Abstract:
UNLABELLED:Furosemide test is a simple and useful test of renal physiology used to evaluate the capability of the collecting ducts to secrete potassium under the effect of serum aldosterone. Its behaviour pattern has been established in children and young adults but not described in very old healthy people, which we explored in this study. MATERIAL AND METHODS:Twenty-six healthy volunteers on a standard Western diet (50 mmol of K/day) were studied: 20 of them were young (between 17 and 40 years old) and the rest were very old (between 75 and 85 years old). They suffered from no diseases and were not on any medication. Before, during the test and 180 min after a single dose of intravenous furosemide (1 mg/kg), urine and blood samples were obtained for creatinine and electrolytes levels. From these data we calculated fractional excretion (FE) of electrolytes; serum aldosterone was measured pre and post furosemide infusion. Statistical analysis was performed by applying Student's t-test. RESULTS:There was no significant difference regarding pre-furosemide (basal) FE of potassium between the very old and young group. Post-furosemide average FE of potassium was significantly lower in the very old group (27.4 +/- 2%) compared with the young group (35.4 +/- 9%) (P = 0.04). Even though there was no significant difference in post-furosemide peak FE of potassium value, it was reached later in the very old (120 min) compared with the young (30 min). Serum aldosterone levels were significantly higher post furosemide in both groups: 18.3 +/- 12.2 ng/dl (pre) versus 32.5 +/- 18.6 ng/dl (post) in the young (P = 0.007) and 69.8 +/- 13.7 ng/dl (pre) versus 113.3 +/- 54.8 ng/dl (post) in the very old (P = 0.04). Furthermore, all serum aldosterone values (pre and post furosemide) were significantly higher in very old people compared with young people (P < 0.001). Basal fractional excretion of sodium and chloride were slightly higher in the very old group compared with the young group (P = 0.05). Average post-furosemide FE of sodium and chloride were slightly and significantly lower in the very old (P = 0.05 and P = 0.03), respectively. However, there was no significant difference in peak post-furosemide FE of sodium and chloride values, which were reached later in the very old (120 min) compared with the young (30 min). CONCLUSION:Furosemide test showed a significantly lower average post-furosemide FE of potassium value, delayed post-furosemide peak FE of Na, K and Cl and a hormonal pattern of aldosterone resistance in very old people.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Musso CG,Reynaldi J,Vilas M,De Miguel R,Imperiali N,Algranati Ldoi
10.1007/s11255-009-9547-8subject
Has Abstractpub_date
2010-03-01 00:00:00pages
273-7issue
1eissn
0301-1623issn
1573-2584journal_volume
42pub_type
杂志文章abstract:BACKGROUND:Undescended testis is a common problem, which is prevalent in 3 % of male infants. This study aimed to determine the effect of leaving the deep inguinal ring (DIR) without closure during laparoscopic orchiopexy (LO), with regard to post-operative hernia formation and other outcomes. METHODS:From 2012 to 201...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1438-1
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:To find the most beneficial method, we assessed patient comfort and morbidity rates during prostate biopsy procedures performed using periprostatic nerve blockade, unilateral pudendal nerve blockade, intrarectal lidocaine gel, and a combination of periprostatic nerve blockade and intrarectal lidocaine gel....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9237-3
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP). METHODS:A total of 172 CNBP patients and 151 healthy males were recruite...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0743-9
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Hypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of L-tryptophan depletion on survival and autophagy in cultures of renal proximal tubular epithelial cells (RPTECs) under hypoxia was evaluated. M...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1596-9
更新日期:2017-07-01 00:00:00
abstract::The aim of this study was to find out whether an improvement of vitamin D metabolism and its metabolites and a decrease of parathormones can be reached through a diet and UV irradiation. Forty-eight children with kidney insufficiency were divided into four groups: Group 1--diet according to Bergström with EAA and ceto...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::We report 3 cases of benign retroperitoneal schwannoma, of whom one presented with flank pain with hematuria, one presented with headache and secondary hypertension and one presented with recurrent renal colicky pain. Two patients were treated by open surgical excision of the tumor with nephrectomy of the correspondin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-4705-5
更新日期:2005-01-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9333-z
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Primary bladder neck obstruction (PBNO) is a nonneurogenic voiding disorder and frequently overlooked in young men. Prior studies have reported the efficacy of α-blockers only in the short-term for male patients with PBNO. We hereby report our long-term results using α1-blocker therapy in young men with PBNO....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0096-6
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Supracostal superior calyceal access has been shown to be the most suitable approach for staghorn calculi, calculi in the upper ureter, and complex inferior calyceal calculi. It is a good choice for direct access for most of the intrarenal collecting system and upper ureter. The aim of this retrospective stud...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9916-y
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:In this research, the normal anatomy of urethral sphincter complex in young Chinese males has been studied. METHODS:The sagittal, coronal, and axial T2-weighted non-fat suppressed fast spin-echo images of pelvic cavities of 86 Chinese young males were studied. RESULT:Urethral sphincter complex is a cylindrica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0686-1
更新日期:2014-08-01 00:00:00
abstract::Renal arterial embolization and subsequent nephrectomy or nephrectomy alone were performed in 34 patients with renal cell carcinoma. Renal arterial embolization caused a blood pressure elevation concomitant with an increase in plasma renin activity (PRA), urinary aldosterone excretion or urinary prostaglandin (PGE2) e...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549489
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:Control of hydration status is an important constituent of adequate and efficient hemodialysis (HD) treatment. Nevertheless, there are no precise clinical indices for early recognition of small changes in fluid status of patients undergoing chronic hemodialysis therapy. This study aimed to evaluate and compare ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1473-y
更新日期:2017-03-01 00:00:00
abstract::Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explain the development o...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1803-3
更新日期:2018-06-01 00:00:00
abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082706
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:Early detection of prostate cancer has become a matter of vital importance in modern societies. Ultrasound guided transrectal biopsy is the current standard urological procedure to detect prostate cancer. In this study our intention was to confirm the high tolerance and low complication rate of this procedure...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007168823851
更新日期:1999-01-01 00:00:00
abstract::Considering the aging dialysis population of today, increasing our knowledge about the nature, diagnosis and the treatment of bone mineral density (BMD) problems in end-stage renal disease (ESRD) patients deserves more attention. Osteoporosis is basicly defined as a decrease in bone mass. Large epidemiological studies...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-006-9109-2
更新日期:2007-01-01 00:00:00
abstract::A low body mass index (BMI) and serum albumin are associated with increased risk of mortality in patients with chronic kidney disease (CKD). The purpose of this study was to evaluate BMI and serum albumin as predictors of all-cause and cardiovascular (CV) mortality in hemodialysed (HD) patients. We describe the result...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9201-2
更新日期:2007-01-01 00:00:00
abstract::A prospective study of plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) in 51 men before vasectomy and 10 days and 3 months after vasectomy revealed a trend to rise in LH 10 days after vasectomy normalizing after 3 months. The literature concerning alterations in LH and FSH after vasectomy is rev...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549744
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to determine the morbidity of lumbotomy incision used in the last 100 living related donor nephrectomies retrospectively. METHODS:Since March 1991, 100 donor nephrectomies were made to living donors with lumbar incision. Incisions made in lateral decubitus position, subcostally o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1015000328796
更新日期:2001-01-01 00:00:00
abstract::The white blood cell count (WBC) decreases during haemodialysis and it was investigated as a function of different dialysis membranes. Each of them was used four times, applying different sterilization methods. Twelve chronic haemodialysis patients were studied and dialysed with cuprophan and polyacrylonitrile (PAN) m...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082704
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abstract::This study presents a view of the knowledge the authors have gathered during 11 years of work with radioisotope examinations of the kidneys and ureteral urine passage performed in 34 children. As an important indication field they consider the conditions where excretory urography or separate functional examination, re...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02217144
更新日期:1980-01-01 00:00:00
abstract::This paper presents a newly developed simple procedure using overlapping vascularized dorsal dartos subcutaneous flaps to cover the neourethra after hypospadias correction. A 3-year old boy with distal hypospadias underwent the tubularized incised plate urethroplasty using this method. Postoperative complications, whi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025610800998
更新日期:2002-01-01 00:00:00
abstract::We report a case of 20-year-old farmer with penile amputation and emasculation secondary to crushing injury inflicted by agricultural machinery. His entire penis, scrotum and both the testis had been avulsed after falling onto a rotating axel wheel of an electronically driven thrashing machine. After resuscitation the...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0918-x
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To suggest a different method for diagnosing vesicoureteral reflux (VUR) in lieu of voiding cystourethrography (VCU), in order to prevent radiation exposure. MATERIALS AND METHODS:Fifty-two ureterorenal units of 26 patients were evaluated ultrasonographically for visualizing the renal collecting systems, both ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550307
更新日期:1998-01-01 00:00:00
abstract:AIMS:This case report describes juxtaglomerular cell tumor-a rare renin-producing tumor of the kidney, complicating pregnancy. CLINICAL CASE:A previously healthy 24-year-old primigravid woman developed hypertension in the 20th week of pregnancy, leading to a miscarriage in the 28th week. However, hypertension continue...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9782-z
更新日期:2011-06-01 00:00:00
abstract::Five cases of spontaneous rupture of the renal parenchyma are reported. Two patients had renal cell cancer, one sustained acute purulent pyelonephritis secondary to stone related ureteral obstruction, one suffered from aposthematous pyelonephritis without obstruction, while one had chronic pyelonephritis and a cortica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768275
更新日期:1994-01-01 00:00:00
abstract::Five characteristics of neonate renal physiology, namely glomerular hypofiltration, low renal blood flow and alterations in water, sodium and potassium management, disappear during the first year of life but reoccur during senescence. However, the underlying mechanisms are different during the two periods. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034681.60457.84
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To examine whether platelet-to-lymphocyte ratio (PLR) is associated with 5-year mortality in patients with chronic kidney disease (CKD), we performed this study using data from the National Health and Nutrition Examination Survey (NHANES) through 1999 to 2006. METHODS:3285 patients with CKD stage 1-5 were incl...
journal_title:International urology and nephrology
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abstract:PURPOSE:Bone metabolism disorder is often associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Sclerostin, a novel candidate protein, has been identified to be involved in the bone-vascular axis. The aims of the current investigation were to assess vessel sclerostin expression and...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1604-0
更新日期:2017-08-01 00:00:00
abstract::The vaginal influx during miction is a frequent phenomenon. In our clinical study it showed a rate of 54 per cent. The significance of pathomorphological substrates is diminishing with the advancing vesical descensus. The posture during miction has but little influence on the vaginal deviation of the urinary stream. T...
journal_title:International urology and nephrology
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