract::The aim of this fMRI study was to evaluate the motor reorganization (cerebral plasticity) and the risk of motor deficit in patients presenting with tumors and vascular malformations, within the framework of their pre-surgical planning. Functional MR imaging data was obtained from 17 patients. Ten patients (seven with ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(02)00083-9
更新日期:2003-05-01 00:00:00
abstract::An unusual complication from subclavian venous catheterization is reported. A 63 year old white female with thrombocytopenia following chemotherapy for erythroleukemia developed mediastinal haematoma after inserting a left subclavian central catheter. Subsequent bilateral pleural effusion and right sided pneumothorax ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:PURPOSE:Groove pancreatitis is a rare focal form of chronic pancreatitis that occurs in the pancreaticoduodenal groove between the major and minor papillae, duodenum and pancreatic head. Radiologic appearance and clinical presentation can result in suspicion of malignancy rendering pancreaticoduodenectomy inevitable. T...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.05.019
更新日期:2014-08-01 00:00:00
abstract::This paper discusses ten patients who developed acute cholecystitis during the postoperative period following surgery which did not involve the gall bladder. All were examined with ultrasound during the first two weeks after surgery and were diagnosed as acute cholecystitis. Six (60%) had complications such as empyema...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
abstract::Physical exercise and sports increase muscular mass and the remodelling process of bones. The increment of bone depends on the type and the quality of sport. Short-term high-performance activities such as sprint, tennis, fencing lead to increased bone mineral density as well as weight lifting or heavy athletics. Swimm...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(97)00113-7
更新日期:1998-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to explore the nature of lesions in the pelvis and the long tubular bones that, with MR imaging, were found to contain both fat and fluid-like signal intensity and to correlate these findings with those of radiography, histologic analysis, and clinical and radiographic follow-up. ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2004.02.008
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:To quantify the distribution of morphologic appearances of urethral anatomy and measure variables of urethral sphincter anatomy in continent, nulliparous, pregnant women by high resolution magnetic resonance imaging (MRI). MATERIALS AND METHODS:We studied fifteen women during their first pregnancy. We def...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.08.046
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To assess the effect of a breath-hold after forced expiration on the rate of pneumothorax after computed tomography (CT)-guided transthoracic needle biopsy of pulmonary lesions. MATERIALS AND METHODS:Between January 2008 and December 2011, percutaneous CT-guided lung biopsy was performed in 440 patients. Two h...
journal_title:European journal of radiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejrad.2012.09.013
更新日期:2013-01-01 00:00:00
abstract::Contrast-enhanced sonography is a widely available imaging modality for the diagnosis of pancreatic diseases. With this procedure, pancreatic tumours can be differentiated better. Furthermore, contrast-enhanced sonography produces good results in the staging of acute pancreatitis severity, especially in the detection ...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2007.06.035
更新日期:2007-11-01 00:00:00
abstract::Operative ultrasonography is very useful in carotid artery surgery--First to show before the reconstruction the site, the degree and the shape of the lesions--second after the reconstruction to appreciate its quality. In our 26 cases, reintervention was performed in five cases but only 3 have had a second reconstructi...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract:PURPOSE:Objective quantification of brain structure can aid diagnosis and therapeutic monitoring in several neuropsychiatric disorders. In this study, we aimed to compare direct and indirect quantification approaches for hippocampal formation changes in patients with mild cognitive impairment and Alzheimer's disease (A...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2007.06.009
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The purpose of our study was to determine the breast radiation dose during coronary calcium scoring with multidetector computerized tomography (MDCT). We also evaluated the degree of dose reduction by using a bismuth breast shield when performing coronary calcium scoring with MDCT. MATERIALS AND METHODS:The ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2006.08.012
更新日期:2007-01-01 00:00:00
abstract::Two principally different 1000-line CRT (cathode ray tube) monitors connected to a digital image intensifier system for chest radiography were compared in terms of image quality and viewing comfort. Image quality was assessed by means of ROC analysis. Five observers tried to find simulated pathology positioned over th...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(96)00750-4
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:To investigate the diagnostic value of retrospective fusion of pelvic MRI and (18)F-fluorodeoxyglucose ((18)F-FDG) PET images for assessment of locoregional extension and nodal staging of endometrial cancer. MATERIALS AND METHODS:Thirty patients with biopsy-proven endometrial cancer underwent preoperative cont...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2013.05.005
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:To assess the dose-normalized iodine contrast-to-noise-ratio (CNRD) improvement and contrast media reduction potential obtained with photon-counting (PC) CT compared to conventional energy-integrating (EI) CT as a function of patient size and tube voltage. METHOD:Images of a semi-anthropomorphic phantom of dif...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.108909
更新日期:2020-05-01 00:00:00
abstract::Posterior ankle impingement is a clinical diagnosis which can be seen following a traumatic hyper-plantar flexion event and may lead to painful symptoms in athletes such as female dancers ('en pointe'), football players, javelin throwers and gymnasts. Symptoms of posterior ankle impingement are due to failure to accom...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2015.07.017
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate reproducibility of a fast MRI protocol to measure gastric emptying and motility of the gastric antrum. METHODS AND MATERIALS:Gastric emptying and antral speed were measured in 12 type 1 diabetic patients (mean age 43 years) and 9 healthy volunteers (mean age 31 years). Sub...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.04.071
更新日期:2010-08-01 00:00:00