Abstract:
:The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of sequence similarity. TRP channels are nonselective monovalent cation channels, most of which also allow passage of Ca(2+). Many members of each of these families, but not all, are involved in sensory signal transduction. The C-type (for canonical or classical) subfamily, differs from the other TRP subfamilies in that it fulfills two different types of function: membrane depolarization, resembling sensory transduction TRPs, and mediation of sustained increases in intracellular Ca(2+). The mechanism(s) by which the C-class of TRP channels-the TRPCs-are activated is poorly understood and their role in mediating intracellular Ca(2+) increases is being questioned. Both of these questions-mechanism of activation and participation in Ca(2+) entry-are the topics of this review.
journal_name
Annu Rev Pharmacol Toxicoljournal_title
Annual review of pharmacology and toxicologyauthors
Birnbaumer Ldoi
10.1146/annurev.pharmtox.48.113006.094928subject
Has Abstractpub_date
2009-01-01 00:00:00pages
395-426eissn
0362-1642issn
1545-4304journal_volume
49pub_type
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journal_title:Annual review of pharmacology and toxicology
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